Results 21 to 30 of about 548,108 (301)

Non-transport roles of nuclear import receptors: In need of the right balance

Frontiers in Cell and Developmental Biology, 2022
Nuclear import receptors ensure the recognition and transport of proteins across the nuclear envelope into the nucleus. In addition, as diverse processes as mitosis, post-translational modifications at mitotic exit, ciliogenesis, and phase separation ...
Michela Damizia, Ludovica Altieri, Ludovica Altieri, Patrizia Lavia, Patrizia Lavia   +4 more
doaj   +1 more source

Nuclear receptors in osteoclasts

Current Opinion in Pharmacology, 2020
Osteoclasts are bone-resorbing cells that play an essential role in the remodeling of bone under physiological conditions and numerous pathological conditions, such as osteoporosis, bone metastasis, and inflammatory bone erosion. Nuclear receptors are crucial to various physiological processes, including metabolism, development and inflammation, and ...
Seyeon, Bae, Steven, Zeng, Kyung-Hyun, Park-Min   +2 more
openaire   +3 more sources

Hybrid reporter gene assays: Versatile in vitro tools to characterize nuclear receptor modulators

, 2022
S.175-192Nuclear receptors act as ligand-activated transcription factors translating ligand signals into changes in gene expression. The 48 members of the superfamily of nuclear receptors identified so far are involved amongst others in maintenance of ...
Heering, J., Merk, D.
core   +1 more source

Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis

Breast Cancer Research, 2017
Background Upregulation of estrogen receptor beta (ERβ) in breast cancer cells is associated with epithelial maintenance, decreased proliferation and invasion, and a reduction in the expression of the receptor has been observed in invasive breast tumors.
Igor Bado, Fotis Nikolos, Gayani Rajapaksa, Wanfu Wu, Jessica Castaneda, Savitri Krishnamurthy, Paul Webb, Jan-Åke Gustafsson, Christoforos Thomas   +8 more
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Nuclear Receptors as Regulators of Pituitary Corticotroph Pro-Opiomelanocortin Transcription [PDF]

, 2020
The hypothalamic–pituitary–adrenal (HPA) axis plays a critical role in adaptive stress responses and maintaining organism homeostasis. The pituitary corticotroph is the central player in the HPA axis and is regulated by a plethora of hormonal
Anthony P. Heaney, Zhang, Dongyun, Heaney, Anthony P, Dongyun Zhang   +3 more
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The role of pregnane X receptor (PXR) in substance metabolism

Frontiers in Endocrinology, 2022
As a member of the nuclear receptor (NR) superfamily, pregnane X receptor (PXR; NR1I2) is a ligand-activated transcription factor that plays a crucial role in the metabolism of xenobiotics and endobiotics in mammals.
Ye Lv, Yi-Yang Luo, Hui-Wen Ren, Hui-Wen Ren, Cheng-Jie Li, Zhi-Xin Xiang, Zhi-Lin Luan, Zhi-Lin Luan   +7 more
doaj   +1 more source

The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals [PDF]

, 2004
BACKGROUND: Drugs and other xenobiotics alter gene expression of cytochromes P450 (CYP) by activating the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in mammals.
Urs A Meyer, Handschin, C., Gnerre, C, Sharon Blättler, Meyer, U A, Blattler, S., Handschin, C, Podvinec, M, Oscarson, M., Michael Podvinec, Michel R Kaufmann, Adrian Roth, Kaufmann, M R, Looser, R, Carmela Gnerre, Roth, A., Roth, A, Meyer, U. A., Gnerre, C., Blättler, S, Christoph Handschin, Kaufmann, M. R., Renate Looser, Looser, R., Mikael Oscarson, Oscarson, M, Podvinec, M.   +26 more
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Dynamics of Nuclear Receptors [PDF]

Structure, 2010
The dynamic properties of VDR LBD and full-length VDR/RXRα heterodimer in the presence and absence of ligands were investigated by hydrogen/deuterium exchange mass spectrometry (Zhang et al., 2010a). The results beautifully complement X-ray crystal structure data.
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The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis [PDF]

Human Reproduction Update, 2014
Endometriosis is defined as the colonization and growth of endometrial tissue at anatomic sites outside the uterine cavity. Up to 15% of reproductive-aged women in the USA suffer from painful symptoms of endometriosis, such as infertility, pelvic pain, menstrual cycle abnormalities and increased risk of certain cancers.
Sang Jun, Han, Bert W, O'Malley
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Full-length nuclear receptor allosteric regulation

Journal of Lipid Research, 2023
Nuclear receptors are a superfamily of transcription factors regulated by a wide range of lipids that include phospholipids, fatty acids, heme-based metabolites, and cholesterol-based steroids. Encoded as classic two-domain modular transcription factors,
Woong Jae Choi, Zeinab Haratipour, Raymond D. Blind   +2 more
doaj   +1 more source