Results 101 to 110 of about 40,710 (290)
SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis
Nature Communications, 2020 Farnesoid X receptor (FXR) is a promising target for nonalcoholic steatohepatitis (NASH) and fibrosis. Although various FXR agonists have shown anti-fibrotic effects in diverse preclinical animal models, the response rate and efficacies in clinical ...
Jiyu Zhou +11 more
semanticscholar +1 more source
Hepatology Communications, 2021 Farnesoid X receptor (FXR) is a nuclear receptor that controls gene regulation of different metabolic pathways and represents an upcoming drug target for various liver diseases.
Emilian Jungwirth +4 more
doaj +1 more source
Pair correlation densities of inhomogeneous quadratic forms [PDF]
, 2002 Under explicit diophantine conditions on $(\alpha,\beta)\in\RR^2$, we prove that the local two-point correlations of the sequence given by the values $(m-\alpha)^2+\break (n-\beta)^2$, with $(m,n)\in\ZZ^2$, are those of a Poisson process.
Marklof, Jens
core +5 more sources
Farnesoid X receptor represses hepatic lipase gene expression
Journal of Lipid Research, 2004 The farnesoid X receptor (FXR) is a nuclear receptor that regulates gene expression in response to bile acids (BAs). FXR plays a central role in BA, cholesterol, and lipoprotein metabolism.
Audrey Sirvent +7 more
doaj +1 more source
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis (NASH).
Journal of Medicinal Chemistry, 2020 Farnesoid X receptor (FXR) agonists are emerging as important potential therapeutics for the treatment of nonalcoholic steatohepatitis (NASH) patients as they exert positive effects on multiple aspects of the disease.
Chianelli Donatella +30 more
semanticscholar +1 more source
Simulations reveal unique roles for the FXR hinge in the FXR-RXR nuclear receptor heterodimer
ACS Bio & Med Chem AuNuclear receptors are multidomain transcription factors whose full-length quaternary architecture is poorly described and understood. Most nuclear receptors bind DNA as heterodimers or homodimers, which could encompass a variety of arrangements of the individual domains.
Tracy Yu +3 more
openaire +4 more sources
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
Journal of Lipid Research, 2007 Bile acid concentrations are controlled by a feedback regulatory pathway whereby activation of the farnesoid X receptor (FXR) represses transcription of both the CYP7A1 gene, encoding the rate-limiting enzyme in the classic bile acid synthesis pathway ...
Insook Kim +7 more
doaj +1 more source
The Brain-Gut-Microbiome Axis. [PDF]
, 2018 Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis. Gut microbes communicate to the central nervous system through at least 3 parallel and interacting channels involving nervous, endocrine, and ...
Kalani, Amir +3 more
core +2 more sources