Results 11 to 20 of about 789,953 (305)
Journal of Integrative Neuroscience, 2021 The disorder of lipid metabolism, especially cholesterol metabolism, can promote Alzheimer’s Disease. Curcumin can ameliorate lipid metabolic disorder in the brain of Alzheimer’s Disease patients, while the mechanism is not clear.
Mingyuan Tian +6 more
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Liver X receptor in cholesterol metabolism [PDF]
Journal of Endocrinology, 2009 The liver X receptors (LXRs) are nuclear receptors that are activated by endogenous oxysterols, oxidized derivatives of cholesterol. There are two isoforms of LXR, LXRα (NR1H3) and LXRβ (NR1H2). Both LXRα and LXRβ regulate gene expression by binding to DNA sequences associated with target genes as heterodimers with isoforms of the retinoid X receptor ...
Chunyan, Zhao, Karin, Dahlman-Wright
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LXRs: The Key Regulators of Intermediary Metabolism in Metabolic Syndrome [PDF]
Reviews in Clinical Medicine, 2017 Metabolic syndrome and its various manifestations are considered to be a significant health epidemic in the developed and developing countries across the world.
Hassan Mehrad-Majd +2 more
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Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. [PDF]
, 2008 The liver is responsible for key metabolic functions, including control of normal homoeostasis in response to diet and xenobiotic metabolism/detoxification.
Finn, Robert +3 more
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Inflammation Triggers Liver X Receptor-Dependent Lipogenesis [PDF]
Molecular and Cellular Biology, 2020 Immune cell function can be modulated by changes in lipid metabolism. Our studies indicate that cholesterol and fatty acid synthesis increases in macrophages between 12 and 18 h after the activation of Toll-like receptors with proinflammatory stimuli and that the upregulation of lipogenesis may contribute to the resolution of inflammation.
Sophie R. Liebergall +7 more
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Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy [PDF]
, 1992 The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and ...
Eisenmenger, Wolfgang +5 more
core +1 more source
Journal of Lipid Research, 2013 Long-chain acyl-CoA synthetases (ACSL) play key roles in fatty acid metabolism in liver and other metabolic tissues in an isozyme-specific manner. In this study, we examined the effects of a fructose-enriched diet on expressions of ACSL isoforms in the ...
Bin Dong +3 more
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The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury. [PDF]
, 2010 The pregnane X receptor (PXR) is a nuclear receptor transcription factor regulating drug-metabolizing enzymes and transporters that facilitate xenobiotic and endobiotic detoxification.
Damjanov, Ivan +2 more
core +2 more sources
Phosphorylation of the liver X receptors [PDF]
FEBS Letters, 2006 The liver X receptors (LXRs) function as nutritional sensors for cholesterol and have important roles in lipid metabolism, glucose homeostasis, and inflammation. We provide the first evidence that LXRs are phosphorylated proteins. Mutational analysis and metabolic labeling indicate LXRα is phosphorylated on serine 198 in the hinge region.
Chen, Mingyi +3 more
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Journal of Pharmacological Sciences, 2005 Nuclear receptors are ligand-dependent transcription factors that recently have been shown to play important roles in the metabolism of cholesterol and bile acids.
Makoto Makishima
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