Results 141 to 150 of about 40,710 (290)
The Role of FXR in Disorders of Bile Acid Homeostasis
Physiology, 2008 As ligands for the nuclear receptor FXR, bile acids regulate their own synthesis, transport, and conjugation, thus protecting against bile acid toxicity. Recently, the role of genetic variants in FXR itself, FXR target genes, and regulators of FXR in the pathophysiology of the liver and intestine has become increasingly evident.
Eloranta, J J, Kullak-Ublick, G A
openaire +4 more sources
Cell Proliferation, EarlyView.Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen +11 more
wiley +1 more source
Farnesoid X Receptor Expression in Microscopic Colitis: A Potential Role in Disease Etiopathogenesis
GE: Portuguese Journal of Gastroenterology, 2017 Introduction: Microscopic colitis (MC) is a chronic inflammatory bowel disease with unclear etiology. Bile acid (BA) malabsorption has been described in MC patients.
Joana Torres +9 more
doaj +1 more source
Toward Understanding Philippine Trade in Services: A Demand Approach [PDF]
This article investigates the determinants of Philippine trade in commercial services, and makes an attempt to explain the historical trends and movements in aggregated services exports and imports in relation to variables such as income, relative price,
Barns, Jeremy R.
core
The FEBS Journal, EarlyView.Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano +10 more
wiley +1 more source
FXR Mediates Adenylyl Cyclase 8 Expression in Pancreatic β-Cells
Journal of Diabetes Research, 2019 Adenylyl cyclase 8 (ADCY8) and Farnesoid X Receptor (FXR) have been identified in pancreatic β-cells and play important roles in insulin secretion. But the mechanisms underlying with respect to the regulation of ADCY8 expression in β-cells, particularly ...
Xiangchen Kong +3 more
doaj +1 more source
Effect of elastic end rings on the eigenfrequencies of finite length thin cylindrical shells [PDF]
Effect of elastic end rings on eigenfrequencies of finite length thin cylindrical ...
Raheb, M. E.
core +1 more source
The emerging role of the Hippo signaling pathway in interorgan crosstalk
The FEBS Journal, EarlyView.Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song +2 more
wiley +1 more source
Scientific Reports, 2017 Farnesoid X receptor (FXR), a nuclear receptor for maintaining bile acid homeostasis, has been recognized as a tumor suppressor in enterohepatic tissues. However, its expression and functional role in non-small cell lung cancer (NSCLC) remain unclear. We
Wenjie You +5 more
doaj +1 more source
Joint default probabilities and country risk [PDF]
The assessment of country risk is of crucial importance for both developing countries and international lenders and investors. Many existing country risk approaches are opaque and heavily rely on subjective choices.
Hameeteman, Daphne, Scholtens, Bert
core +1 more source