Results 31 to 40 of about 53,933 (241)

Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors

Journal of Lipid Research, 2002
Affymetrix microarray data and Northern blot assays demonstrated that phospholipid transfer protein (PL222222222216) was induced 6-fold when either murine or human macrophages were incubated in the presence of ligands for the liver X receptor (LXR) and ...
Puiying A. Mak, Heidi R. Kast-Woelbern, Andrew M. Anisfeld, Peter A. Edwards   +3 more
doaj   +1 more source

High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

npj Systems Biology and Applications, 2021
The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce.
Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy C. Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen S. Ferguson, Keith A. Houck, John F. Wambaugh   +12 more
doaj   +1 more source

Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes

Redox Biology, 2022
The side effects of cisplatin, a widely used chemotherapeutic agent, include nephrotoxicity. Previous studies have reported that cisplatin induces ferroptosis and lipid peroxide accumulation.
Dong-Hyun Kim, Hoon‐In Choi, J. Park, C. Kim, E. Bae, S. Ma, S. Kim   +6 more
semanticscholar   +1 more source

Regulation of bile acid receptor activity

Liver Research, 2018
Many receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well as membrane receptors Takeda G protein receptor 5 ...
Yu-Jui Yvonne Wan, Lili Sheng
doaj   +1 more source

Repurposing drugs to target nonalcoholic steatohepatitis [PDF]

, 2019
Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage.
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source

New mechanistic insights into hepatoprotective activity of milk thistle and chicory quantified extract: The role of hepatic Farnesoid-X activated receptors.

Avicenna journal of phytomedicine, 2020
Farnesoid-X-activated receptors (FXR) are key modulators of liver regeneration. Milk thistle and Chicory are known as potent protective remedies in several liver disorders. The objective of this work was to examine the role of FXR in the hepato-healing properties of milk thistle (MTE) and chicory extracts (CE) in a rat model of acetaminophen-induced ...
Khalili, Azadeh, Fallah, Parviz, Hashemi, Seyed Ali, Ahmadian-Attari, Mohammad Mahdi, Jamshidi, Vahid, Mazloom, Roham, Beikzadeh, Leila, Bayat, Gholamreza   +7 more
openaire   +3 more sources

A triple farnesoid X receptor and peroxisome proliferator-activated receptor α/δ activator reverses hepatic fibrosis in diet-induced NASH in mice

Communications Chemistry, 2020
Non-alcoholic steatohepatitis (NASH) - a hepatic manifestation of the metabolic syndrome - is a multifactorial disease with alarming global prevalence. It involves steatosis, inflammation and fibrosis in the liver, thus demanding multiple modes of action
Pascal Heitel, Giuseppe Faudone, M. Helmstädter, Jurema Schmidt, A. Kaiser, A. Tjaden, M. Schröder, S. Müller, S. Schierle, Julius Pollinger, D. Merk   +10 more
semanticscholar   +1 more source

Nuclear farnesoid X receptor attenuates acute kidney injury through fatty acid oxidation.

Kidney International, 2022
Acute kidney injury (AKI) is a life-threatening condition that is one of most common side effects of cisplatin therapy. Fatty acid oxidation (FAO) is the main source of energy production in kidney proximal tubular epithelial cells (PTECs), but inhibited ...
Sujuan Xu, P. Jia, Yi Fang, Jifu Jin, Zhaoxing Sun, Weiran Zhou, Jie Li, Yunlu Zhang, Xiao-yan Wang, T. Ren, Zhouping Zou, Xiaoqiang Ding   +11 more
semanticscholar   +1 more source

Nuclear receptors in vascular biology [PDF]

, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
core   +3 more sources

Farnesoid-X receptor as a therapeutic target for inflammatory bowel disease and colorectal cancer

Frontiers in Pharmacology, 2022
Farnesoid-X receptor (FXR), as a nuclear receptor activated by bile acids, is a vital molecule involved in bile acid metabolism. Due to its expression in immune cells, FXR has a significant effect on the function of immune cells and the release of ...
Mengjiao Zhou, Danfeng Wang, Xiang Li, Ying Cao, Chengxue Yi, Dickson Kofi Wiredu Ocansey, Yulin Zhou, Fei Mao   +7 more
semanticscholar   +1 more source