Results 21 to 30 of about 24,047 (218)

Immunomodulatory functions of FXR

, 2022
The Farnesoid-x-receptor (FXR) is a bile acids sensor activated in humans by primary bile acids. FXR is mostly expressed in liver, intestine and adrenal glands but also by cells of innate immunity, including macrophages, liver resident macrophages, the ...
Fiorucci, Stefano, Distrutti, Eleonora, Ricci, Patrizia, Stefano Fiorucci, Patrizia Ricci, Michele Biagioli, Zampella, Angela, Angela Zampella, Biagioli, Michele, Eleonora Distrutti   +9 more
core   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Regulation of hepatic heme synthesis by drugs, bile acids and nutrition : a transcriptional network regulating [delta]-aminolevulinic acid synthase 1 (ALAS1) [PDF]

, 2008
ALAS1 is the rate limiting enzyme of heme synthesis. It is highly inducible in liver in cases of increased heme demand, such as drug metabolism or in inducible hepatic porphyrias.
Peyer, Anne-Kathrin
core   +1 more source

TDG is a novel tumor suppressor of liver malignancies

Molecular & Cellular Oncology, 2020
In a recent publication, we demonstrated that conditional deletion of the gene encoding thymine DNA glycosylase (TDG) leads to a late onset of hepatocellular carcinoma (HCC).
Haider M. Hassan, Majdina Isovic, Michael Tully Underhill, Joseph Torchia   +3 more
doaj   +1 more source

Coconut milk gavage enhanced fecal bile excretion by modulating hepatic Fxr expression but failed to improve fasting serum cholesterol profile in C57BL/6 mice

Oilseeds and fats, crops and lipids, 2020
The consumption of coconut milk has long been regarded as detrimental to cardiovascular health due to its high saturated fatty acid content. Contradictorily, emerging evidences have highlighted that the fatty acids in coconut lipids, which comprise ...
Wong Hong Kin, Choo Quok Cheong, Chew Choy Hoong   +2 more
doaj   +1 more source

Amarogentin relieves cholestatic liver injury caused by ANIT in rats by regulating the FXR and Nrf2 pathways [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Cholestasis, a hepatic disorder characterized by impaired bile secretion, drives progressive liver damage, fibrosis, failure, and even death. This study explores how amarogentin (AG) ameliorates cholestatic liver injury in rats induced by α-
Wenxiang Wang, Wei Xiong, Jingxin Mao, Chunyu Chen   +3 more
doaj   +1 more source

Prevention of spontaneous hepatocarcinogenesis in FXR null mice by intestinal specific FXR re-activation. [PDF]

, 2015
Farnesoid X receptor (FXR) is the master regulator of bile acid (BA) homeostasis because it controls BA synthesis, influx, efflux, and detoxification in the gut/liver axis. Deregulation of BA homeostasis has been linked to hepatocellular carcinoma (HCC),
Modica S, D'Orazio A, Morgano A, MOSCHETTA, ANTONIO, Vacca M, Degirolamo C, Parini P, Di Tullio G, Kannisto K   +8 more
core   +1 more source

Bile Acid Network and Vascular Calcification-Associated Diseases: Unraveling the Intricate Connections and Therapeutic Potential

Clinical Interventions in Aging, 2023
Cui Wang,1,* Qing Ma,2,* Xijie Yu1 1Laboratory of Endocrinology & Metabolism/Department of Endocrinology & Metabolism, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, People’s Republic of China ...
Wang C, Ma Q, Yu X
doaj  

Ablation of liver Fxr results in an increased colonic mucus barrier in mice

JHEP Reports, 2021
Background & Aims: The interorgan crosstalk between the liver and the intestine has been the focus of intense research. Key in this crosstalk are bile acids, which are secreted from the liver into the intestine, interact with the microbiome, and upon
Noortje Ijssennagger, Kristel S. van Rooijen, Stefanía Magnúsdóttir, José M. Ramos Pittol, Ellen C.L. Willemsen, Marcel R. de Zoete, Matthijs J.D. Baars, Paul B. Stege, Carolina Colliva, Roberto Pellicciari, Sameh A. Youssef, Alain de Bruin, Yvonne Vercoulen, Folkert Kuipers, Saskia W.C. van Mil   +14 more
doaj   +1 more source

FXR modulators and cholestatic diseases | [Modulatori di FXR e patologie colestatiche]

, 2021
Riassunto. Il recettore nucleare Farnesoide X (FXR) è un recettore nucleare degli acidi biliari la cui attivazione sopprime la sintesi degli acidi biliari, stimola la loro escrezione nella bile e ne inibisce l’uptake negli epatociti.
Ridola L., Alvaro D., Venere R., Bragazzi M. C.   +3 more
core   +1 more source