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Generative Adversarial Learning of Protein Tertiary Structures [PDF]
Molecules, 2021 Protein molecules are inherently dynamic and modulate their interactions with different molecular partners by accessing different tertiary structures under physiological conditions. Elucidating such structures remains challenging.
Taseef Rahman +3 more
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Biomolecules, 2022 With the debut of AlphaFold2, we now can get a highly-accurate view of a reasonable equilibrium tertiary structure of a protein molecule. Yet, a single-structure view is insufficient and does not account for the high structural plasticity of protein ...
Fardina Fathmiul Alam, Amarda Shehu
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Protein Macrocyclization for Tertiary Structure Stabilization [PDF]
ChemBioChem, 2021 AbstractProteins possess unique molecular recognition capabilities and enzymatic activities, features that are usually tied to a particular tertiary structure. To make use of proteins for biotechnological and biomedical purposes, it is often required to enforce their tertiary structure in order to ensure sufficient stability under the conditions ...
Anissa Haim +2 more
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Reducing Ensembles of Protein Tertiary Structures Generated De Novo via Clustering
Molecules, 2020 Controlling the quality of tertiary structures computed for a protein molecule remains a central challenge in de-novo protein structure prediction. The rule of thumb is to generate as many structures as can be afforded, effectively acknowledging that ...
Ahmed Bin Zaman +3 more
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Advances in protein tertiary structure prediction
Biomedical and Biotechnology Research Journal, 2018 Proteins are composed of linear chains of amino acids that form a unique three-dimensional structure in their native environment. Such native structure favors the proteins to perform their biochemical activity.
Tayebeh Farhadi
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Recent Progress of Protein Tertiary Structure Prediction
MoleculesThe prediction of three-dimensional (3D) protein structure from amino acid sequences has stood as a significant challenge in computational and structural bioinformatics for decades.
Qiqige Wuyun +7 more
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Modeling the Tertiary Structure of the Rift Valley Fever Virus L Protein
Molecules, 2019 A tertiary structure governs, to a great extent, the biological activity of a protein in the living cell and is consequently a central focus of numerous studies aiming to shed light on cellular processes central to human health. Here, we aim to elucidate
Gideon K. Gogovi +5 more
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Tertiary alphabet for the observable protein structural universe [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Proteins fold into intricate 3D structures, determined by their amino acid sequences. Different proteins can fold into drastically different structures, and the space of all possible structures appears hopelessly complex.
Gevorg Grigoryan
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Coupled prediction of protein secondary and tertiary structure [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2003 The strong coupling between secondary and tertiary structure formation in protein folding is neglected in most structure prediction methods. In this work we investigate the extent to which nonlocal interactions in predicted tertiary structures can be used to improve secondary structure prediction.
Jens Meiler, David Baker
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Molecular and in silico analysis of the coat protein of hibiscus chlorotic ringspot virus isolates [PDF]
Journal of Crop Protection, 2023 Hibiscus chlorotic ringspot virus (HCRSV), genus Betacarmovirus, family Tombusviridae, is a common pathogen of hibiscus plants in tropical and subtropical regions. During 2020-2021, leaf samples of Chinese hibiscus Hibiscus rosa-sinensis L. with mottling
Nadia Mosharaf +4 more
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