Results 81 to 90 of about 24,275 (247)

Role of Farnesoid X Receptor in the Pathogenesis of Respiratory Diseases

Canadian Respiratory Journal, 2020
Farnesoid X receptor (FXR) is a bile acid receptor encoded by the Nr1h4 gene. FXR plays an important role in maintaining the stability of the internal environment and the integrity of many organs, including the liver and intestines. The expression of FXR
Jin-nan Wu, Jian-rong Chen, Jin-liang Chen   +2 more
doaj   +1 more source

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans [PDF]

, 2016
Bile acids are synthesized from cholesterol in the liver and subjected to multiple metabolic biotransformations in hepatocytes, including oxidation by cytochromes P450 (CYPs) and conjugation with taurine, glycine, glucuronic acid, and sulfate.
Botham, Buffie, C. Roland Wolf, Cen Xie, Chad N. Brocker, Cheng, Cheung, Colin J. Henderson, de Aguiar Vallim, Deo, Dragin, Fedorowski, Frank J. Gonzalez, Gonzalez, Greathouse, Gu, Hardison, Hasegawa, Hirano, Hofmann, Hofmann, Inagaki, Jiang, Jiang, Jones, Katagiri, Kristopher W. Krausz, Li, Löfgren, Matsubara, Mueller, Nelson, Russell, Russell, Sayin, Scheer, Scheer, Scheer, Scheer, Seeley, Shogo Takahashi, Tanaka, Tatsuki Fukami, Thomas, van Herwaarden, Yusuke Masuo   +45 more
core   +2 more sources

FARNESOID X RECEPTOR AND REPRODUCTION

Receptors & Clinical Investigation, 2015
Farnesoid X alpha receptors (FXRα or NR1H4) are present in male and female reproductive tissues. The aim of the present review is to describe those actions of the most relevant ligands of FXRα on reproduction and the interaction of this receptor with other nuclear receptors, for understanding the possible role of FXRα in reproductive events.
openaire   +1 more source

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic Fatty Liver Disease [PDF]

Endocrinology and Metabolism, 2016
Nonalcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver, occurring when fat is accumulated in the liver without alcohol consumption. NAFLD is the most common liver disorder in advanced countries.
Sun-Gi Kim, Byung-Kwon Kim, Kyumin Kim, Sungsoon Fang   +3 more
doaj   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding.

PLoS ONE, 2012
Farnesoid X receptor (FXR) is a nuclear receptor and a key regulator of liver cholesterol and triglyceride homeostasis. Scavenger receptor class B type I (SR-BI) is critical for reverse cholesterol transport (RCT) by transporting high-density lipoprotein
Guodong Li, Ann M Thomas, Jessica A Williams, Bo Kong, Jie Liu, Yuka Inaba, Wen Xie, Grace L Guo   +7 more
doaj   +1 more source

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]

, 2010
Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core   +1 more source

Managing non-alcoholic fatty liver disease in diabetes: challenges and opportunities [PDF]

, 2017
Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus are two common health problems worldwide. Globally, it has been estimated that a quarter of the adult population in the world currently suffers from NAFLD.1 In Asia, probably ...
Lam, KSL, Lee, CHP
core   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source