Results 101 to 110 of about 6,800,049 (185)

Role of gut microbiota in the development of non-alcoholic fatty liver disease

Liver Research, 2019
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by hepatic steatosis in the absence of other causes, such as chronic alcohol consumption, that cause secondary hepatic fat accumulation.
Xuemei Wang, Jialin Xia, Changtao Jiang
doaj   +1 more source

Gallstone formation and hepatobiliary tumour risk: Clinical implications of the bile acid–gut microbiota axis

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
1. Irregular dietary patterns (e.g., late breakfast, reduced meal frequency) upregulate the bai gene cluster by disrupting cholecystokinin (CCK) release rhythms and gut microbiota circadian rhythms, leading to increased production of secondary bile acids, particularly DCA. High‐carbohydrate dietary patterns increase gallstone risk (OR = 1.329).
Rui Li, Yong Zhang, Kaishuang Cai, Shaojun Deng, Chaofeng Tan, Yunjie Li, Wenjin Liang   +6 more
wiley   +1 more source

Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease

, 2020
Background: We previously showed that activation of the bile salt nuclear receptor Farnesoid X Receptor (FXR) protects against intestinal inflammation in mice. Reciprocally, these inflammatory mediators may decrease FXR activation.
Cisca Wijmenga, Rian M Nijmeijer, Saskia W C Van Mil, Gerard Dijkstra, Pieter C F Stokkers, Hein W Verspaget, Raffaella M Gadaleta, C Janneke Van Der Woude, A Crusius, Daan W Hommes, Janneke M Stapelbroek, Karel J Van Erpecum, Bas Oldenburg, Rinse K Weersma, Marguerite E I Schipper, Dirk J De Jong, Adriaan A Van Bodegraven, J Bart   +17 more
core  

Farnesoid X Receptor an Emerging Target to Combat Obesity

, 2017
Obesity and its associated diseases, including type 2 diabetes, have reached epidemic levels worldwide. However, available treatment options are limited and ineffective in managing the disease. There is therefore an urgent need for the development of new
C. Daniel De Magalhaes Filho, Ronald M. Evans, Michael Downes   +2 more
core   +1 more source

Farnesoid X Receptor Agonists: A Promising Therapeutic Strategy for Gastrointestinal Diseases

Gastro Hep Advances
Farnesoid X receptor (FXR) agonists have emerged as a promising therapeutic strategy for the management of various gastrointestinal (GI) diseases, including primary biliary cholangitis, nonalcoholic fatty liver disease, inflammatory bowel disease ...
Mohammad Almeqdadi, Fredric D. Gordon
doaj   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

The farnesoid X receptor and colon cancer

, 2016
Worldwide, colorectal cancer (CRC) is a leading cause of cancer death, primarily because of limited therapeutic options for those with advanced disease.
Raufman, Jean-Pierre, Xie, Guofeng
core  

The Bile Acid Signaling Axis: Deciphering the Roles of FXR and TGR5 in Hepatic Steatosis, Fibrosis, and Cancer

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Bile acids (BAs) serve not only as emulsifiers for lipid digestion but also as essential signaling molecules, governing various physiological and pathological processes through their interaction with the farnesoid X receptor (FXR) and the takeda G protein‐coupled receptor 5 (TGR5).
Jie Liu, Kui Sun, Hongmei Liu, Meiyang Zhu, Chunmeng Li, Yuqi He, Lin Qin   +6 more
wiley   +1 more source

Microbiota-induced obesity requires farnesoid X receptor

, 2017
OBJECTIVE: The gut microbiota has been implicated as an environmental factor that modulates obesity, and recent evidence suggests that microbiota-mediated changes in bile acid profiles and signalling through the bile acid nuclear receptor farnesoid X ...
Parseus, Ava,, Parséus, Ava, Bäckhed, Fredrik,, Ståhlman, Marcus,, Caesar, Robert,, Sommer, Nina, Caesar, Robert, Bäckhed, Gert Fredrik, Perkins, Rosie,, Sommer, Felix,, Molinaro, Antonio,, Sommer, Nina,, Ståhlman, Marcus, Perkins, Rosie, Sommer, Felix, Molinaro, Antonio, Greiner, Thomas U, Greiner, Thomas U.,   +17 more
core   +1 more source

Promoter DNA methylation of farnesoid X receptor and pregnane X receptor modulates the intrahepatic cholestasis of pregnancy phenotype.

PLoS ONE, 2014
The intrahepatic cholestasis of pregnancy (ICP) is a multifactorial liver disorder which pathogenesis involves the interplay among abnormal bile acid (BA) levels, sex hormones, environmental factors, and genetic susceptibility.
Romina Cabrerizo, Gustavo O Castaño, Adriana L Burgueño, Tomas Fernández Gianotti, María Mora Gonzalez Lopez Ledesma, Diego Flichman, Carlos J Pirola, Silvia Sookoian   +7 more
doaj   +1 more source