Results 131 to 140 of about 40,710 (290)

Hyodeoxycholic acid relieves neuropathic pain by activating farnesoid X receptor signaling

Journal of Advanced Research
Background: Neuropathic pain, is a chronic condition stemming from nervous system injuries. The farnesoid X receptor (FXR), primarily expressed in the liver and intestines, plays a crucial role in regulating bile acids and lipids metabolism.
Jiaqi Lin, Xuejiao Zeng, Zehua Su, Xin Li, Yongze Yu, Shuwen Qian, Qianhao Hou, Wenying Duan, Zetian Wang, Chunzheng Liu, Jinyuan Zhang, Changshun Huang, Lijun Liao   +12 more
doaj   +1 more source

Bile acid metabolism and sleep: Mechanistic interplay and clinical implications of the gut–liver–brain axis

Sleep Research, EarlyView.
Abstract The bidirectional interplay between sleep and metabolic homeostasis is fundamental to physiological health. While the roles of glucose and lipid metabolism in sleep regulation have been extensively characterized, bile acids (BAs), which are traditionally viewed as digestive surfactants, are emerging as critical metabolic messengers with ...
Yu Jiang, Shuangyan Li, Dhirendra Paudel, Miaoqin Tan, Bin Zhang   +4 more
wiley   +1 more source

Disordered Bile Acid Metabolism in Alcohol‐Related Hepatitis

Alimentary Pharmacology &Therapeutics, EarlyView.
Serum conjugated primary bile acids accumulate in alcohol‐related hepatitis due to downregulation of hepatocyte bile acid transporters. Hepatocyte growth factor is elevated in alcohol‐related hepatitis and downregulates BSEP expression. This detrimentally affects the hepatoprotective adaptive reduction in NTCP/increase in BSEP seen in cholestasis ...
Luke D. Tyson, Stephen Atkinson, Benjamin H. Mullish, Alexandros Pechlivanis, Michael Allison, Andrew Austin, Katie Chappell, Stuart J. Forbes, Ewan H. Forrest, Alastair M. Kilpatrick, Tong Liu, Laura Martinez‐Gili, Steven Masson, Mark J. W. McPhail, Joao Nunes, Paul Richardson, Daniel Rodrigo‐Torres, Stephen D. Ryder, Mark Wright, Vishal C. Patel, Nikhil Vergis, Elaine Holmes, Mark R. Thursz   +22 more
wiley   +1 more source

Hepatoprotective Effects of Cilnidipine in Cholestatic Liver Disease: Role of FXR and NRF2 Signalling

Journal of Experimental Pharmacology
Thamer Abdulla Mohammed,1 Munaf H Zalzala2 1Ministry of Health and Environment, The State Company for Marketing Drugs and Medical Appliances, Baghdad, Iraq; 2Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad ...
Mohammed TA, Zalzala MH
doaj  

Farnesoid X Receptor Regulated Sepsis‐Induced Abnormal Bile Acid Metabolism via the Fibroblast Growth Factor 15/Fibroblast Growth Factor Receptor 4 Pathway

Immunity, Inflammation and Disease
Objective The study aims to investigate the mechanism of Farnesoid X receptor (FXR) activation in sepsis‐induced abnormal bile acid metabolism and the metabolism status of each bile acid type.
Ziyang Zhou, Dan Xu, Liou Huang, Yuhui Cui, Hui Chen, Jianguo Tang   +5 more
doaj   +1 more source

Political Monetary Cycles and a New de facto Ranking of Central Bank Independence [PDF]

This paper examines the extent to which monetary policy is manipulated for political purposes by testing for the presence of political monetary cycles between 1972 and 2001.
Alpanda, Sami, Honig, Adam
core   +1 more source

Correlation of Bile Acid Dynamics to Bulevirtide Response and Disease Severity in Patients With Hepatitis D

Alimentary Pharmacology &Therapeutics, EarlyView.
Bulevirtide increases bile acid levels in most patients; however, changes in bile acids do not predict virological response or adverse events, nor do they reflect treatment adherence. After discontinuation of bulevirtide, bile acid levels rapidly decline.
Marlene Hintersteininger, Michael Schwarz, Philipp Schwabl, Lukas Hartl, Lorenz Balcar, Benedikt Silvester Hofer, Georg Kramer, Christian Sebesta, Paul Thöne, Patrik Attalla, Michael Gschwantler, Michael Trauner, Mattias Mandorfer, Thomas Reiberger, Mathias Jachs   +14 more
wiley   +1 more source

FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model.

PLoS ONE, 2012
The farnesoid X receptor (FXR) is expressed predominantly in tissues exposed to high levels of bile acids and controls bile acid and lipid homeostasis. FXR(-/-) mice develop hepatocellular carcinoma (HCC) and show an increased prevalence for intestinal ...
Ulrich Deuschle, Julia Schüler, Andreas Schulz, Thomas Schlüter, Olaf Kinzel, Ulrich Abel, Claus Kremoser   +6 more
doaj   +1 more source

FXR Acts as a Metastasis Suppressor in Intrahepatic Cholangiocarcinoma by Inhibiting IL-6-Induced Epithelial-Mesenchymal Transition

Cellular Physiology and Biochemistry, 2018
Background/Aims: Intrahepatic cholangiocarcinoma (ICC) is a complicated condition, with difficult diagnosis and poor prognosis. The expression and clinical significance of the farnesoid X receptor (FXR), an endogenous receptor of bile acids, in ICC is ...
Bei Lv, Lijie Ma, Wenqing Tang, Peixin Huang, Biwei Yang, Lingxiao Wang, She Chen, Qiang Gao, Si Zhang, Jinglin Xia   +9 more
doaj   +1 more source

Hydrodynamic lift on bound vesicles

, 1999
Bound vesicles subject to lateral forces such as arising from shear flow are investigated theoretically by combining a lubrication analysis of the bound part with a scaling approach to the global motion.
D. A. Hammer, E. Evans, I. Cantat, I. Durand, J. O. Rädler, M. Kraus, P. Olla, R. Bruinsma, R. Lipowsky, R. Lipowsky, R. M. Servuss, U. Seifert, U. Seifert, Udo Seifert   +13 more
core   +1 more source