Retardation of atherosclerosis in immunocompetent apolipoprotein (apo) E-deficient mice followingliver-directed administration of a [E1-, E3-,polymerase-] adenovirus vector containing the elongation factor-1a promoter driving expression of human apoE cDNA [PDF]
, 2005 Although gene transfer of human apolipoprotein E (apoE), a 34-kDa circulating glycoprotein, to the liver of apoEdeficient(apoE-/-) mice using recombinant adenoviral vectors (rAd) is antiatherogenic, its full therapeutic potentialhas yet to be realized ...
Amalfitano, A +6 more
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ATP binding cassette G1-dependent cholesterol efflux during inflammation1
Journal of Lipid Research, 2011 ATP binding cassette transporter G1 (ABCG1) mediates the transport of cellular cholesterol to HDL, and it plays a key role in maintaining macrophage cholesterol homeostasis.
Maria C. de Beer +6 more
doaj +1 more source
Toxins, 2015 One of the possible causes of enhanced atherosclerosis in patients with chronic kidney disease (CKD) is the accumulation of uremic toxins. Since macrophage foam cell formation is a hallmark of atherosclerosis, we examined the direct effect of indoxyl ...
Koji Matsuo +8 more
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miRNAs link metabolic reprogramming to oncogenesis [PDF]
, 2013 The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M +2 more
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Lipids in Health and Disease, 2012 Background The single and combined effects of scavenger receptor-BI (SR-BI), ATP-binding cassette transporter (ABC) A1 and G1 on cholesterol efflux from Chinese Hamster Ovary (CHO) cells were investigated. Results When apolipoproteinA-I (apoA-I) was used
Song Guohua +7 more
doaj +1 more source
A Closer Look at Cardioprotective Function of HDL: Revise the HDL – Cholesterol Hypothesis? [PDF]
, 2014 BACKGROUND: The strong inverse association of plasma levels of high-density lipoprotein (HDL) cholesterol with coronary heart disease (CHD) found in human epidemiological studies led to the development of the ‘HDL cholesterol hypothesis', which posits ...
Meiliana, A. (Anna), Wijaya, A. (Andi)
core
Ocular surface epithelia contain ABCG2-dependent side population cells exhibiting features associated with stem cells. [PDF]
, 2005 When cell populations are incubated with the DNA-binding dye Hoechst 33342 and subjected to flow cytometry analysis for Hoechst 33342 emissions, active efflux of the dye by the ABCG2/BCRP1 transporter causes certain cells to appear as a segregated cohort,
Akinci, M A Murat +5 more
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ABCC6 knockdown in HepG2 cells induces a senescent-like cell phenotype
Cellular & Molecular Biology Letters, 2017 Background Pseudoxanthoma elasticum (PXE) is characterized by progressive ectopic mineralization of elastic fibers in dermal, ocular and vascular tissues. No effective treatment exists.
Rocchina Miglionico +6 more
doaj +1 more source
SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL
Journal of Lipid Research, 2008 This study compares the roles of ABCG1 and scavenger receptor class B type I (SR-BI) singly or together in promoting net cellular cholesterol efflux to plasma HDL containing active LCAT. In transfected cells, SR-BI promoted free cholesterol efflux to HDL,
Laurent Yvan-Charvet +7 more
doaj +1 more source
Frontiers in PharmacologyAcute lymphoblastic leukemia (ALL) is a prevalent hematologic malignancy in children, and methotrexate (MTX) is a widely employed curative treatment. Despite its common use, clinical resistance to MTX is frequently encountered.
Yao Chen +9 more
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