Results 11 to 20 of about 524,130 (286)
Liver X receptors and liver physiology [PDF]
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2021 The liver x receptors LXRα (NR1H3) and LXRβ (NR1H2) are members of the nuclear hormone receptor superfamily of ligand dependent transcription factors that regulate transcription in response to the direct binding of cholesterol derivatives. Studies using genetic knockouts and synthetic ligands have defined the LXRs as important modulators of lipid ...
Ira G Schulman
exaly +4 more sources
Liver X receptors as regulators of metabolism
Biomolecular Concepts, 2015 The liver X receptors (LXR) are crucial regulators of metabolism. After ligand binding, they regulate gene transcription and thereby mediate changes in metabolic pathways.
Korach-André Marion +1 more
doaj +3 more sources
Liver X receptors and immune regulation
Biomolecular Concepts, 2010 Recent studies suggest that homeostasis of lipid metabolism is crucial for the function of various immune cells. Oxygenated derivatives of cholesterol (oxysterols) are well-known regulators of lipid metabolism and have diverse functions, such as ...
Nunomura Satoshi +2 more
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Liver X receptors: A therapeutic target in demyelinating disorders
Pharmacological ResearchLiver X Receptors (LXRα and LXRβ) are nuclear receptors that regulate various metabolic processes via transcriptional regulation, including lipid and cholesterol homeostasis.
Jule Richartz +7 more
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Liver X Receptors and Inflammatory-Induced C/EBPβ Selectively Cooperate to Control CD38 Transcription [PDF]
Journal of Innate ImmunityIntroduction: Macrophages abundantly express liver X receptors (LXRs), which are ligand-dependent transcription factors and sensors of several cholesterol metabolites.
Estibaliz Glaría +11 more
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Liver X receptors activation, through TO901317 binding, reduces neuroinflammation in Parkinson's disease. [PDF]
PLoS ONE, 2017 Parkinson's disease (PD) is a neurodegenerative disease in which degeneration of nigrostriatal neurons and inflammation are key players. The aim of our study was to analyze the function of LXRs in neurodegenerative diseases as PD using in vivo, ex vivo ...
Irene Paterniti +8 more
doaj +2 more sources
Liver X receptors are required for thymic resilience and T cell output [PDF]
Journal of Experimental Medicine, 2020 Christopher T Chan +2 more
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Liver X Receptors and Male (In)fertility. [PDF]
Int J Mol Sci, 2019 Liver X receptors (LXRs) are ligand-dependent transcription factors acting as ‘cholesterol sensors’ to regulate lipid homeostasis in cells. The two isoforms, LXRα (NR1H3) and LXRβ (NR1H2), are differentially expressed, with the former expressed predominantly in metabolically active tissues and the latter more ubiquitously.
Jarvis S, Williamson C, Bevan CL.
europepmc +5 more sources
Cellular and Molecular Gastroenterology and Hepatology, 2021 Nonalcoholic fatty liver disease comprises a wide spectrum of liver injuries from simple steatosis to steatohepatitis and cirrhosis. Nonalcoholic steatohepatitis (NASH) is defined when liver steatosis is associated with inflammation, hepatocyte damage ...
Marica Cariello +2 more
doaj +1 more source
Loss of the Liver X Receptors Disrupts the Balance of Hematopoietic Populations, With Detrimental Effects on Endothelial Progenitor Cells [PDF]
Journal of the American Heart Association, 2018 Carolyn L Cummins
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