Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma [PDF]
BMC Cancer, 2018 Background Scavenger receptor class B type I (SR-BI) has been reported to be involved in carcinogenesis of several human cancers. However, it is currently unknown whether SR-BI plays a role in clear cell renal cell carcinoma (ccRCC).
Guang-hua Xu +16 more
doaj +3 more sources
SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis. [PDF]
Trends Endocrinol Metab, 2017 The HDL receptor scavenger receptor class B type I (SR-BI) plays crucial roles in cholesterol homeostasis, lipoprotein metabolism, and atherosclerosis. Hepatic SR-BI mediates reverse cholesterol transport (RCT) by the uptake of HDL cholesterol for routing to the bile.
Linton MF, Tao H, Linton EF, Yancey PG.
europepmc +5 more sources
C323 of SR-BI is required for SR-BI-mediated HDL binding and cholesteryl ester uptake[S] [PDF]
Journal of Lipid Research, 2011 Scavenger receptor BI (SR-BI) is an HDL receptor. It binds HDL and mediates the uptake of cholesteryl ester from HDL. Early studies have pointed out that the extracellular domain of SR-BI is critical for SR-BI-mediated cholesteryl ester uptake.
Ling Guo +4 more
doaj +5 more sources
Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI [PDF]
Scientific Reports, 2017 SR-BI is the main receptor for high density lipoproteins (HDL) and mediates the bidirectional transport of lipids, such as cholesterol and vitamin E, between these particles and cells. During early development, SR-BI is expressed in extraembryonic tissue,
Nicolás Santander +9 more
doaj +3 more sources
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport. [PDF]
Biochemistry, 2014 High-density lipoproteins (HDLs) are athero-protective, primarily because of their ability to promote cholesterol flux from peripheral tissues to the liver by reverse cholesterol transport (RCT).
Kartz GA +3 more
europepmc +5 more sources
Targeting SR-BI for Cancer Diagnostics, Imaging and Therapy. [PDF]
Front Pharmacol, 2016 Scavenger receptor class B type I (SR-BI) plays an important role in trafficking cholesteryl esters between the core of high density lipoprotein and the liver. Interestingly, this integral membrane protein receptor is also implicated in the metabolism of
Rajora MA, Zheng G.
europepmc +6 more sources
Mechanism for the selective uptake of macular carotenoids mediated by the HDL cholesterol receptor SR-BI. [PDF]
Exp Eye Res, 2023 The macular carotenoids lutein and zeaxanthin are taken up from the bloodstream into the human retina through a selective process, for which the HDL cholesterol receptor scavenger receptor BI (SR-BI) in the cells of retinal pigment epithelium (RPE) is ...
Li B +9 more
europepmc +2 more sources
Macrophage SR-BI modulates autophagy via VPS34 complex and PPARα transcription of Tfeb in atherosclerosis. [PDF]
J Clin Invest, 2021 Autophagy modulates lipid turnover, cell survival, inflammation and atherogenesis. Scavenger receptor class B type I (SR-BI) plays a crucial role in lysosome function. Here, we demonstrate that SR-BI regulates autophagy in atherosclerosis. SR-BI deletion
Tao H +8 more
europepmc +2 more sources
High-Density Lipoprotein Therapy in Stroke: Evaluation of Endothelial SR-BI-Dependent Neuroprotective Effects. [PDF]
Int J Mol Sci, 2020 High-density lipoproteins (HDLs) display endothelial protective effects. We tested the role of SR-BI, an HDL receptor expressed by endothelial cells, in the neuroprotective effects of HDLs using an experimental model of acute ischemic stroke.
Tran-Dinh A +10 more
europepmc +2 more sources
The potential role of scavenger receptor B type I (SR‐BI) in SARS‐CoV‐2 infection [PDF]
Immunity, Inflammation and Disease, 2023 Scavenger receptor type B I (SR‐BI), the major receptor for high‐density lipoprotein (HDL) mediates the delivery of cholesterol ester and cholesterol from HDL to the cell membrane.
Luay Alkazmi +6 more
doaj +2 more sources