Results 71 to 80 of about 24,047 (218)

Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease

, 2020
Background: We previously showed that activation of the bile salt nuclear receptor Farnesoid X Receptor (FXR) protects against intestinal inflammation in mice. Reciprocally, these inflammatory mediators may decrease FXR activation.
Cisca Wijmenga, Rian M Nijmeijer, Saskia W C Van Mil, Gerard Dijkstra, Pieter C F Stokkers, Hein W Verspaget, Raffaella M Gadaleta, C Janneke Van Der Woude, A Crusius, Daan W Hommes, Janneke M Stapelbroek, Karel J Van Erpecum, Bas Oldenburg, Rinse K Weersma, Marguerite E I Schipper, Dirk J De Jong, Adriaan A Van Bodegraven, J Bart   +17 more
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Study of Novel FXR Ligands [PDF]

, 2017
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Candidate: Mgr. Jana Jeřábková Consultant: prof. PharmDr. Petr Pávek, Ph.D. Title of Thesis: Study of Novel FXR Ligands Human farnesoid X receptor (
Jeřábková, Jana
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Hepatocarcinogenesis in FXR-/- Mice Mimics Human HCC Progression That Operates through HNF1 alpha Regulation of FXR Expression

, 2012
Farnesoid X receptor (FXR) (nuclear receptor subfamily 1, group H, member 4) is a member of nuclear hormone receptor superfamily, which plays essential roles in metabolism of bile acids, lipid, and glucose.
Liu, Xiyong, Zhang, Yunfeng, Lai, Lily, Lou, Guiyu, Zhou, Weiping, Meng, Zhipeng, Forman, Barry M., Zhang, Lisheng, Huang, Wendong, Yen, Yun, Xu, Rongzhen, Xu, Zhonggao, Liu, Nian, Wang, Xiaoqiong   +13 more
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FXR, a target for different diseases [PDF]

, 2008
Great progress has been made in the understanding of the physiological roles of the nuclear receptor farnesoid X receptor (FXR) during the last several years.
Wang, Yan-Dong, Huang, Wendong, Chen, Wei-Dong   +2 more
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Fxr deficient mouse line generation.

, 2013
(A) Schematic diagram of the Fxr gene and targeting vector. (B) Southern blot analyses of 8 targeted ES cell clones (lane 1–8) and a wild type control clone (lane 9), using HindIII restriction enzyme, resulting in wild type fragments of 10649 bp and ...
Melker Göransson (583827), Majlis Hermansson (583826), Mikael Bjursell (274867), Gerhard Böttcher (483183), Marianne Wedin (583825), Krister Bamberg (583828), Daniel Lindén (483184), Jan Oscarsson (42119), Therése Admyre (5659573), Mohammad Bohlooly-Y (217638)   +9 more
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Evidence for the involvement of FXR signaling in ovarian granulosa cell function

The Journal of Reproduction and Development, 2018
Farnesoid X receptor (FXR) is mainly present in enterohepatic tissues and regulates cholesterol, lipid, and glucose homeostasis in coordination with target genes such as SHP and FABP6.
Kentaro TAKAE, Mizuho NAKATA, Takafumi WATANABE, Hiroshi SASADA, Hiroshi FUJII, Ikuo TOMIOKA   +5 more
doaj   +1 more source

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk

, 2014
The nuclear bile acid receptor farnesoid X receptor (FXR) is an important transcriptional regulator of bile acid, lipid, and glucose metabolism. FXR is highly expressed in the liver and intestine and controls the synthesis and enterohepatic circulation ...
Patrice, Alexandre, Christophe Rachez, Berthier, Alexandre, Alexandre, Jeremy, Colin, Sophie, Dehondt, Helene, Bart Staels, François Pattou, Diemer, Helene, Alexandre Berthier, Sophie Colin, Anthony Lucas, Prawitt, Janne, Gheeraert, Celine, Rachez, Christophe, Jelena Kamilic, Lien, Fleur, Hélène Diemer, Lucas, Anthony, Kamilic, Jelena, Lefebvre, Philippe, Albert K. Groen, Porez, Geoffrey, Alexandre Patrice, Philippe Lefebvre, Maheul Ploton, Geoffrey Porez, Janne Prawitt, Staels, Bart, Hélène Dehondt, Groen, Albert, Emmanuel Bouchaert, Céline Gheeraert, Bouchaert, Emmanuel, Pattou, Francois, Jeremy Alexandre, Ploton, Maheul, Fleur Lien, Alain Van Dorsselaer, Groen, Albert K., Van Dorsselaer, Alain   +40 more
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FXR signaling in metabolic disease [PDF]

, 2008
Farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, has been shown to be important in controlling numerous metabolic pathways; these include roles in maintaining bile acid, lipid and glucose homeostasis, in preventing intestinal ...
Edwards, Peter A., Zhang, Yanqiao
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Farnesoid X receptor represses hepatic lipase gene expression

Journal of Lipid Research, 2004
The farnesoid X receptor (FXR) is a nuclear receptor that regulates gene expression in response to bile acids (BAs). FXR plays a central role in BA, cholesterol, and lipoprotein metabolism.
Audrey Sirvent, Adrie J.M. Verhoeven, Hans Jansen, Vladimir Kosykh, Raphaël J. Darteil, Dean W. Hum, Jean-Charles Fruchart, Bart Staels   +7 more
doaj   +1 more source

Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR)

, 2013
Bile acid metabolism is intimately linked to the control of energy homeostasis and glucose and lipid metabolism. The nuclear receptor farnesoid X receptor (FXR) plays a major role in the enterohepatic cycling of bile acids, but the impact of nutrients on
Alexandre, Jérémy, Sandrine Caron, Dehondt, Helene, Mazuy, Claire, Eeckhoute, Jerome, Houde, Sandrine, Bart Staels, Muhr Tailleux, Anne, Tony Lefebvre, Jérôme Eeckhoute, Gheeraert, Celine, Wahiba Berrabah, Lefebvre, Philippe, Philippe Lefebvre, Aumercier, Pierrette, Maheul Ploton, Pierrette Aumercier, Claire Mazuy, Staels, Bart, Hélène Dehondt, Céline Gheeraert, Emmanuel Bouchaert, Bouchaert, Emmanuel, Lefebvre, Tony, Berrabah, Wahiba, Ploton, Maheul, Anne Tailleux, Jérémy Alexandre   +27 more
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