Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice [PDF]
Journal of Translational Medicine, 2018 Background Scavenger receptor class B type I (SR-BI) plays a key role in high density lipoproteins (HDL) metabolism. SR-BI deficiency in mice results in enhanced susceptibility to atherosclerosis with abnormal large, cholesterol enriched, and functional ...
Jia Cao +5 more
doaj +5 more sources
Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. [PDF]
PLoS ONE, 2012 Farnesoid X receptor (FXR) is a nuclear receptor and a key regulator of liver cholesterol and triglyceride homeostasis. Scavenger receptor class B type I (SR-BI) is critical for reverse cholesterol transport (RCT) by transporting high-density lipoprotein
Guodong Li +7 more
doaj +4 more sources
Scavenger Receptor Class B Type I Is a Plasma Membrane Cholesterol Sensor [PDF]
Circulation Research, 2013 Rationale: Signal initiation by the high-density lipoprotein (HDL) receptor scavenger receptor class B, type I (SR-BI), which is important to actions of HDL on endothelium and other processes, requires cholesterol efflux and the C-terminal transmembrane domain.
Etienne Morel +2 more
exaly +5 more sources
Scavenger receptor class B type I: a multifunctional receptor [PDF]
Annals of the New York Academy of Sciences, 2011 The scavenger receptor class B type I (SR‐B1) plays an important role in meditating the uptake of HDL‐derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. In addition to being ubiquitous, SR‐B1 is a high‐density lipoprotein (HDL) receptor in many tissues, though the mechanism by which SR‐B1 does this is unclear.
VALACCHI, Giuseppe +3 more
openaire +4 more sources
Dimerization of the scavenger receptor class B type I [PDF]
Journal of Lipid Research, 2004 This study has examined the dimeric/oligomeric forms of scavenger receptor class B type I (SR-BI) and its alternatively spliced form, SR-BII, in a diverse group of cells and tissues: i.e., normal and hormonally altered tissues of mice and rats as well as
Eve Reaven +4 more
doaj +2 more sources
Lp-PLA2, scavenger receptor class B type I gene (SCARB1) rs10846744 variant, and cardiovascular disease. [PDF]
PLoS ONE, 2018 BackgroundWe previously reported association of SCARB1 SNP rs10846744 with common carotid IMT (cIMT) and cardiovascular disease (CVD) events. Since rs10846744 has been reported in association with Lp-PLA2 mass and activity, we hypothesized that ...
Ani Manichaikul +19 more
doaj +2 more sources
Sterol regulation of scavenger receptor class B type I in macrophages [PDF]
Journal of Lipid Research, 2004 Scavenger receptor class B type I (SR-BI) is expressed in macrophages, but its role in sterol trafficking in these cells remains controversial. We examined the effect of sterol loading on SR-BI expression in human monocytes/macrophages, mouse peritoneal ...
Liqing Yu +3 more
doaj +3 more sources
Scavenger receptor class B type I localizes to a late endosomal compartment [PDF]
Journal of Lipid Research, 2008 Scavenger receptor class B type I (SR-BI) has an established role in mediating the selective uptake of cholesterol from HDL in hepatocytes, steroidogenic cells, and other tissues.
Malika Ahras, Thet Naing, Ruth McPherson
doaj +3 more sources
Scavenger receptor class B type I as a receptor for oxidized low density lipoprotein [PDF]
Journal of Lipid Research, 2001 Scavenger receptor class B type I (SR-BI) has been established as the primary mediator of the selective transfer of lipids from HDL to mammalian cells.
Kristin Gillotte-Taylor +4 more
doaj +3 more sources
Remodeling of HDL remnants generated by scavenger receptor class B type I [PDF]
Journal of Lipid Research, 2004 Scavenger receptor class B type I (SR-BI) mediates the selective transfer of cholesteryl ester from HDL to cells. We previously established that SR-BI overexpressed in livers of apolipoprotein A-I-deficient mice processes exogenous human HDL2 to ...
Nancy R. Webb +5 more
doaj +3 more sources