Obeticholic acid for the treatment of primary biliary cholangitis in adult patients: clinical utility and patient selection. [PDF]
, 2016 Primary biliary cholangitis (PBC), previously known as primary biliary "cirrhosis", is a rare autoimmune liver disease characterized by the hallmark autoantibodies to mitochondrial antigens and immune-mediated destruction of small bile duct epithelial ...
Bowlus, Christopher L
core +3 more sources
Journal of Pharmacological Sciences, 2008 Farnesoid X receptor (FXR) controls the expression of critical genes in bile acid and cholesterol homeostasis. To study FXR and to develop a regulator of cholesterol, some nonsteroidal and steroidal ligands have been found in addition to endogenous ...
Takuo Suzuki +12 more
doaj +1 more source
Mechanisms underlying bone loss associated with gut inflammation [PDF]
, 2019 Patients with gastrointestinal diseases frequently suffer from skeletal abnormality, characterized by reduced bone mineral density, increased fracture risk, and/or joint inflammation.
Abu-Amer, Yousef, Arra, Manoj, Ke, Ke
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Nonalcoholic steatohepatitis pharmacotherapy and predictors of response: dual role of aminotransferases as biosensors of metabolism and biomarkers of histological improvement [PDF]
, 2019 Nonalcoholic steatohepatitis (NASH)—the severe histological form of nonalcoholic fatty liver disease (NAFLD)—is regarded as a major health problem worldwide (1,2).
Pirola, Carlos José +1 more
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Molecular tuning of farnesoid X receptor partial agonism
Nature Communications, 2019 The ligand-activated transcription factor farnesoid X receptor (FXR) acts as a cellular sensor for bile acids and is of interest as a drug target. Here the authors employ X-ray crystallography and NMR to characterize the molecular determinants of FXR ...
Daniel Merk +14 more
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BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis
Journal of Lipid Research, 2002 During the last three years there have been a plethora of publications on the liver X-activated receptors (LXRα, NR1H3, and LXRβ, NR1H2), the farnesoid X-activated receptor (FXR, NR1H4), and the pregnane X receptor (PXR, NR1I2) and the role these nuclear
Peter A. Edwards +2 more
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Farnesoid X receptor and fibroblast growth factor 15/19 as pharmacological targets
Liver Research, 2021 The farnesoid X receptor (FXR) is a nuclear receptor and transcriptional regulator activated by bile acids or synthetic FXR agonists. FXR is expressed highly in the liver and intestine where modulation of FXR critically regulates the expression of genes ...
S. Maliha, G. Guo
semanticscholar +1 more source
The role of lipid and lipoprotein metabolism in non-alcoholic fatty liver disease [PDF]
, 2017 Due to the epidemic of obesity across the world, nonalcoholic fatty liver disease (NAFLD) has become one of the most prevalent chronic liver disorders in children and adolescents.
Anania, Caterina +4 more
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Frontiers in Cell and Developmental Biology, 2021 Cholestasis is a kind of stressful syndrome along with liver toxicity, which has been demonstrated to be related to fibrosis, cirrhosis, even cholangiocellular or hepatocellular carcinomas.
Pei-Shan Wu +6 more
semanticscholar +1 more source
Regulation of inflammatory and lipid metabolism genes by eicosapentaenoic acid-rich oil[S]
Journal of Lipid Research, 2012 Omega-3-PUFAs, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are associated with prevention of various aspects of metabolic syndrome.
Peter J. Gillies +5 more
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