Results 81 to 90 of about 15,927 (179)

Aedes cadherin receptor that mediates Bacillus thuringiensis Cry11A toxicity is essential for mosquito development. [PDF]

, 2020
Aedes cadherin (AaeCad, AAEL024535) has been characterized as a receptor for Bacillus thuringiensis subsp. israelensis (Bti) Cry11A toxins. However, its role in development is still unknown.
Aimanova, Karly G, Chen, Jianwu, Gill, Sarjeet S   +2 more
core   +2 more sources

Disrupted lipid homeostasis as a pathogenic mechanism in ABCA7‐associated Alzheimer's disease risk

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION ABCA7 (ATP binding cassette subfamily A member 7) encodes a lipid transporter associated with increasing risk for Alzheimer's disease (AD). A 44‐base pair deletion in ABCA7 (rs142076058; p.Arg578Alafs) is a strong risk factor in individuals of African ancestry (AA).
Younji Nam, Brooke A. DeRosa, Aura M. Ramirez, Biniyam A. Ayele, Patrice Whitehead‐Gay, Larry D. Adams, Charles G. Golightly, Takiyah D. Starks, Mayra Juliana Laverde‐Paz, Holly N. Cukier, Rufus Akinyemi, Fred Sarfo, Albert Akpalu, Michael L. Cuccaro, Scott M. Williams, Allison Caban‐Holt, Christiane Reitz, Jonathan L. Haines, Goldie S. Byrd, Farid Rajabli, Derek M. Dykxhoorn, Juan I. Young, Jeffery M. Vance, Margaret A. Pericak‐Vance   +23 more
wiley   +1 more source

Обратный транспорт холестерина из макрофагов [PDF]

, 2011
МАКРОФАГИХОЛЕСТЕРИ
Куликов, В. А.
core  

Deciphering the Chemotherapeutic Mechanism of Ferulic Acid: Insight Into the Role Against Multiple Human Cancers

Cancer Innovation, Volume 5, Issue 2, April 2026.
Ferulic acid (FA), a naturally occurring compound, exhibits anticancer activity against 16 cancer types through multiple molecular pathways. Its enhanced delivery via nanoformulations and synergistic effects with other therapies suggest FA as a promising, food‐based adjunct for cancer symptom control until fully approved pharmaceutical options are ...
Sanzida Khatun, Md Sohel, Zitu Barman, Umme Salma, Lubatul Arbia, Md. Rifat Sarker, Jasmin Akter Jame, Badhan Rani Dey, Sultana Parvin, Md. Shah Poran Shuvo, Md. Shahidul Islam, Tania Mannan, Snygdha Rani Das, Md. Mahmudul Hasan   +13 more
wiley   +1 more source

Targeting ABCG1 and SREBP-2 mediated cholesterol homeostasis ameliorates Zika virus-induced ocular pathology

iScience
Summary: Zika virus (ZIKV) infection during pregnancy causes severe neurological and ocular abnormalities in infants, yet no vaccine or antivirals are available. Our transcriptomic analysis of ZIKV-infected retinal pigment epithelial (RPE) cells revealed
Sneha Singh, Robert E. Wright, III, Shailendra Giri, Vaithilingaraja Arumugaswami, Ashok Kumar   +4 more
doaj   +1 more source

Potential Effects of Aspirin on Transcription Factors Related to the Inflammation in Atherosclerosis: A Systematic Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Atherosclerosis (AS), a major cause of cardiovascular mortality, involves chronic inflammation mediated by transcription factors such as NF‐κB, PPARs, and AP‐2α. Beyond its antiplatelet role, aspirin exerts anti‐inflammatory effects that may influence these molecular pathways.
Mojtaba Aghaei, Reyhane Khademi, Seyed Sobhan Bahreiny, Habib Haybar, Ekhlas Torfi, Shirin Azizidoost, Najmaldin Saki   +6 more
wiley   +1 more source

Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Pparγ/Lxrα Signaling Pathway-Dependent Manner

Cellular Physiology and Biochemistry, 2017
Background/Aims: Previous studies have demonstrated that leonurine, a unique alkaloid compound of Herba leonuri, can exert anti-oxidative and anti-inflammatory effects on the development of atherosclerosis (AS). This study was designed to investigate the
Ting Jiang, Kun Ren, Qian Chen, Heng Li, Rong Yao, Hu Hu, Yun-Cheng Lv, Guo-Jun Zhao   +7 more
doaj   +1 more source

ABCG1 Attenuates Oxidative Stress Induced by H2O2 through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells

Analytical Cellular Pathology, 2020
Summary. Oxidative stress is an important factor that is related to endothelial dysfunction. ATP-binding cassette transporter G1 (ABCG1), a regulator of intracellular cholesterol efflux, has been found to prevent endothelial activation in vessel walls ...
Jiahong Xue, Jiali Fan, Yuan Li, Wenhuan Wu, Qing Yan, Qiangsun Zheng   +5 more
doaj   +1 more source

In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System [PDF]

, 2016
Accurate prediction of the potential hepatotoxic nature of new pharmaceuticals remains highly challenging. Therefore, novel in vitro models with improved external validity are needed to investigate hepatic metabolism and timely identify any toxicity ...
Damm, Georg, De Bondt, An, Freyer, Nora, Jacobs, Frank, Knöspel, Fanny, Monshouwer, Mario, Richter, Marco, Seehofer, Daniel, Snoeys, Jan, Strahl, Nadja, Wyngaert, Ilse van den, Zeilinger, Katrin   +11 more
core   +2 more sources

Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1

Lipids in Health and Disease, 2009
Background Cognitive deficits are a hallmark feature of both Down Syndrome (DS) and Alzheimer's Disease (AD). Extra copies of the genes on chromosome 21 may also play an important role in the accelerated onset of AD in DS individuals.
Eadie Brennan D, Kannangara Timal S, Parkinson Pamela F, Burgess Braydon L, Wellington Cheryl L, Christie Brian R   +5 more
doaj   +1 more source