Results 81 to 90 of about 1,912,571 (214)

DPP-4 Inhibitor Linagliptin Ameliorates Oxidized LDL-Induced THP-1 Macrophage Foam Cell Formation and Inflammation

Drug Design, Development and Therapy, 2020
Haoran Wang,1 Yue Li,2 Xiaoliang Zhang,2 Zhonglin Xu,2 Jianzhong Zhou,3 Wei Shang2 1Department of Endocrinology, The Ninth People’s Hospital of Chongqing, Chongqing 400700, People’s Republic of China; 2Department of Cardiology, The Ninth ...
Wang H, Li Y, Zhang X, Xu Z, Zhou J, Shang W   +5 more
doaj  

The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver

Journal of Lipid Research, 2005
The ABC transporter ABCG1 (ATP binding cassette transporter G1), expressed in macrophages, liver, and other tissues, has been implicated in the efflux of cholesterol to high density lipoprotein.
Steven L. Sabol, H. Bryan Brewer, Jr., Silvia Santamarina-Fojo   +2 more
doaj   +1 more source

Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher, Fiona L. Motel, Felix F. Lillich, Astrid Kaiser, Ewgenij Proschak, Pascal Heitel   +5 more
wiley   +1 more source

High Density Lipoproteins Inhibit Oxidative Stress-Induced Prostate Cancer Cell Proliferation

Scientific Reports, 2018
Recent evidence suggests that oxidative stress can play a role in the pathogenesis and the progression of prostate cancer (PCa). Reactive oxygen species (ROS) generation is higher in PCa cells compared to normal prostate epithelial cells and this ...
Massimiliano Ruscica, Margherita Botta, Nicola Ferri, Eleonora Giorgio, Chiara Macchi, Guido Franceschini, Paolo Magni, Laura Calabresi, Monica Gomaraschi   +8 more
doaj   +1 more source

Postprandial lipemia enhances the capacity of large HDL2 particles to mediate free cholesterol efflux via SR-BI and ABCG1 pathways in type IIB hyperlipidemia[S]

Journal of Lipid Research, 2010
Lipid and cholesterol metabolism in the postprandial phase is associated with both quantitative and qualitative remodeling of HDL particle subspecies that may influence their anti-atherogenic functions in the reverse cholesterol transport pathway.
Zélie Julia, Emilie Duchene, Natalie Fournier, Natacha Bellanger, M. John Chapman, Wilfried Le Goff, Maryse Guerin   +6 more
doaj   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, Volume 13, Issue 56, 9 October 2026.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Associations of plasma HDL subclasses with incident dementia risk in older adults

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Plasma high‐density lipoprotein (HDL) varies in size. We examined the associations between HDL subclasses and their lipid composition and incident dementia risk in older adults. METHODS We included 23,790 United Kingdom (UK) Biobank (UKB) and 147 Atherosclerosis Risk in Communities (ARIC) older adults free of dementia at baseline.
Binchong An, Suad Ali, Karen Smith, Samantha Roemhild, Lindsey Neumann, Dwight R. Stoll, Ling Li, Pamela L Lutsey, Michelle M Mielke, Fang Yu, Ron C Hoogeveen, Lin Zhang, Alvaro Alonso, Danni Li   +13 more
wiley   +1 more source

Funktionelle Rekonstitution des menschlichen lysosomale Peptid-Transporter TAPL zeigt die Substratspezifität [PDF]

, 2009
The transporter associated with antigen processing-like (TAPL) acts as a lysosomal ATP-dependent polypeptide transporter with broad length selectivity. To characterize in detail its substrate specificity, a procedure for solubilization, purification and ...
Zhao, Chenguang
core  

Structural and functional fingerprint of the mitochondrial ATP-binding cassette transporter Md11 from Saccharomyces cerevisiae

, 2006
The ATP-binding cassette half-transporter Mdl1 from Saccharomyces cerevisiae has been proposed to be involved in the quality control of misassembled respiratory chain complexes by exporting degradation products generated by the m-AAA proteases from the ...
Hofacker, Matthias, Zutz, A., Tampé, Robert, Gompf, S, Model, K., Presenti, C., Haase, W., Zutz, Ariane, K. Model, Presenti, C, R. Tampe, Model, K, Tampé, R., C. van der Does, Hofacker, M, S. Gompf, Gompf, Simone, van der Does, C., M. Hofacker, Tampé, R, Haase, W, A. Zutz, W. Haase, Haase, Winfried, Model, Kirstin, Hofacker, M., Presenti, Chiara, Zutz, A, Gompf, S., C. Presenti, Does, Chris van der   +30 more
core   +2 more sources