Results 121 to 130 of about 6,800,049 (185)

Targetting farnesoid-X-receptor: from medicinal chemistry to disease treatment.

, 2010
The farnesoid X receptor (FXRalpha) is a metabolic nuclear receptor and bile acid sensor expressed in the liver and intestine. Physiological studies have shown that FXRalpha exerts regulatory roles in bile acids, lipid and glucose homeostasis.
CIPRIANI, Sabrina, MENCARELLI, Andrea, FIORUCCI, Stefano, Palladino G, Distrutti E   +4 more
core  

Regulation of Tph cell differentiation via farnesoid X receptor of dendritic cells in inflammatory bowel disease. [PDF]

Inflamm Res
Hu Z, Liu M, Zhu C, Li N, Chen X, Da B, Li Y, Yu C.   +7 more
europepmc   +1 more source

Transcriptional regulation of ubiquitin specific peptidase 2b by farnesoid X receptor and its implications in the pathogenesis of hepatocellular carcinoma. [PDF]

Am J Cancer Res
Ali W, Nadolny C, Zhang X, Chen Q, Hashmi SF, Huniti T, Rahman MM, Bozza L, Warila D, Deng R.   +9 more
europepmc   +1 more source

DNA induces non-canonical dimerization of the farnesoid X receptor. [PDF]

Nucleic Acids Res
Khan SH, Yennawar N, Okafor CD.
europepmc   +1 more source

A Review on Farnesoid X Receptor (FXR) Modulators Focusing on Benzimidazole Scaffold. [PDF]

Molecules
Teno N, Gohda K, Fujimori K.
europepmc   +1 more source

Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70-Deficient Mice With a Human-Like Bile Acid Composition. [PDF]

Liver Int
de Vries HD, Li J, Ustyantsev K, Hovingh MV, Mulder NL, Havinga R, Palmiotti A, de Bruyn K, Attema B, Weersing E, Thomas RE, Bloks VW, Berezikov E, van Faassen M, Verkade HJ, de Boer JF, Kuipers F.   +16 more
europepmc   +1 more source

Correction: <i>Calculus Bovis Sativus</i> improves bile acid homeostasis via farnesoid X receptor-mediated signaling in rats with estrogen-induced cholestasis. [PDF]

Front Pharmacol
Xiang D, Yang J, Liu Y, He W, Zhang S, Li X, Zhang C, Liu D.   +7 more
europepmc   +1 more source

Activation of Brown Adipocytes by Farnesoid X Receptor Agonist, Obeticholic Acid-A Potential Novel Therapeutic Avenue in the Management of Obesity. [PDF]

J Clin Med
Dąbrowska AM, Chwil M, Urbańska EM.
europepmc   +1 more source

Obeticholic acid as an index farnesoid X receptor scaffold in metabolic dysfunction-associated steatohepatitis: a testable model for efficacy-liability separation and biomarker interpretation. [PDF]

Front Pharmacol
Liu J, Wu X.
europepmc   +1 more source

Comparison of serum Farnesoid X Receptor (FXR) levels and their associations with obesity-related metabolic parameters: a clinical study. [PDF]

BMC Endocr Disord
Yuksel Salduz ZI, Turgut R, Coskun ZS, Pasin O, Kartal M, Ozder A.   +5 more
europepmc   +1 more source