Results 81 to 90 of about 24,047 (218)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source

Transcriptional Control of Trpm6 by the Nuclear Receptor FXR

, 2022
Farnesoid x receptor (FXR) is a nuclear bile acid receptor that belongs to the nuclear receptor superfamily. It plays an essential role in bile acid biosynthesis, lipid and glucose metabolism, liver regeneration, and vertical sleeve gastrectomy.
Jae Man Lee, Eun Young Kim
core   +1 more source

Tailoring obeticholic acid activity by iridium(III) complex conjugation to develop a farnesoid X receptor probe

Journal of Advanced Research
Introduction: The farnesoid X receptor (FXR) is a crucial regulator in the intestine, maintaining bile acid homeostasis. Inhibiting intestinal FXR shows promise in managing inflammatory bowel and liver diseases by reducing bile acid accumulation ...
Dou Niu, Xiaolei Wu, Yuxin Zhang, Xueliang Wang, Daniel Shiu-Hin Chan, Shaozhen Jing, Chun-Yuen Wong, Wanhe Wang, Chung-Hang Leung   +8 more
doaj   +1 more source

Impact of bile acids on the growth of human cholangiocarcinoma via FXR

Journal of Hematology & Oncology, 2011
Background The objective of the study was to investigate the effect of different types of bile acids on proliferation of cholangiocarcinoma and the potential molecular mechanisms. Methods PCR assay and Western blot were performed to detect the expression
Zhang Yinxin, Dong Ying, Shi Yihui, Wang Hongxia, Dai Jiaqi, Wang Jian   +5 more
doaj   +1 more source

Normal cholestanol in a genetically confirmed cerebrotendious xanthomatosis case presenting as neonatal jaundice

JPGN Reports, EarlyView.
Abstract Cerebrotendinous xanthomatosis (CTX) is a treatable genetic disorder associated with deficiency of the sterol 27‐hydroxylase enzyme (CYP27A1), important in bile acid synthesis. CTX may present in the newborn period as hepatic jaundice/cholestasis, that can resolve or can progress to fatal liver disease.
Andrea E. DeBarber, Maya Fowler, P. Barton Duell, Eric Dybbro   +3 more
wiley   +1 more source

An intact FXR signalling is required to preserve TLR9 action.

, 2013
TNBS colitis was induced in FXR+/+ and FXR−/− mice. Mice were administered CpG as described in materials and methods. (A–C) Analysis of Disease activity index (DAI) in FXR+/+ (A) and FXR−/− mice (C).
Barbara Renga (134135), Angela Zampella (186821), Stefano Fiorucci (134151), Andrea Mencarelli (134128), Sabrina Cipriani (134132), Claudio D'Amore (134144), Angela Bruno (134140), Daniela Francisci (167519), Eleonora Distrutti (134147), Adriana Carino (277117)   +9 more
core   +1 more source

Discovery of 9,11-Seco-Cholesterol Derivatives as Novel FXR Antagonists

, 2022
The farnesoid X receptor (FXR) plays an important role in the regulation of bile acid, lipid, and glucose homeostasis. Recent findings have shown that the inhibition of FXR is beneficial to improvement of related metabolic diseases and cholestasis.
Cui-Na Li (12537420), Jia-Xu Zhou (12537417), Su-Qin Lin (12537426), Cen Xie (1456096), Ying Wang (11406), Ya-Meng Liu (12537423), Fa-Jun Nan (62994)   +6 more
core   +1 more source

Genome-wide binding and transcriptome analysis of human farnesoid X receptor in primary human hepatocytes.

PLoS ONE, 2014
Background & aimsFarnesoid X receptor (FXR, NR1H4) is a ligand-activated transcription factor, belonging to the nuclear receptor superfamily. FXR is highly expressed in the liver and is essential in regulating bile acid homeostasis.
Le Zhan, Hui-Xin Liu, Yaping Fang, Bo Kong, Yuqi He, Xiao-Bo Zhong, Jianwen Fang, Yu-Jui Yvonne Wan, Grace L Guo   +8 more
doaj   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source