Results 141 to 150 of about 24,275 (247)

The bile salt export pump [PDF]

, 2018
Canalicular secretion of bile salts mediated by the bile salt export pump Bsep constitutes the major driving force for the generation of bile flow.
Meier, Peter, Meier, Yvonne, Stieger, Bruno   +2 more
core  

Gut Microbiota as a Mediator of Sarcopenic Obesity: Mechanisms, Modifiable Factors, and Healthcare Burden

Molecular Nutrition &Food Research, Volume 70, Issue 10, 27 May 2026.
Sarcopenic obesity is closely associated with gut microbiota dysbiosis, chronic inflammation, oxidative stress, and impaired muscle metabolism. The gut–muscle–adipose axis is increasingly recognized as a key mechanism linking obesity and sarcopenia. Nutritional strategies, probiotics, prebiotics, postbiotics, and exercise may modulate gut microbiota ...
Mehtap Ünlü Söğüt, Merve Ahıskalı, Mina Mohammadzadeh, Menşure Nur Çelik, Nurcan Coşkun Us   +4 more
wiley   +1 more source

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source

Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.
Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg, Jesus M. Banales, Gideon Hirschfield, Palak Trivedi, Edward E. Cable, Charles A. McWherter, Andrew N. Billin, Daria B. Crittenden, Grant Budas   +8 more
wiley   +1 more source

High cholesterol absorption efficiency interferes with bile acid metabolism and cholesterol elimination from the body

Journal of Internal Medicine, Volume 299, Issue 5, Page 628-638, May 2026.
Abstract Background Elevated low‐density lipoprotein (LDL) cholesterol causes atherosclerotic cardiovascular diseases. Variables of whole‐body cholesterol metabolism, for example, high cholesterol absorption efficiency, might also be atherogenic, whereas the role of bile acids is controversial.
Piia Simonen, Ingmar Wester, Jyri Lommi, Juha Sinisalo, Helena Gylling   +4 more
wiley   +1 more source

Vitamin D to reduce liver fibrosis in non-alcoholic fatty liver disease [PDF]

, 2017
BACKGROUND: As the prevalence of metabolic risk factors in the American population has increased over time, so too has the diagnoses of non-alcoholic fatty liver disease (NAFLD).
Fox, Ryan
core  

DNA induces non-canonical dimerization of the farnesoid X receptor. [PDF]

Nucleic Acids Res
Khan SH, Yennawar N, Okafor CD.
europepmc   +1 more source

A Review on Farnesoid X Receptor (FXR) Modulators Focusing on Benzimidazole Scaffold. [PDF]

Molecules
Teno N, Gohda K, Fujimori K.
europepmc   +1 more source

Intracellular cholesterol transporters and modulation of hepatic lipid metabolism: implications for diabetic dyslipidaemia and steatosis [PDF]

, 2014
Caridis, Anna-Maria, Dolan, Sharron, Graham, Annette, Soffientini, Ugo   +3 more
core   +1 more source

Estradiol, farnesoid X receptor, and altered metabolism in pregnancy [PDF]

Hepatology, 2014
Shadi, Abu-Hayyeh, Catherine, Williamson
openaire   +2 more sources