Results 21 to 30 of about 6,710,080 (339)
Cells, 2023 Long, noncoding RNAs (lncRNAs) are indispensable for normal cell physiology and, consequently, are tightly regulated in human cells. Yet, unlike mRNA, substantially less is known about the mechanisms for lncRNA degradation.
Maram Quttina +8 more
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Journal for ImmunoTherapy of Cancer, 2021 Background Although oncolytic virotherapy has shown substantial promises as a new treatment modality for many malignancies, further improvement on its therapeutic efficacy will likely bring more clinical benefits.
Guangsheng Pei +5 more
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Cell Communication and Signaling, 2020 Background Hormone receptor positive (HR+) breast cancer (BCa) is the most frequently diagnosed subtype. Acquired and intrinsic resistance to conventional endocrine therapy (ET) commonly occurs and prompts incurable metastatic disease.
Shaymaa Bahnassy +8 more
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Signaling by Nuclear Receptors [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Nuclear receptors are activated by lipid-soluble signals (e.g., steroid hormones) that cross the plasma membrane. Once activated, most function as transcription factors to control gene expression for numerous biological processes.
Richard, Sever, Christopher K, Glass
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Molecular Therapy: Oncolytics, 2021 The oncolytic effect of virotherapy derives from the intrinsic capability of the applied virus in selectively infecting and killing tumor cells. Although oncolytic viruses of various constructions have been shown to efficiently infect and kill tumor ...
Divya Ravirala +3 more
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Nuclear receptors in osteoclasts
Current Opinion in Pharmacology, 2020 Osteoclasts are bone-resorbing cells that play an essential role in the remodeling of bone under physiological conditions and numerous pathological conditions, such as osteoporosis, bone metastasis, and inflammatory bone erosion. Nuclear receptors are crucial to various physiological processes, including metabolism, development and inflammation, and ...
Seyeon, Bae +2 more
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The nuclear receptor superfamily [PDF]
Journal of Cell Science, 2003 Nuclear receptors are one of the most abundant classes of transcriptional regulators in animals (metazoans). They regulate diverse functions, such as homeostasis, reproduction, development and metabolism (for a review, see [Laudet and Gronemeyer, 2002][1]).
Robinson-Rechavi, M. +2 more
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Non-transport roles of nuclear import receptors: In need of the right balance
Frontiers in Cell and Developmental Biology, 2022 Nuclear import receptors ensure the recognition and transport of proteins across the nuclear envelope into the nucleus. In addition, as diverse processes as mitosis, post-translational modifications at mitotic exit, ciliogenesis, and phase separation ...
Michela Damizia +4 more
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Hybrid reporter gene assays: Versatile in vitro tools to characterize nuclear receptor modulators
, 2022 S.175-192Nuclear receptors act as ligand-activated transcription factors translating ligand signals into changes in gene expression. The 48 members of the superfamily of nuclear receptors identified so far are involved amongst others in maintenance of ...
Heering, J., Merk, D.
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Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis
Breast Cancer Research, 2017 Background Upregulation of estrogen receptor beta (ERβ) in breast cancer cells is associated with epithelial maintenance, decreased proliferation and invasion, and a reduction in the expression of the receptor has been observed in invasive breast tumors.
Igor Bado +8 more
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