Results 81 to 90 of about 6,800,049 (185)
, 2018 The cancerogenic potential of primary human Cholangioracinoma cells is inhibited by Obeticholic Acid, a Farnesoid X Receptor (FXR ...
Colantonio M. +17 more
core +1 more source
Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis
Nature Communications, 2016 Neonatal cholestasis is a result of elevated bile acid levels, and is associated with mutations in genes regulating bile acid homeostasis. Here the authors identify mutations in the bile acid sensing farnesoid X receptor in four individuals with neonatal
Natalia Gomez-Ospina +28 more
doaj +1 more source
Effects of GLP‐1 agonists on the gut microbiota in type 2 diabetes mellitus: a systematic review
The FEBS Journal, EarlyView.This systematic review evaluated 17 studies (12 preclinical and five clinical) on GLP‐1 receptor agonists in type 2 diabetes, demonstrating effects on the gut microbiota and metabolic improvement. The studies showed an increase in Bacteroidetes, Lactobacillus, and Akkermansia, and a reduction in Firmicutes.
Ranicleide Santos Dantas +11 more
wiley +1 more source
Pemafibrate Improves Cholestatic Markers Regardless of the Presence of Primary Biliary Cholangitis
Hepatology Research, EarlyView.Pemafibrate improves liver function markers related to bile flow in primary biliary cholangitis (PBC), but whether this effect is disease‐specific remains unclear. In this study, pemafibrate reduced these markers in patients with and without PBC, suggesting broader effects on bile flow beyond PBC.
Ryohei Tanigawa +5 more
wiley +1 more source
Progesterone Metabolites as Farnesoid X Receptor Inhibitors
, 2015 Sulfated progesterone metabolites rise 100-fold in the third trimester of human pregnancy and have been shown to be elevated further in the gestational disorder intrahepatic cholestasis of pregnancy (ICP).
Abu-Hayyeh, Shadi, Williamson, Catherine
core +1 more source
Bile acid receptors and gastrointestinal functions
Liver Research, 2019 Bile acids modulate several gastrointestinal (GI) functions including electrolyte secretion and absorption, gastric emptying, and small intestinal and colonic motility.
Alexander L. Ticho +4 more
doaj +1 more source
GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms
Obesity Reviews, EarlyView.ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani +8 more
wiley +1 more source
Obesity Reviews, EarlyView.ABSTRACT Background Gut microbiota‐derived metabolites are emerging as potential mediators between obesity and cardiometabolic conditions. While weight loss interventions modify microbiota composition, their effects on systemic microbial metabolites remain unclear.
Fernando Q. Iorra +5 more
wiley +1 more source
Obesity Reviews, EarlyView.ABSTRACT Bariatric surgery (BS) has short‐ and medium‐term benefits in improving metabolic syndrome (MetS) components, but its long‐term impact remains incompletely characterized. This systematic review and meta‐analysis aimed to quantify the long‐term effects of BS (≥ 5 years) on fasting blood glucose (FBG), HDL cholesterol, triglycerides (TG), waist ...
Bernardo Paz Barboza +7 more
wiley +1 more source
Obesity Reviews, EarlyView.ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang +4 more
wiley +1 more source