Results 21 to 30 of about 855,861 (301)

Liver X Receptor Regulation of Glial Cell Functions in the CNS

Biomedicines, 2022
In this review, we discuss the role of liver X receptors (LXRs) in glial cells (microglia, oligodendrocytes and astrocytes) in the central nervous system (CNS).
Xiaoyu Song, Wanfu Wu, Margaret Warner, Jan-Åke Gustafsson   +3 more
doaj   +1 more source

NUCLEAR RECEPTORS [PDF]

British Journal of Pharmacology, 2007
ALEXANDER, S.P.H., MATHIE, A. & PETERS, J.A. (2007). Guide to Receptors and Channels (GRAC), 2nd edition (2007 revision). Br. J. Pharmacol., 150 (Suppl. 1), S1–S168.
S. P. H. Alexander, A Mathie, J. A. Peters   +2 more
openaire   +3 more sources

Exosc9 Initiates SUMO-Dependent lncRNA TERRA Degradation to Impact Telomeric Integrity in Endocrine Therapy Insensitive Hormone Receptor-Positive Breast Cancer

Cells, 2023
Long, noncoding RNAs (lncRNAs) are indispensable for normal cell physiology and, consequently, are tightly regulated in human cells. Yet, unlike mRNA, substantially less is known about the mechanisms for lncRNA degradation.
Maram Quttina, Kacie D. Waiters, Ashfia Fatima Khan, Samaneh Karami, Anthony S. Peidl, Mariam Funmi Babajide, Justus Pennington, Fatima A. Merchant, Tasneem Bawa-Khalfe   +8 more
doaj   +1 more source

Co-delivery of novel bispecific and trispecific engagers by an amplicon vector augments the therapeutic effect of an HSV-based oncolytic virotherapy

Journal for ImmunoTherapy of Cancer, 2021
Background Although oncolytic virotherapy has shown substantial promises as a new treatment modality for many malignancies, further improvement on its therapeutic efficacy will likely bring more clinical benefits.
Guangsheng Pei, Zhongming Zhao, Divya Ravirala, Brandon Mistretta, Preethi H Gunaratne, Xiaoliu Zhang   +5 more
doaj   +1 more source

The nuclear receptor superfamily [PDF]

Journal of Cell Science, 2003
Nuclear receptors are one of the most abundant classes of transcriptional regulators in animals (metazoans). They regulate diverse functions, such as homeostasis, reproduction, development and metabolism (for a review, see [Laudet and Gronemeyer, 2002][1]).
Robinson-Rechavi, M., Escriva-Garcia, H., Laudet, V.   +2 more
openaire   +3 more sources

Constitutively active androgen receptor supports the metastatic phenotype of endocrine-resistant hormone receptor-positive breast cancer

Cell Communication and Signaling, 2020
Background Hormone receptor positive (HR+) breast cancer (BCa) is the most frequently diagnosed subtype. Acquired and intrinsic resistance to conventional endocrine therapy (ET) commonly occurs and prompts incurable metastatic disease.
Shaymaa Bahnassy, Hariprasad Thangavel, Maram Quttina, Ashfia Fatima Khan, Dhanya Dhanyalayam, Joan Ritho, Samaneh Karami, Jing Ren, Tasneem Bawa-Khalfe   +8 more
doaj   +1 more source

Single-cell RNA sequencing reveals a strong connection between Gadd45g upregulation and oncolytic HSV infection in tumor tissue

Molecular Therapy: Oncolytics, 2021
The oncolytic effect of virotherapy derives from the intrinsic capability of the applied virus in selectively infecting and killing tumor cells. Although oncolytic viruses of various constructions have been shown to efficiently infect and kill tumor ...
Divya Ravirala, Guangsheng Pei, Zhongming Zhao, Xiaoliu Zhang   +3 more
doaj   +1 more source

Signaling by Nuclear Receptors [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Nuclear receptors are activated by lipid-soluble signals (e.g., steroid hormones) that cross the plasma membrane. Once activated, most function as transcription factors to control gene expression for numerous biological processes.
Richard, Sever, Christopher K, Glass
openaire   +2 more sources

Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis

Breast Cancer Research, 2017
Background Upregulation of estrogen receptor beta (ERβ) in breast cancer cells is associated with epithelial maintenance, decreased proliferation and invasion, and a reduction in the expression of the receptor has been observed in invasive breast tumors.
Igor Bado, Fotis Nikolos, Gayani Rajapaksa, Wanfu Wu, Jessica Castaneda, Savitri Krishnamurthy, Paul Webb, Jan-Åke Gustafsson, Christoforos Thomas   +8 more
doaj   +1 more source

Non-transport roles of nuclear import receptors: In need of the right balance

Frontiers in Cell and Developmental Biology, 2022
Nuclear import receptors ensure the recognition and transport of proteins across the nuclear envelope into the nucleus. In addition, as diverse processes as mitosis, post-translational modifications at mitotic exit, ciliogenesis, and phase separation ...
Michela Damizia, Ludovica Altieri, Ludovica Altieri, Patrizia Lavia, Patrizia Lavia   +4 more
doaj   +1 more source