Results 71 to 80 of about 24,275 (247)

Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis[S]

Journal of Lipid Research, 2011
Aldo-keto reductase 1B7 (AKR1B7) is proposed to play a role in detoxification of by-products of lipid peroxidation. In this article, we show that activation of the nuclear receptor farnesoid X receptor (FXR) induces AKR1B7 expression in the liver and ...
Xuemei Ge, Liya Yin, Huiyan Ma, Tiangang Li, John Y.L. Chiang, Yanqiao Zhang   +5 more
doaj   +1 more source

Administration of Vitamin D Metabolites Affects RNA Expression of Xenobiotic Metabolising Enzymes and Function of ABC Transporters in Rats [PDF]

, 2019
From studies on different species and in cell culture systems, it has been suggested that vitamin D metabolites might affect themetabolism and elimination of xenobiotics.
Hansen, Kathrin, Klumpp, Karoline, Lange, Frauke, Lifschitz, Adrian Luis, Maté, María Laura, Muscher-Banse, Alexandra S., Schnepel, Nadine, Wilkens, Mirja   +7 more
core   +1 more source

Loss of small heterodimer partner expression in the liver protects against dyslipidemias⃞

Journal of Lipid Research, 2009
Multiple studies suggest increased conversion of cholesterol to bile acids by cholesterol 7α-hydroxylase (CYP7A1) protects against dyslipidemia and atherosclerosis.
Helen B. Hartman, KehDih Lai, Mark J. Evans   +2 more
doaj   +1 more source

High temperature and humidity in the environment disrupt bile acid metabolism, the gut microbiome, and GLP-1 secretion in mice

Communications Biology
High temperature and humidity in the environment are known to be associated with discomfort and disease, yet the underlying mechanisms remain unclear.
Song Chen, Zongren Hu, Jianbang Tang, Haipeng Zhu, Yuhua Zheng, Jiedong Xiao, Youhua Xu, Yao Wang, Yi Luo, Xiaoying Mo, Yalan Wu, Jianwen Guo, Yongliang Zhang, Huanhuan Luo   +13 more
doaj   +1 more source

Targeting Farnesoid X receptor (FXR) for developing novel therapeutics against cancer

Molecular Biomedicine, 2021
Cancer is one of the lethal diseases that arise due to the molecular alterations in the cell. One of those alterations associated with cancer corresponds to differential expression of Farnesoid X receptor (FXR), a nuclear receptor regulating bile ...
Sosmitha Girisa, Sahu Henamayee, Dey Parama, Varsha Rana, Uma Dutta, Ajaikumar B. Kunnumakkara   +5 more
doaj   +1 more source

Bile acids at the cross-roads of gut microbiome–host cardiometabolic interactions [PDF]

, 2017
This work is supported in part by the APC Microbiome Institute (under Science Foundation Ireland [SFI] Grant Number: SFI/12/RC/2273) and by Enterprise Ireland Commercialization Fund (Contract Reference: CF/2013/3030A/B).peer-reviewedWhile basic and ...
Caplice, Noel M, Ryan, Paul M, STANTON, CATHERINE   +2 more
core   +3 more sources

Farnesoid X Receptor an Emerging Target to Combat Obesity [PDF]

Digestive Diseases, 2017
Obesity and its associated diseases, including type 2 diabetes, have reached epidemic levels worldwide. However, available treatment options are limited and ineffective in managing the disease. There is therefore an urgent need for the development of new pharmacological solutions. The bile acid (BA) Farnesoid X receptor (FXR) has recently emerged as an
C Daniel, De Magalhaes Filho, Michael, Downes, Ronald M, Evans   +2 more
openaire   +2 more sources

The relationship between gut microbiota and spontaneous bacterial peritonitis in patients with liver cirrhosis - a literature review [PDF]

, 2019
Gut microbiota is an essential component in the pathogenesis of liver cirrhosis and its complications. There is a direct relationship between the gut and the liver called the gutliver axis through which bacteria can reach the liver through the portal ...
Fierbinteanu Braticevici, Carmen, Mazilu, Laura, Motofei, Catalina, Pantea Stoian, Anca Mihaela, Parepa, Irinel R., Paunica, Mihai, Popoiag, Roxana-Emanuela, Serban, Laura M., Suceveanu, Adrian P., Suceveanu, Andra I.   +9 more
core   +3 more sources

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, EarlyView.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source

Mangrove Tirucallane- and Apotirucallane-Type Triterpenoids: Structure Diversity of the C-17 Side-Chain and Natural Agonists of Human Farnesoid/Pregnane–X–Receptor

Marine Drugs, 2018
Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10),
Zhong-Ping Jiang, Zhi-Lin Luan, Ruo-Xi Liu, Qun Zhang, Xiao-Chi Ma, Li Shen, Jun Wu   +6 more
doaj   +1 more source