Results 61 to 70 of about 6,800,049 (185)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Targeting Farnesoid X receptor (FXR) for developing novel therapeutics against cancer

Molecular Biomedicine, 2021
Cancer is one of the lethal diseases that arise due to the molecular alterations in the cell. One of those alterations associated with cancer corresponds to differential expression of Farnesoid X receptor (FXR), a nuclear receptor regulating bile ...
Sosmitha Girisa, Sahu Henamayee, Dey Parama, Varsha Rana, Uma Dutta, Ajaikumar B. Kunnumakkara   +5 more
doaj   +1 more source

Normal cholestanol in a genetically confirmed cerebrotendious xanthomatosis case presenting as neonatal jaundice

JPGN Reports, EarlyView.
Abstract Cerebrotendinous xanthomatosis (CTX) is a treatable genetic disorder associated with deficiency of the sterol 27‐hydroxylase enzyme (CYP27A1), important in bile acid synthesis. CTX may present in the newborn period as hepatic jaundice/cholestasis, that can resolve or can progress to fatal liver disease.
Andrea E. DeBarber, Maya Fowler, P. Barton Duell, Eric Dybbro   +3 more
wiley   +1 more source

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology & Autoimmunity
Background The farnesoid X receptor (FXR) is a nuclear receptor that regulates bile acid, lipid, and glucose metabolism. Its role in uric acid (UA) homeostasis, however, remains unclear.
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
doaj   +1 more source

Bile acids: New regulators of the cardiometabolic crosstalk

Pharmacological Research
Obesity and associated metabolic disorders are major drivers of cardiovascular disease worldwide. Bile acids are now recognized as endocrine signaling molecules that coordinate metabolic, immune, and cardiovascular homeostasis, extending their ...
Stefan Wolf, Marisa Nagler, Elena Osto
doaj   +1 more source

Mangrove Tirucallane- and Apotirucallane-Type Triterpenoids: Structure Diversity of the C-17 Side-Chain and Natural Agonists of Human Farnesoid/Pregnane–X–Receptor

Marine Drugs, 2018
Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10),
Zhong-Ping Jiang, Zhi-Lin Luan, Ruo-Xi Liu, Qun Zhang, Xiao-Chi Ma, Li Shen, Jun Wu   +6 more
doaj   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Farnesoid X receptor (FXR) activation induces the antioxidant protein metallothionein 1 expression in mouse liver

, 2019
supplemental data for： Farnesoid X receptor (FXR) activation induces the antioxidant protein metallothionein 1 expression in mouse ...
WEN SU (8063273)
core   +1 more source

Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding.

PLoS ONE, 2012
Farnesoid X receptor (FXR) is a nuclear receptor and a key regulator of liver cholesterol and triglyceride homeostasis. Scavenger receptor class B type I (SR-BI) is critical for reverse cholesterol transport (RCT) by transporting high-density lipoprotein
Guodong Li, Ann M Thomas, Jessica A Williams, Bo Kong, Jie Liu, Yuka Inaba, Wen Xie, Grace L Guo   +7 more
doaj   +1 more source

Role of Farnesoid X Receptor in the Pathogenesis of Respiratory Diseases

Canadian Respiratory Journal, 2020
Farnesoid X receptor (FXR) is a bile acid receptor encoded by the Nr1h4 gene. FXR plays an important role in maintaining the stability of the internal environment and the integrity of many organs, including the liver and intestines. The expression of FXR
Jin-nan Wu, Jian-rong Chen, Jin-liang Chen   +2 more
doaj   +1 more source