Results 111 to 120 of about 24,047 (218)

Deciphering the nuclear bile acid receptor FXR paradigm

, 2010
Originally called retinoid X receptor interacting protein 14 (RIP14), the farnesoid X receptor (FXR) was renamed after the ability of its rat form to bind supra-physiological concentrations of farnesol.
Modica, Salvatore, Moschetta, Antonio, Gadaleta, Raffaella M, Gadaleta, Raffaella   +3 more
core   +1 more source

Helicobacter hepaticus infection promotes hepatitis and preneoplastic foci in farnesoid X receptor (FXR) deficient mice.

PLoS ONE, 2014
Farnesoid X receptor (FXR) is a nuclear receptor that regulates bile acid metabolism and transport. Mice lacking expression of FXR (FXR KO) have a high incidence of foci of cellular alterations (FCA) and liver tumors.
Alton G Swennes, Alexander Sheh, Nicola M A Parry, Sureshkumar Muthupalani, Kvin Lertpiriyapong, Alexis García, James G Fox   +6 more
doaj   +1 more source

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

Structural basis for the asymmetric binding of coactivator SRC1 to FXR-RXRα and allosteric communication within the complex

Communications Biology
Farnesoid X receptor (FXR) is a promising target for treatment of metabolic associated fatty liver disease (MAFLD). In this study, we employed an integrative approach to investigate the interaction between FXR-RXRα-DNA complex and the entire coactivator ...
Yanan Sheng, Yaoting Guo, Beibei Zhao, Mingze Sun, Yan Dong, Yue Yin, Yanwu Wang, Chao Peng, Yong Xu, Na Wang, Jinsong Liu   +10 more
doaj   +1 more source

Effects of GLP‐1 agonists on the gut microbiota in type 2 diabetes mellitus: a systematic review

The FEBS Journal, EarlyView.
This systematic review evaluated 17 studies (12 preclinical and five clinical) on GLP‐1 receptor agonists in type 2 diabetes, demonstrating effects on the gut microbiota and metabolic improvement. The studies showed an increase in Bacteroidetes, Lactobacillus, and Akkermansia, and a reduction in Firmicutes.
Ranicleide Santos Dantas, Lucas Vinícius Souza Santos, André Gustavo Carvalho de Oliveira, Marina dos Santos Barreto, Deise Maria Rego Rodrigues Silva, Pedro Henrique Macedo Moura, Eloia Emanuelly Dias Silva, Ronaldy Santana Santos, Lucas Alves da Mota Santana, Rajiv Gandhi Gopalsamy, Adriana Gibara Guimarães, Lysandro Pinto Borges   +11 more
wiley   +1 more source

FXR Regulates Liver Repair after CCl4-Induced Toxic Injury

, 2010
Liver repair is key to resuming homeostasis and preventing fibrogenesis as well as other liver diseases. Farnesoid X receptor (FXR, NR1H4) is an emerging liver metabolic regulator and cell protector.
Meng, Zhipeng, Wang, Lin, Pan, Hao, Forman, Barry M., Huang, Wendong, Wang, Yandong, Liu, Lucy, Liu, Nian, Jin, Wen, Wagman, Lawrence   +9 more
core   +1 more source

STUDY OF FXR IN PRIMARY HUMAN HEPATOCYTES AND FXR REGULATED BA HOMEOSTASIS IN PARENTERAL NUTRITION ASSOCIATED LIVER DISEASES [PDF]

, 2014
Farnesoid X receptor (FXR, NR1H4) is a ligand activated transcription factor belonging to the nuclear receptor (NR) superfamily, and is highly expressed in the liver, intestine, and kidney, in both humans and rodents.
Zhan, Le
core   +1 more source

Farnesoid X Receptor Regulated Sepsis‐Induced Abnormal Bile Acid Metabolism via the Fibroblast Growth Factor 15/Fibroblast Growth Factor Receptor 4 Pathway

Immunity, Inflammation and Disease
Objective The study aims to investigate the mechanism of Farnesoid X receptor (FXR) activation in sepsis‐induced abnormal bile acid metabolism and the metabolism status of each bile acid type.
Ziyang Zhou, Dan Xu, Liou Huang, Yuhui Cui, Hui Chen, Jianguo Tang   +5 more
doaj   +1 more source

Allosteric modulation of the farnesoid X receptor by a small molecule

Scientific Reports, 2018
The bile acid activated transcription factor farnesoid X receptor (FXR) regulates numerous metabolic processes and is a rising target for the treatment of hepatic and metabolic disorders.
Matthias Gabler, Jan Kramer, Jurema Schmidt, Julius Pollinger, Julia Weber, Astrid Kaiser, Frank Löhr, Ewgenij Proschak, Manfred Schubert-Zsilavecz, Daniel Merk   +9 more
doaj   +1 more source

Pemafibrate Improves Cholestatic Markers Regardless of the Presence of Primary Biliary Cholangitis

Hepatology Research, EarlyView.
Pemafibrate improves liver function markers related to bile flow in primary biliary cholangitis (PBC), but whether this effect is disease‐specific remains unclear. In this study, pemafibrate reduced these markers in patients with and without PBC, suggesting broader effects on bile flow beyond PBC.
Ryohei Tanigawa, Yoshiyuki Ueno, Hirokazu Takahashi, Ayumi Saito, Hideki Suganami, Atsushi Tanaka   +5 more
wiley   +1 more source