Results 161 to 170 of about 6,800,049 (185)

Inhibition of Farnesoid-x-receptor signaling during abdominal sepsis by dysbiosis exacerbates gut barrier dysfunction. [PDF]

Cell Commun Signal
Qian S, Su Z, Lin J, Hou Q, Wang X, Li Y, Wang J, Huang C, Wang Z, Cubero FJ, Wang X, Liao L.   +11 more
europepmc   +1 more source

Farnesoid X Receptor Attenuates the Tumorigenicity of Liver Cancer Stem Cells by Inhibiting STAT3 Phosphorylation. [PDF]

Int J Mol Sci
Ye W, Zhao Y, Wang Y, Wang Y, Zhang H, Wang F, Chen W.   +6 more
europepmc   +1 more source

The mood stabilizers lithium and valproate disrupt hepatic and intestinal farnesoid X receptor signalling and increase bile synthesis in the rat. [PDF]

Exp Physiol
Cussotto S, Golubeva AV, Gallardo AL, Bastiaanssen TFS, Zhdanov AV, Moloney GM, Scaife C, English JA, Joyce SA, Dinan TG, Cryan JF.   +10 more
europepmc   +1 more source

Crosstalk Between Bile Acids and Intestinal Epithelium: Multidimensional Roles of Farnesoid X Receptor and Takeda G Protein Receptor 5. [PDF]

Int J Mol Sci
Lin X, Xia L, Zhou Y, Xie J, Tuo Q, Lin L, Liao D.   +6 more
europepmc   +1 more source

Pig bile powder maintains blood glucose homeostasis by promoting glucagon-like peptide-1 secretion <i>via</i> inhibiting farnesoid X receptor. [PDF]

World J Diabetes
Sun YM, Kuang JL, Zhang HH, Xia XX, Wang JY, Zheng D, Zhou KJ, Tang YJ, Zhao AH, Jia W, Xie GX, Zheng XJ.   +11 more
europepmc   +1 more source

Efficacy, Safety, and Tolerability of Farnesoid X Receptor Agonists in the Treatment of Metabolic Dysfunction-associated Steatotic Liver Disease: A Systematic Review and Meta-analysis. [PDF]

J Clin Exp Hepatol
Mekontso JGK, Nnang JYB, Tembi TBT, Kortim AB, Nguefang GL, Wagner J, Bernstein M.   +6 more
europepmc   +1 more source

The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity [PDF]

International Journal of Molecular Sciences, 2022
The nuclear receptor farnesoid X receptor (FXR, NR1H4) is a bile acid (BA) sensor that links the enterohepatic circuit that regulates BA metabolism and elimination to systemic lipid homeostasis.
Michele Visentin, Gerd A Kullak-Ublick, Sophia L Samodelov   +2 more
exaly   +3 more sources

Farnesoid X receptor modulators (2011 – 2014): a patent review

Expert Opinion on Therapeutic Patents, 2015
Farnesoid-X-receptor (FXR) is the receptor for primary bile acids expressed in enterohepatic tissues where it regulates bile acid uptake, metabolism and disposal.
Valentina Sepe, Angela Zampella, Stefano Fiorucci   +2 more
exaly   +2 more sources

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The identification of farnesoid X receptor modulators as treatment options for nonalcoholic fatty liver disease

Expert Opinion on Drug Discovery, 2021
Valentina Sepe, Michele Biagioli, Monia Baldoni   +2 more
exaly  

Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis

Cell Metabolism, 2017
Shogo Takahashi, Changtao Jiang, Frank J. Gonzalez   +2 more
exaly