Results 11 to 20 of about 6,800,049 (185)

The Farnesoid X Receptor: Good for BADSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2016
Diarrhea is a feature of several chronic intestinal disorders that are associated with increased delivery of bile acids into the colon. Although the prevalence of bile acid diarrhea is high, affecting approximately 1% of the adult population, current ...
Stephen J. Keely, Julian R.F. Walters
doaj   +2 more sources

Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA

Computational and Structural Biotechnology Journal, 2023
Farnesoid X receptor (FXR) is a ligand-activated transcription factor known as bile acid receptor (BAR). FXR plays critical roles in various biological processes, including metabolism, immune inflammation, liver regeneration and liver carcinogenesis. FXR
Longying Jiang, Xueke Liu, Xujun Liang, Shuyan Dai, Hudie Wei, Ming Guo, Zhuchu Chen, Desheng Xiao, Yongheng Chen   +8 more
doaj   +2 more sources

Probucol ameliorates hepatic stellate cell activation and autophagy is associated with farnesoid X receptor

Journal of Pharmacological Sciences, 2019
Probucol has antioxidant effects and inhibits inflammation. Farnesoid X receptor (FXR) is a nuclear receptor that regulates autophagy, which is regarded as the key cause of the activation of hepatic stellate cell (HSC).
Ruhui Yang, Zhiyong Hu, Pengyong Zhang, Songquan Wu, Zhaoxia Song, Xiangchun Shen, Zhe Wei   +6 more
doaj   +2 more sources

Primary Biliary Cholangitis and Bile Acid Farnesoid X Receptor Agonists

Diseases, 2020
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by the progressive destruction of the intrahepatic bile ducts. Currently, the first line drug for PBC is ursodeoxycholic acid (UDCA) characterized by anti-apoptotic ...
Ludovico Abenavoli, Anna Caterina Procopio, Sharmila Fagoonee, Rinaldo Pellicano, Marco Carbone, Francesco Luzza, Pietro Invernizzi   +6 more
doaj   +2 more sources

Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists

Molecules, 2023
Compounds featuring a 1,2,4-oxadiazole core have been recently identified as a new chemotype of farnesoid X receptor (FXR) antagonists. With the aim to expand this class of compounds and to understand the building blocks necessary to maintain the ...
Claudia Finamore, Carmen Festa, Bianca Fiorillo, Francesco Saverio Di Leva, Rosalinda Roselli, Silvia Marchianò, Michele Biagioli, Lucio Spinelli, Stefano Fiorucci, Vittorio Limongelli, Angela Zampella, Simona De Marino   +11 more
doaj   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]

, 2010
This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Albert K. Groen, Hageman, Jurre, Herrema, H.J., Folkert Kuipers, Hageman, J., Kuipers, Folkert, Herrema, Hilde, Hilde Herrema, Kuipers, Folkert; id_orcid, Groen, A.K., Kuipers, F., Groen, Albert K., Jurre Hageman   +12 more
core   +1 more source

Stimulation of the farnesoid X receptor promotes M2 macrophage polarization

Frontiers in Immunology, 2023
FXR is a key molecule that modulates anti-inflammatory activity in the intestinal-liver axis. Although FXR has pleiotropic functions including regulation of liver inflammation and activation of macrophages, it remains unclear whether it is involved in ...
Thiranut Jaroonwitchawan, Hideki Arimochi, Yuki Sasaki, Chieko Ishifune, Hiroyuki Kondo, Kunihiro Otsuka, Kunihiro Otsuka, Shin-ichi Tsukumo, Shin-ichi Tsukumo, Koji Yasutomo, Koji Yasutomo, Koji Yasutomo   +11 more
doaj   +1 more source

Intestinal Sirtuin 1 Controls Liver Regeneration via Regulating the Intestinal Farnesoid X Receptor/Fibroblast Growth Factor 15 Axis in Mice. [PDF]

Cell Mol Gastroenterol Hepatol
Background & Aims: The contribution of the gut–liver axis during liver regeneration remains poorly understood. Understanding the mechanisms underlying this process is critical for developing novel therapeutic strategies for liver diseases and ...
Seaman S, Ruiz P, Nirello VD, Martin-Castilla L, Elizalde-Garcia P, Vega-Zuza A, Vegas-Petrina L, Lumbreras-Perales C, Philo M, Moreno-Gonzalez M, Varga-Weisz P, Beraza N.   +11 more
europepmc   +2 more sources

Farnesoid X receptor represses hepatic lipase gene expression

Journal of Lipid Research, 2004
The farnesoid X receptor (FXR) is a nuclear receptor that regulates gene expression in response to bile acids (BAs). FXR plays a central role in BA, cholesterol, and lipoprotein metabolism.
Audrey Sirvent, Adrie J.M. Verhoeven, Hans Jansen, Vladimir Kosykh, Raphaël J. Darteil, Dean W. Hum, Jean-Charles Fruchart, Bart Staels   +7 more
doaj   +1 more source