Farnesoid X-Activated Receptor Induces Apolipoprotein C-II Transcription: a Molecular Mechanism Linking Plasma Triglyceride Levels to Bile Acids [PDF]
Molecular Endocrinology, 2001 The farnesoid X-activated receptor (FXR; NR1H4), a member of the nuclear hormone receptor superfamily, induces gene expression in response to several bile acids, including chenodeoxycholic acid. Here we used suppression subtractive hybridization to identify apolipoprotein C-II (apoC-II) as an FXR target gene. Retroviral expression of FXR in HepG2 cells
Christopher J Sinal +2 more
exaly +6 more sources
The Human Apolipoprotein AV Gene Is Regulated by Peroxisome Proliferator-activated Receptor-α and Contains a Novel Farnesoid X-activated Receptor Response Element [PDF]
Journal of Biological Chemistry, 2003 The newly identified apolipoprotein AV (apoAV) gene is a key player in determining plasma triglyceride concentrations. Because hypertriglyceridemia is a major independent risk factor in coronary artery disease, the understanding of the regulation of the expression of this gene is of considerable importance.
Xavier Prieur
exaly +5 more sources
Saffron offers hepatoprotection via up-regulation of hepatic farnesoid-X-activated receptors in a rat model of acetaminophen-induced hepatotoxicity [PDF]
Avicenna Journal of Phytomedicine, 2021 Objectives: The most important toxicity of acetaminophen is hepatotoxicity. Farnesoid X-activated receptors (FXR) are one of the nuclear receptor superfamily members which have a pivotal role in the bile acid regulation.
Vahid Jamshidi +8 more
doaj +3 more sources
Identification of the DNA Binding Specificity and Potential Target Genes for the Farnesoid X-activated Receptor [PDF]
Journal of Biological Chemistry, 2000 The farnesoid X-activated receptor (FXR; NR1H4) is a member of the nuclear hormone receptor superfamily and functions as a heterodimer with the 9-cis-retinoic acid receptor (RXR). In order to determine the optimal DNA binding sequence for the FXR/RXR heterodimer, we have utilized the selected and amplified binding sequence imprinting technique.
B A, Laffitte +5 more
openaire +3 more sources
α-Crystallin Is a Target Gene of the Farnesoid X-activated Receptor in Human Livers [PDF]
Journal of Biological Chemistry, 2005 Alpha-crystallins comprise 35% of soluble proteins in the ocular lens and possess chaperone-like functions. Furthermore, the alphaA subunit (alphaA-crystallin) of alpha crystallin is thought to be "lens-specific" as only very low levels of expression were detected in a few non-lenticular tissues. Here we report that human alphaA-crystallin is expressed
Florence Y, Lee +6 more
openaire +3 more sources
Frontiers in Physiology, 2023 Hypertension characterized by an elevated blood pressure is a cardiovascular disease that afflicts greater than one in every three adults worldwide.
John D. Imig
doaj +3 more sources
Lipidome remodeling in primary biliary cholangitis [PDF]
Lipids in Health and DiseasePrimary biliary cholangitis (PBC) is a chronic, cholestatic liver disease characterized by progressive destruction of intrahepatic bile ducts, impaired bile flow, and complex disturbances in bile acid and lipid metabolism.
Magdalena Rogalska +5 more
doaj +2 more sources
Farnesoid X receptor (FXR): Structures and ligands
Computational and Structural Biotechnology Journal, 2021 Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved in the metabolic process of bile acid synthesis, transport and ...
Longying Jiang +4 more
doaj +3 more sources
Role of farnesoid X receptor and bile acids in alcoholic liver disease
Acta Pharmaceutica Sinica B, 2015 Alcoholic liver disease (ALD) is one of the major causes of liver morbidity and mortality worldwide. Chronic alcohol consumption leads to development of liver pathogenesis encompassing steatosis, inflammation, fibrosis, cirrhosis, and in extreme cases ...
Sharon Manley, Wenxing Ding
doaj +3 more sources
DOT1L Epigenetically Regulates Autophagy and Mitochondria Fusion in Cell Lines of Renal Cancer
Technology in Cancer Research & Treatment, 2023 Objectives DOT1L, a histone methylase, is overexpression in renal cell cancer. However, the role and detailed molecular mechanism of DOT1L involved in renal cancer development remain unknown.
Yanguang Hou MD +5 more
doaj +1 more source