C323 of SR-BI is required for SR-BI-mediated HDL binding and cholesteryl ester uptake[S] [PDF]
Journal of Lipid Research, 2011 Scavenger receptor BI (SR-BI) is an HDL receptor. It binds HDL and mediates the uptake of cholesteryl ester from HDL. Early studies have pointed out that the extracellular domain of SR-BI is critical for SR-BI-mediated cholesteryl ester uptake.
Ling Guo +4 more
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The potential role of scavenger receptor B type I (SR‐BI) in SARS‐CoV‐2 infection [PDF]
Immunity, Inflammation and Disease, 2023 Scavenger receptor type B I (SR‐BI), the major receptor for high‐density lipoprotein (HDL) mediates the delivery of cholesterol ester and cholesterol from HDL to the cell membrane.
Luay Alkazmi +6 more
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Alternative forms of the scavenger receptor BI (SR-BI)
Journal of Lipid Research, 1997 The class B, type I scavenger receptor has been implicated as a receptor for high density lipoprotein (HDL). We have isolated a murine cDNA clone encoding an alternative form of SR-BI that differs in the putative cytoplasmic domain of the receptor.
N R Webb +4 more
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SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport. [PDF]
Biochemistry, 2014 High-density lipoproteins (HDLs) are athero-protective, primarily because of their ability to promote cholesterol flux from peripheral tissues to the liver by reverse cholesterol transport (RCT). The delivery of HDL-cholesteryl esters (CE) into cells is mediated by the HDL receptor, scavenger receptor class B type I (SR-BI), a promising target for ...
Kartz GA +3 more
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Targeting SR-BI for Cancer Diagnostics, Imaging and Therapy. [PDF]
Front Pharmacol, 2016 Scavenger receptor class B type I (SR-BI) plays an important role in trafficking cholesteryl esters between the core of high density lipoprotein and the liver. Interestingly, this integral membrane protein receptor is also implicated in the metabolism of cholesterol by cancer cells, whereby overexpression of SR-BI has been observed in a number of ...
Rajora MA, Zheng G.
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SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis. [PDF]
Trends Endocrinol Metab, 2017 The HDL receptor scavenger receptor class B type I (SR-BI) plays crucial roles in cholesterol homeostasis, lipoprotein metabolism, and atherosclerosis. Hepatic SR-BI mediates reverse cholesterol transport (RCT) by the uptake of HDL cholesterol for routing to the bile.
Linton MF, Tao H, Linton EF, Yancey PG.
europepmc +4 more sources
Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma [PDF]
BMC Cancer, 2018 Background Scavenger receptor class B type I (SR-BI) has been reported to be involved in carcinogenesis of several human cancers. However, it is currently unknown whether SR-BI plays a role in clear cell renal cell carcinoma (ccRCC).
Guang-hua Xu +16 more
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SR-BI Interactome Analysis Reveals a Proviral Role for UGGT1 in Hepatitis C Virus Entry [PDF]
Frontiers in Microbiology, 2019 Hepatitis C virus (HCV) entry is mediated by multiple co-receptors including scavenger receptor class B, type I (SR-BI). To elucidate the interactome of human SR-BI, we performed immunoprecipitation (IP) experiment coupled with mass spectrometry (MS ...
Jiazhao Huang +7 more
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Different Functions of Human Scavenger Receptors BI and BII Overexpressed in a Murine Abdominal Sepsis Model [PDF]
BiomoleculesClass B scavenger receptor BI splice variants (SR-BI) and BII (SR-BII) internalize lipoproteins but also bind and internalize bacteria. Their individual roles in sepsis are unknown. We overexpressed human SR-BI or BII in transgenic mice, primarily in the
Naoki Hayase +8 more
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Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI [PDF]
Scientific Reports, 2017 SR-BI is the main receptor for high density lipoproteins (HDL) and mediates the bidirectional transport of lipids, such as cholesterol and vitamin E, between these particles and cells. During early development, SR-BI is expressed in extraembryonic tissue,
Nicolás Santander +9 more
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