Results 11 to 20 of about 180,875 (351)
Generative Adversarial Learning of Protein Tertiary Structures [PDF]
Molecules, 2021 Protein molecules are inherently dynamic and modulate their interactions with different molecular partners by accessing different tertiary structures under physiological conditions. Elucidating such structures remains challenging.
Taseef Rahman +3 more
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Protein Macrocyclization for Tertiary Structure Stabilization [PDF]
ChemBioChem, 2021 AbstractProteins possess unique molecular recognition capabilities and enzymatic activities, features that are usually tied to a particular tertiary structure. To make use of proteins for biotechnological and biomedical purposes, it is often required to enforce their tertiary structure in order to ensure sufficient stability under the conditions ...
Anissa Haim +2 more
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Tertiary alphabet for the observable protein structural universe [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Proteins fold into intricate 3D structures, determined by their amino acid sequences. Different proteins can fold into drastically different structures, and the space of all possible structures appears hopelessly complex.
Gevorg Grigoryan
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PROTINFO: secondary and tertiary protein structure prediction [PDF]
Nucleic Acids Research, 2003 Information about the secondary and tertiary structure of a protein sequence can greatly assist biologists in the generation and testing of hypotheses, as well as design of experiments. The PROTINFO server enables users to submit a protein sequence and request a prediction of the three-dimensional (tertiary) structure based on comparative modeling ...
Ling-Hong Hung, Ram Samudrala
semanticscholar +4 more sources
Biomolecules, 2022 With the debut of AlphaFold2, we now can get a highly-accurate view of a reasonable equilibrium tertiary structure of a protein molecule. Yet, a single-structure view is insufficient and does not account for the high structural plasticity of protein ...
Fardina Fathmiul Alam, Amarda Shehu
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Reducing Ensembles of Protein Tertiary Structures Generated De Novo via Clustering
Molecules, 2020 Controlling the quality of tertiary structures computed for a protein molecule remains a central challenge in de-novo protein structure prediction. The rule of thumb is to generate as many structures as can be afforded, effectively acknowledging that ...
Ahmed Bin Zaman +3 more
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Protein Tertiary Structure by Crosslinking/Mass Spectrometry [PDF]
Trends in Biochemical Sciences, 2018 Observing the structures of proteins within the cell and tracking structural changes under different cellular conditions are the ultimate challenges for structural biology. This, however, requires an experimental technique that can generate sufficient data for structure determination and is applicable in the native environment of proteins. Crosslinking/
Michael Schneider +2 more
openaire +4 more sources
Advances in protein tertiary structure prediction
Biomedical and Biotechnology Research Journal, 2018 Proteins are composed of linear chains of amino acids that form a unique three-dimensional structure in their native environment. Such native structure favors the proteins to perform their biochemical activity.
Tayebeh Farhadi
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Modeling the Tertiary Structure of the Rift Valley Fever Virus L Protein
Molecules, 2019 A tertiary structure governs, to a great extent, the biological activity of a protein in the living cell and is consequently a central focus of numerous studies aiming to shed light on cellular processes central to human health. Here, we aim to elucidate
Gideon K. Gogovi +5 more
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Protein–Protein Interactions Mediated by Helical Tertiary Structure Motifs
Journal of the American Chemical Society, 2015 The modulation of protein–protein interactions (PPIs) by means of creating or stabilizing secondary structure conformations is a rapidly growing area of research.
A. Watkins, Michael G. Wuo, P. Arora
semanticscholar +2 more sources