Natural Products Targeting Liver X Receptors or Farnesoid X Receptor [PDF]
Frontiers in Pharmacology, 2022 Nuclear receptors (NRs) are a superfamily of transcription factors induced by ligands and also function as integrators of hormonal and nutritional signals.
Jianglian She +9 more
doaj +5 more sources
Ligands of Therapeutic Utility for the Liver X Receptors [PDF]
Molecules, 2017 Liver X receptors (LXRs) have been increasingly recognized as a potential therapeutic target to treat pathological conditions ranging from vascular and metabolic diseases, neurological degeneration, to cancers that are driven by lipid metabolism.
Rajesh Komati +5 more
doaj +5 more sources
Targeting Liver X Receptors for the Treatment of Non-Alcoholic Fatty Liver Disease [PDF]
Cells, 2023 Non-alcoholic fatty liver disease (NAFLD) refers to a range of conditions in which excess lipids accumulate in the liver, possibly leading to serious hepatic manifestations such as steatohepatitis, fibrosis/cirrhosis and cancer.
Hyejin Kim, Chaewon Park, Tae Hyun Kim
doaj +2 more sources
Liver X receptors induce antiproliferative effects in basal‐like breast cancer [PDF]
Molecular Oncology, 2023 Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The antiproliferative role of LXRs has been studied in a variety of malignancies and may represent a ...
Mads Haugland Haugen +14 more
doaj +2 more sources
Activation of liver X receptors protects oligodendrocytes in CA3 of stress-induced mice [PDF]
Frontiers in Pharmacology, 2022 Depression is a complex disorder that is associated with various structural abnormalities. Oligodendrocyte (OL) dysfunction is associated with the pathogenesis of depression and the promotion of hippocampal oligodendrocyte maturation and myelination ...
Peilin Zhu +30 more
doaj +2 more sources
Liver X Receptors: Regulators of Cholesterol Metabolism, Inflammation, Autoimmunity, and Cancer [PDF]
Frontiers in Immunology, 2020 The interplay between cellular stress and immune response can be variable and sometimes contradictory. The mechanisms by which stress-activated pathways regulate the inflammatory response to a pathogen, in autoimmunity or during cancer progression remain
Maria Teresa Bilotta +5 more
doaj +2 more sources
Pseudorabies Virus Inhibits Expression of Liver X Receptors to Assist Viral Infection [PDF]
Viruses, 2022 Pseudorabies virus (PRV) is a contagious herpesvirus that causes Aujeszky’s disease and economic losses worldwide. Liver X receptors (LXRs) belong to the nuclear receptor superfamily and are critical for the control of lipid homeostasis.
Yi Wang +11 more
doaj +2 more sources
Disrupted Lipid Metabolism in Multiple Sclerosis: A Role for Liver X Receptors? [PDF]
Frontiers in Endocrinology, 2021 Multiple sclerosis (MS) is a chronic neurological disease driven by autoimmune, inflammatory and neurodegenerative processes leading to neuronal demyelination and subsequent degeneration.
Inés Pineda-Torra +5 more
doaj +2 more sources
Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs) [PDF]
Scientific Reports, 2021 The interactions of derivatives of lumisterol (L3) and vitamin D3 (D3) with liver X receptors (LXRs) were investigated. Molecular docking using crystal structures of the ligand binding domains (LBDs) of LXRα and β revealed high docking scores for L3 and ...
Andrzej T. Slominski +18 more
doaj +2 more sources
Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice. [PDF]
Immun Inflamm Dis, 2016 Introduction: Liver X receptors (LXRs) are nuclear receptors that function as cholesterol sensors and regulate cholesterol homeostasis. High cholesterol has been recognized as a risk factor in asthma; however, the mechanism of this linkage is not known.
Smet M +10 more
europepmc +3 more sources