Results 111 to 120 of about 1,912,571 (214)

Up-regulation of ABCG1 is associated with methotrexate resistance in acute lymphoblastic leukemia cells

Frontiers in Pharmacology
Acute lymphoblastic leukemia (ALL) is a prevalent hematologic malignancy in children, and methotrexate (MTX) is a widely employed curative treatment. Despite its common use, clinical resistance to MTX is frequently encountered.
Yao Chen, Houshun Fang, Huiying Sun, Xiaoyu Wu, Yan Xu, Bin-Bing S. Zhou, Bin-Bing S. Zhou, Bin-Bing S. Zhou, Hui Li, Hui Li   +9 more
doaj   +1 more source

Lung Cancer Inhibition by Betulinic Acid Nanoparticles via Adenosine 5'-Triphosphate (ATP)-Binding Cassette Transporter G1 Gene Downregulation. [PDF]

Med Sci Monit, 2020
Zhao H, Mu X, Zhang X, You Q.
europepmc   +1 more source

Laminaria japonica Aresch-Derived Fucoidan Ameliorates Hyperlipidemia by Upregulating LXRs and Suppressing SREBPs

Cardiovascular Therapeutics
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, and hyperlipidemia is one major inducing factor of CVD. It is worthy to note that fucoidans are reported to have hypolipidemic activity with species specificity ...
Yan Zhang, Tian Liu, Ze-Jie Qu, Xue Wang, Wen-Gang Song, Shou-Dong Guo   +5 more
doaj   +1 more source

Structural Features of the ATP-Binding Cassette (ABC) Transporter ABCA3

, 2015
In this review we reported and discussed the structural features of the ATP-Binding Cassette (ABC) transporter ABCA3 and how the use of bioinformatics tools could help researchers to obtain a reliable structural model of this important transporter.
Alessandro Paolini, Andrea Masotti, Antonella Baldassarre, Ilaria Del Gaudio   +3 more
core   +1 more source

ATP-Binding Cassette Transporter of Clinical Significance: Sideroblastic Anemia [PDF]

The ATP-binding cassette (ABC) transporters are a vast group of 48 membrane proteins, some of which are of notable physiological and clinical importance.
Harris, Neil, Neil Harris, Tung Wynn, Reema Kashif, Ogunbileje, John O., Kashif, Reema, Stover, Brian, Bremansu Osa-Andrews, Wynn, Tung, Osa-Andrews, Bremansu, Brian Stover, John O. Ogunbileje   +11 more
core   +1 more source

Caractérisation des rôles du transporteur ATP-Binding cassette G1 (ABCG1) au sein du macrophage humain

, 2008
The macrophage plays a key role in atherogenesis, including in the uptake of cholesterol which lead to the formation of fatty streaks. So its ability to eliminate cholesterol in excess is critical for the development of pathology.
Larrède, Sandra
core   +3 more sources

Loss of IGFBP-6 promotes monocyte-driven atherogenesis in periodontal disease

Scientific Reports
Periodontitis has been associated with an increased risk of atherosclerosis, potentially through altered systemic monocyte and macrophage function.
Dáire Shanahan, Georgios Kremastiotis, Kerry Wadey, Claudine Hodgson, Joon Seong, Nicola West, Angela H. Nobbs, Jason Johnson, Sarah George   +8 more
doaj   +1 more source

Characterisation of the vibrio cholerae antibiotic resistance var operon [PDF]

, 2007
The discovery and use of antibiotics in the chemotherapy of bacterial infections has revolutionised medicine as it is today. Unfortunately, the progressive use of antibiotics has promoted the evolution of bacterial defences against these mediators and ...
Massam-Wu, Teresa
core  

Cyanidin-3-glucoside: targeting atherosclerosis through gut microbiota and anti-inflammation

Frontiers in Nutrition
With the shifting global disease spectrum, atherosclerosis (AS) has emerged as a leading contributor to mortality worldwide, with associated cardiovascular diseases (CVDs) representing the predominant cause of death. AS, a chronic inflammatory pathology,
Zihan Tang
doaj   +1 more source

The ATP-binding cassette (ABC) transporter Bpt1p mediates vacuolar sequestration of glutathione conjugates in yeast.

, 2002
Vacuolar sequestration or cellular extrusion of glutathione-conjugated xenobiotics and catabolites by ATP-binding cassette (ABC) transporters is an important detoxification mechanism operating in many species.
Mamnun YM, Martinoia E, Schüller C, Wolfger H, Klein M, Kuchler K, Eggmann T   +6 more
core   +1 more source