Results 91 to 100 of about 1,912,571 (214)

Targeting ABCG1 and SREBP-2 mediated cholesterol homeostasis ameliorates Zika virus-induced ocular pathology

iScience
Summary: Zika virus (ZIKV) infection during pregnancy causes severe neurological and ocular abnormalities in infants, yet no vaccine or antivirals are available. Our transcriptomic analysis of ZIKV-infected retinal pigment epithelial (RPE) cells revealed
Sneha Singh, Robert E. Wright, III, Shailendra Giri, Vaithilingaraja Arumugaswami, Ashok Kumar   +4 more
doaj   +1 more source

Thiolated Alginate for Mucoadhesive and Redox‐Responsive Drug Delivery: Chemistry, Structure‐Function Relationships and Translational Development

Applied Research, Volume 5, Issue 5, October 2026.
Thiol and disulfide modifications can help alginate carriers adhere to mucus and release drugs in response to reducing environments. This review links modification chemistry to delivery performance and highlights reproducible manufacturing, stability, and safety validation as priorities for clinical translation.
Parteek Prasher, Mousmee Sharma, Rabab Fatima, Shraddha Chugh, Harish Mudila, Flavia Zacconi, Javad Sharifi‐Rad, Daniela Calina, William N. Setzer   +8 more
wiley   +1 more source

Maltose-binding protein effectively stabilizes the partially closed conformation of the ATP-binding cassette transporter MalFGK2

, 2017
Maltose transporter MalFGK2is a type-I importer in the ATP-binding cassette (ABC) transporter superfamily.
Gao, Xin, Huang, Xuhui, Xuhui Huang, Wenning Wang, Wang, Wenning, Weng, Jingwei, Jingwei Weng, Xin Gao, Gu, Shuo, Shuo Gu   +9 more
core   +1 more source

Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Pparγ/Lxrα Signaling Pathway-Dependent Manner

Cellular Physiology and Biochemistry, 2017
Background/Aims: Previous studies have demonstrated that leonurine, a unique alkaloid compound of Herba leonuri, can exert anti-oxidative and anti-inflammatory effects on the development of atherosclerosis (AS). This study was designed to investigate the
Ting Jiang, Kun Ren, Qian Chen, Heng Li, Rong Yao, Hu Hu, Yun-Cheng Lv, Guo-Jun Zhao   +7 more
doaj   +1 more source

ABCG1 Attenuates Oxidative Stress Induced by H2O2 through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells

Analytical Cellular Pathology, 2020
Summary. Oxidative stress is an important factor that is related to endothelial dysfunction. ATP-binding cassette transporter G1 (ABCG1), a regulator of intracellular cholesterol efflux, has been found to prevent endothelial activation in vessel walls ...
Jiahong Xue, Jiali Fan, Yuan Li, Wenhuan Wu, Qing Yan, Qiangsun Zheng   +5 more
doaj   +1 more source

Supplementary Data from Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters

, 2009
Supplementary Data from Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette ...
Michelle A. Rudek (670366), Shuiying Hu (10268480), Ming Zhao (48501), Ryan Franke (14975605), Shelley Orwick (8371137), Alex Sparreboom (236030), Zhaoyuan Chen (11130801), Sharyn D. Baker (14918718)   +7 more
core   +1 more source

Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1

Lipids in Health and Disease, 2009
Background Cognitive deficits are a hallmark feature of both Down Syndrome (DS) and Alzheimer's Disease (AD). Extra copies of the genes on chromosome 21 may also play an important role in the accelerated onset of AD in DS individuals.
Eadie Brennan D, Kannangara Timal S, Parkinson Pamela F, Burgess Braydon L, Wellington Cheryl L, Christie Brian R   +5 more
doaj   +1 more source

Biochemical Characterization of ATP-Binding Cassette Transporter G1 Mediated Cholesterol Efflux

, 2012
ABCG1 mediates cholesterol efflux onto lipidated apolipoprotein A-I and plays an important role in macrophage reverse cholesterol transport, thereby preventing atherosclerosis. However, how ABCG1 mediates cholesterol efflux is unclear. We found that Cys514 located within the third putative transmembrane domain is highly conserved. Replacement of Cys514
openaire   +1 more source

ATP binding cassette G1-dependent cholesterol efflux during inflammation1

Journal of Lipid Research, 2011
ATP binding cassette transporter G1 (ABCG1) mediates the transport of cellular cholesterol to HDL, and it plays a key role in maintaining macrophage cholesterol homeostasis.
Maria C. de Beer, Ailing Ji, Anisa Jahangiri, Ashley M. Vaughan, Frederick C. de Beer, Deneys R. van der Westhuyzen, Nancy R. Webb   +6 more
doaj   +1 more source

ABCB5 and the regulation of p16INK4a by non-coding RNA [PDF]

, 2014
p16INK4a (p16) traps the cell at the restriction point of the cell cycle by binding to cyclin-dependent kinase 4/6 thus preventing the phosphorylation of the retinoblastoma protein (pRB).
Braker, Paul
core   +1 more source