Results 21 to 30 of about 53,933 (241)
Activation of the Farnesoid X-Activated Receptor Provides Protection against Acetaminophen-Induced Hepatic Toxicity [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2010 The nuclear receptor, farnesoid X receptor (FXR, NR1H4), is known to regulate cholesterol, bile acid, lipoprotein, and glucose metabolism. In the current study, we provide evidence to support a role for FXR in hepatoprotection from acetaminophen (APAP)-induced toxicity.
Florence Ying Lee +7 more
openaire +1 more source
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]
, 2010 This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K. +3 more
core +7 more sources
Iranian journal of basic medical sciences, 2022 This study aimed to evaluate the relationship between Farnesoid-X-activated receptors (FXR) as nuclear regulators of the antioxidant defense system as well as cardiac mitochondrial carrier proteins of UCP2 and UCP3 in cardiac damage induced by cirrhosis.Twenty-two male Wistar rats (200-250 g) were randomly divided into 3 experimental groups, including ...
Bayat, Gholamreza +6 more
openaire +3 more sources
Transcriptional coordination of hepatic autophagy by nutrient-sensing nuclear receptor PPARα and FXR [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2016 Nuclear receptors are in general ligand-dependent transcription factors that control a variety of mammalian physiologies including development, differentiation, proliferation, and homeostasis.
Jae Man Lee
doaj +1 more source
Farnesoid X receptor: From Structure to Function and Its Pharmacology in Liver Fibrosis
Aging and Disease, 2023 The farnesoid X receptor (FXR), a ligand-activated transcription factor, plays a crucial role in regulating bile acid metabolism within the enterohepatic circulation.
Chuan Ding +12 more
semanticscholar +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2021 Nonalcoholic fatty liver disease comprises a wide spectrum of liver injuries from simple steatosis to steatohepatitis and cirrhosis. Nonalcoholic steatohepatitis (NASH) is defined when liver steatosis is associated with inflammation, hepatocyte damage ...
Marica Cariello +2 more
doaj +1 more source
Targeting Farnesoid X Receptor in Tumor and the Tumor Microenvironment: Implication for Therapy
International Journal of Molecular Sciences, 2023 The farnesoid-X receptor (FXR), a member of the nuclear hormone receptor superfamily, can be activated by bile acids (BAs). BAs binding to FXR activates BA signaling which is important for maintaining BA homeostasis.
Miljana Nenkov +4 more
semanticscholar +1 more source
Stimulation of the farnesoid X receptor promotes M2 macrophage polarization
Frontiers in Immunology, 2023 FXR is a key molecule that modulates anti-inflammatory activity in the intestinal-liver axis. Although FXR has pleiotropic functions including regulation of liver inflammation and activation of macrophages, it remains unclear whether it is involved in ...
Thiranut Jaroonwitchawan +7 more
semanticscholar +1 more source
Current insights in molecular characterization of non-alcoholic fatty liver disease and treatment
Frontiers in Endocrinology, 2022 There is a continuously rising incidence of non-alcoholic fatty liver disease (NAFLD) around the world, which parallels the increasing incidence of metabolic diseases.
Wensheng Che +6 more
doaj +1 more source