Results 121 to 130 of about 24,047 (218)

Postelectroacupuncture Fecal Microbiota Transplantation (post‐EA FMT) Regulates Gastrointestinal Hormones in Functional Dyspepsia Rats Is Associated With Modulation of the Intestinal Microbiota‐Bile Acid Metabolic Pathway

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background Electroacupuncture (EA) reshapes intestinal flora; whether post‐EA fecal microbiota transplantation (post‐EA FMT) regulates gastrointestinal hormones via the gut microbiota–bile acid (BA) pathway remains unclear. Methods Sham EA (SEA) served as control. Gastrointestinal hormones/motility were assessed post‐EA.
Yong‐Li Han, Dong‐Fang Shang, Juli Tang, Dong‐Dong Yu, Liang‐Yu Zhang, Jing Zhou, Qing‐Bo Wang   +6 more
wiley   +1 more source

GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms

Obesity Reviews, EarlyView.
ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani, Tzu‐Wen L. Cross, Erica de Jong, Emily S. Glover, Ivan D. Mendoza, Mojisola Adisa, Keigo Tomoo, Xinyi Zhou, Richard D. Mattes   +8 more
wiley   +1 more source

Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice

, 2012
Liver tumor, especially hepatocellular carcinoma (HCC), is closely associated with chronic inflammation. We previously showed that farnesoid X receptor knockout (FXR−/−) mice displayed chronic inflammation and developed spontaneous liver tumors when they
Yu, Hua, Guiyu Lou, Carl Van Ness, Zhou, Hong, Chao He, Zhang, Yunfeng, He, Chao, Wu, Jun, Hong Zhou, Lou, Guiyu, Ness, Carl Van, Meng, Zhipeng, Jun Wu, Hua Yu, Zhipeng Meng, Huang, Wendong, Xu, Rongzhen, Wendong Huang, Rongzhen Xu, Gan, Yichao, Xiaoqiong Wang, Wang, Xiaoqiong, Yunfeng Zhang, Yichao Gan   +23 more
core   +1 more source

Farnesoid X receptor activation protects against renal fibrosis via modulation of β-catenin signaling

Molecular Metabolism
Objective: Activation of farnesoid X receptor (FXR), a bile acid nuclear receptor, may be implicated in the pathophysiology of diabetic nephropathy. We explored a possible role for FXR activation in preventing renal fibrosis in high fat diet (HFD)-fed ...
Dan-Qin Sun, Fuqiang Yuan, Meng-Zhu Fu, Meng-Yang Zhong, Shi-Liang Zhang, Yan Lu, Giovanni Targher, Christopher D. Byrne, Ming-Hua Zheng, Wei-Jie Yuan   +9 more
doaj   +1 more source

Effects of Weight Loss Interventions on Gut Microbiota‐Derived Metabolites Linked to Cardiometabolic Health: A Systematic Review and Meta‐Analysis

Obesity Reviews, EarlyView.
ABSTRACT Background Gut microbiota‐derived metabolites are emerging as potential mediators between obesity and cardiometabolic conditions. While weight loss interventions modify microbiota composition, their effects on systemic microbial metabolites remain unclear.
Fernando Q. Iorra, Leonardo André Swarowsky Loebens, Andrea Auler, Eduarda Caroline Tasso Nascimento, Beatriz D. Schaan, Patrícia Martins Bock   +5 more
wiley   +1 more source

Long‐Term Metabolic Outcomes Following Bariatric Surgery: A Systematic Review, Meta‐Analysis, and Meta‐Regression

Obesity Reviews, EarlyView.
ABSTRACT Bariatric surgery (BS) has short‐ and medium‐term benefits in improving metabolic syndrome (MetS) components, but its long‐term impact remains incompletely characterized. This systematic review and meta‐analysis aimed to quantify the long‐term effects of BS (≥ 5 years) on fasting blood glucose (FBG), HDL cholesterol, triglycerides (TG), waist ...
Bernardo Paz Barboza, Pietro Ferrara, Lisa Ye, Lorenzo Losa, Gianluca Perseghin, Giovanni Cesana, Paolo Berta, Lorenzo Giovanni Mantovani   +7 more
wiley   +1 more source

SAR studies on FXR modulators led to the discovery of the first combined FXR antagonistic/TGR5 agonistic compound

, 2016
Bile acids can serve as signaling molecules by activating the nuclear receptor FXR and the G-protein-coupled receptor TGR5 and both bile acid receptors are prominent experimental drug targets.
Kaiser, Astrid, Gabler, Matthias, Merk, Daniel, Lamers, Christina, Schubert-Zsilavecz, Manfred, Flesch, Daniel   +5 more
core   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

FXR and MASH: an avenue for tissue-specific regulation

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a spectrum of conditions characterized by lipid accumulation in the liver known as steatosis not caused by excessive alcohol consumption. Approximately 25% of the US population have been

core   +1 more source

Reply to correspondence 2 on “GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in MASH livers” [PDF]

Clinical and Molecular Hepatology
Nahee Hwang, Sungsoon Fang
doaj   +1 more source