Results 1 to 10 of about 595,345 (120)
Molecular distribution in intradermal injection for transfer and delivery of therapeutics
Frontiers in Drug Delivery, 2023 Intradermal (ID) injection is a technique widely used in laboratorial and clinical applications. The boundary of the dome-like bleb formed during injection is assumed to represent the lateral extent of the injected material.
Emran O. Lallow +13 more
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Multiple gene editing in porcine embryos using a combination of microinjection, electroporation, and transfection methods [PDF]
Veterinary World, 2022 Background and Aim: Mosaicism – the presence of both wild-type and mutant alleles – is a serious problem for zygotic gene modification through gene editing using the Clustered regularly interspaced short palindromic repeats-Cas9 (CRISPR/ Cas9) system ...
Quynh Anh Le +8 more
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Cationic lipid-mediated intracellular delivery of antibodies into live cells
BioTechniques, 2008 The ability to introduce antibodies to live cells opens new insights to a wide range of applications, such as protein intracellular trafficking studies, protein interference studies with blocking antibodies, and live immunolabeling or protein ...
Claire O. Weill +2 more
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Pharmaceutics, 2022 Gene electrotransfer is one of the main non-viral methods for intracellular delivery of plasmid DNA, wherein pulsed electric fields are used to transiently permeabilize the cell membrane, allowing enhanced transmembrane transport.
Tina Vindiš +5 more
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Molecular Therapy: Nucleic Acids, 2013 RNA interference (RNAi) is a major tool for basic and applied investigations. However, obtaining RNAi data that have physiological significance requires investigation of regulations and therapeutic strategies in appropriate in vivo settings.
Sylvie Remaud +11 more
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Infrared Laser-Based Single Cell Permeabilization by Plasma Membrane Temperature Gradients
Membranes, 2022 Single cell microinjection provides precise tuning of the volume and timing of delivery into the treated cells; however, it also introduces workflow complexity that requires highly skilled operators and specialized equipment.
Allen L. Garner +2 more
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Central Asian Journal of Medical Sciences, 2016 Objectives: Chronic neutrophilic leukemia (CNL) is a rare, but distinct, entity within myeloproliferative neoplasms, characterized by splenomegaly, sustained mature neutrophilia, and absence of the Philadelphia chromosome. In 2013, oncogenic mutations in
Otgonbat Altangerel +2 more
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WDR7 up-regulation upon knocking down of neighboring non-coding RNA using siRNAs encapsulated in polyamidoamine dendrimers [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Breast cancer is the second leading cause of cancer death in females. Understanding molecular mechanisms in cancer cells compared with normal cells is crucial for diagnostic and therapeutic strategies. Long intergenic non-protein coding RNA,
Sara Kor +4 more
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Pharmaceutics, 2022 Gene transfer into primary immune cells as well as into cell lines is essential for scientific and therapeutical applications. One of the methods used for gene transfer is electroporation (EP).
Eivina Radzevičiūtė +4 more
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Molecules, 2023 Poly(amidoamine) (PAMAM) dendrimers have attracted considerable attention in the field of gene therapy due to their flexibility in introducing different functional moieties and reduced toxicity at low generations.
Seongyeon Kim +3 more
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