Results 151 to 160 of about 24,047 (218)

Osteoarthritis Therapeutics: From Microenvironment Understanding to Regenerative Intervention—Current Advances and Future Perspectives

Orthopaedic Surgery, Volume 18, Issue 10, Page 2032-2044, October 2026.
This article outlines a paradigm shift in OA therapeutics, OA as a systemic disease of joint microenvironment imbalance. It synthesizes advances in targeting key pathological hubs—immune, metabolic, and senescent—and details novel regenerative strategies using engineered biomaterials and exosomes.
Yongbiao Meng, Shenghua Wu, Quanchun Liu
wiley   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

RT206 Couples Partial PPARα/γ Agonism with Ligand-Dependent Allosteric Potentiation of FXR Signaling in Liver Cells. [PDF]

Biomolecules
Leo M, Cerchia C, Laghezza A, Rinaldi F, Calleri E, Colantuoni V, Loiodice F, Sabatino L, Lavecchia A.   +8 more
europepmc   +1 more source

Bile Acid Metabolism as a Unifying Readout for Diet, Microbiome Function, and Gastrointestinal Disease

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Dietary components shape the gut microbiome, which modifies bile acids through transformations. The resulting bile acid pool is sensed by host receptors to regulate immunity, metabolism, and intestinal function. Targeted bile acid measurements provide a unifying readout to study diet‐microbiome interactions and to develop next‐generation dietary ...
Jason Dichter
wiley   +1 more source

Mechanism of FXR signaling: from liver inflammation to hepatocellular carcinoma. [PDF]

Biochem Biophys Rep
Qiuluo C, Guiqun H, Xue H, Ying Z.
europepmc   +1 more source

Pulsatile FXR activation: Timing bile acid-targeted therapy to physiology. [PDF]

Acta Pharmacol Sin
Jiao TY, Li YT, Gonzalez FJ, Xie C.
europepmc   +1 more source

The Polysaccharides from <i>Balanophora harlandii</i> Hook. Alleviated Alcoholic Steatohepatitis via Suppressing Bile Acid Synthesis Mediated by Intestinal FXR Activation. [PDF]

Nutrients
Xiao L, Chen J, Zhong W, Peng F, Yuan C.
europepmc   +1 more source

Transcriptional regulation of ubiquitin specific peptidase 2b by farnesoid X receptor and its implications in the pathogenesis of hepatocellular carcinoma. [PDF]

Am J Cancer Res
Ali W, Nadolny C, Zhang X, Chen Q, Hashmi SF, Huniti T, Rahman MM, Bozza L, Warila D, Deng R.   +9 more
europepmc   +1 more source

Screening and Determination of Biomarkers and Their Associated Active Components for Enhanced Therapeutic Effect of Exocarpium Citri Grandis-Folium Ginkgo Couplet on Liver Injury Caused by Hyperlipidemia via UPLC-TOF-MS and UPLC-MS. [PDF]

Drug Des Devel Ther
Liu C, Wu G, Wei X, Xiao G, Chen Z.
europepmc   +1 more source

Pharmacological Activation of FXR Attenuates Renal Fibrosis and Pyroptosis-Associated Signaling in Aldosterone-Infused Mice. [PDF]

J Inflamm Res
Gu T, Xu S, Jiang X, Ji Y.
europepmc   +1 more source