Results 11 to 20 of about 40,710 (290)

FXR: structures, biology, and drug development for NASH and fibrosis diseases

Acta Pharmacologica Sinica, 2022
Siyu Tian, Shu-ming Chen, Chen Pan, Yong Li   +3 more
exaly   +2 more sources

The Effects of PPAR Agonists on Atherosclerosis and Nonalcoholic Fatty Liver Disease in ApoE−/−FXR−/− Mice [PDF]

Endocrinology and Metabolism, 2021
Background Farnesoid X receptor (FXR), a bile acid–activated nuclear receptor, is a potent regulator of glucose and lipid metabolism as well as of bile acid metabolism.
Yenna Lee, Bo-Rahm Kim, Geun-Hyung Kang, Gwan Jae Lee, Young Joo Park, Haeryoung Kim, Hak Chul Jang, Sung Hee Choi   +7 more
doaj   +1 more source

FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

Nature, 2022
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting enzyme 2 (ACE2)^ 1 , could represent a new chemoprophylactic approach for COVID-19 that complements vaccination^ 2 , 3 .
T. Brevini, M. Maes, G. Webb, Binu V. John, C. Fuchs, G. Buescher, Lu Wang, C. Griffiths, Marnie L Brown, W. Scott, Pehuén Pereyra-Gerber, W. Gelson, S. Brown, Scott Dillon, D. Muraro, Joanne Sharp, M. Neary, H. Box, Lee M. Tatham, James P. Stewart, P. Curley, H. Pertinez, S. Forrest, P. Mlcochova, Sagar S. Varankar, M. Darvish-Damavandi, V. Mulcahy, R. Kuc, Thomas L. Williams, James A. Heslop, D. Rossetti, Olivia C. Tysoe, V. Galanakis, M. Vilà-González, Thomas W M Crozier, Johannes Bargehr, S. Sinha, S. Upponi, C. Fear, L. Swift, K. Saeb‐Parsy, S. Davies, A. Wester, H. Hagström, E. Melum, D. Clements, Peter Humphreys, Joanne Herriott, Edyta Kijak, H. Cox, Chloe Bramwell, A. Valentijn, Christopher J. R. Illingworth, B. Dahman, Dustin Bastaich, R. Ferreira, Thomas Marjot, Eleanor Barnes, A. Moon, A. Barritt, Ravindra K. Gupta, S. Baker, A. Davenport, G. Corbett, V. Gorgoulis, S. J. Buczacki, J. Lee, N. Matheson, M. Trauner, A. Fisher, Paul Gibbs, A. Butler, C. Watson, G. Mells, G. Dougan, A. Owen, A. Lohse, L. Vallier, F. Sampaziotis   +78 more
semanticscholar   +1 more source

Improving glucose and lipids metabolism: drug development based on bile acid related targets

Cell Stress, 2021
Bariatric surgery is one of the most effective treatment options for severe obesity and its comorbidities. However, it is a major surgery that poses several side effects and risks which impede its clinical use.
Hanchen Shen, Lili Ding, Mehdi Baig, Jingyan Tian, Yang Wang, Wendong Huang   +5 more
doaj   +1 more source

Gut microbiota-bile acid crosstalk regulates murine lipid metabolism via the intestinal FXR-FGF19 axis in diet-induced humanized dyslipidemia

Microbiome, 2023
Background Diet-induced dyslipidemia is linked to the gut microbiota, but the causality of microbiota-host interaction affecting lipid metabolism remains controversial.
Hongtao Xu, Fang Fang, Kaizhang Wu, Jiangping Song, Yaqian Li, Xingyu Lu, Juncheng Liu, Liuyang Zhou, Wenqing Yu, Fei Yu, Jie Gao   +10 more
semanticscholar   +1 more source

Bile acid dysmetabolism in inflammatory bowel diseases

Alʹmanah Kliničeskoj Mediciny, 2023
Aim: To summarize the state-of-the-art data on the molecular mechanisms of bile acid (BA) synthesis and absorption, their impaired absorption and receptor-dependent signaling, as well as on the effects of the gut microbiota on BA metabolism in ...
Daria A. Kuznetsova, Sergey V. Lapin, Irina V. Gubonina   +2 more
doaj   +1 more source

Atorvastatin Induces FXR and CYP7A1 Activation as a Result of the Sequential Action of PPARγ/PGC-1α/HNF-4α in Hep3B Cells

The Korean Journal of Gastroenterology, 2021
Backgrounds/Aims: PPARγ, farnesoid X receptor (FXR) and CYP7A1 are associated with solubility of bile. This study was performed to understand a mechanism and interactions of statin-induced PPARγ, PGC-1α and HNF-4α related to the statin-induced activation
Jin Lee, Eun Mi Hong, Jang Han Jung, Se Woo Park, Sang Pyo Lee, Dong Hee Koh, Hyun Joo Jang, Sea Hyub Kae   +7 more
doaj   +1 more source

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]

, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco, Francis, Heather, Kennedy, Lindsey, Kundu, Debjyoti, Meadows, Vik   +4 more
core   +1 more source

Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis

International Journal of Molecular Sciences, 2022
Bile acids (BAs) are a group of amphiphilic molecules consisting of a rigid steroid core attached to a hydroxyl group with a varying number, position, and orientation, and a hydrophilic side chain.
T. Katafuchi, M. Makishima
semanticscholar   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source