Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells. [PDF]
, 2006 Cell entry of hepatitis C virus, pseudoparticles (HCVpp) and cell culture grown virus (HCVcc), requires the interaction of viral glycoproteins with CD81 and other as yet unknown cellular factors.
Boullier, Agnès +6 more
core +1 more source
Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages
Journal of Lipid Research, 2012 Scavenger receptor BI (SR-BI), an HDL receptor, plays a key role in reverse cholesterol transport. In mice, disruption of SR-BI results in hypersensitivity to lipopolysaccharide (LPS) and bacteria-induced septic shock due to adrenal insufficiency and ...
Lei Cai +4 more
doaj +1 more source
Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo
Journal of Lipid Research, 2008 Scavenger receptor class B type I (SR-BI) functions as an HDL receptor that promotes the selective uptake of cholesteryl esters (CEs). The physiological role of SR-BI in VLDL metabolism, however, is largely unknown.
Miranda Van Eck +6 more
doaj +1 more source
A library of infectious hepatitis C viruses with engineered mutations in the E2 gene reveals growth-adaptive mutations that modulate interactions with scavenger receptor class B type I [PDF]
, 2016 While natural hepatitis C virus (HCV) infection results in highly diverse quasispecies of related viruses over time, mutations accumulate more slowly in tissue culture, in part because of the inefficiency of replication in cells.
Chen, Kevin +8 more
core +2 more sources
13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages [PDF]
, 2011 Background Synthetic activators of peroxisome proliferator-activated receptors (PPARs) stimulate cholesterol removal from macrophages through PPAR-dependent up-regulation of liver × receptor α (LXRα) and subsequent induction of cholesterol ...
Ines InesKämmerer +5 more
core +2 more sources
Journal of Lipid Research, 2001 The current study used the human Caco-2 cell line and mouse intestine to explore the topology of expression of the class B type I scavenger receptor (SR-BI) in intestinal cells.
Sheng F. Cai +3 more
doaj +1 more source
Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors [PDF]
, 2010 Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible for this narrow species tropism are not well defined.
Bitzegeio, Julia +10 more
core +2 more sources
17β-Estradiol promotes the up-regulation of SR-BII in HepG2 cells and in rat livers
Journal of Lipid Research, 2001 The scavenger receptor class B type I (SR-BI) binds to HDL and mediates the selective uptake of cholesterol esters from HDL to cells. SR-BII is an alternatively spliced product of the SR-BI gene that only differs in the C-terminal cytoplasmic domain ...
Gregory A. Graf +2 more
doaj +1 more source
Excess cholesterol induces mouse egg activation and may cause female infertility [PDF]
, 2013 The HDL receptor scavenger receptor, class B type I (SR-BI) controls the structure and fate of plasma HDL. Female SR-BI KO mice are infertile, apparently because of their abnormal cholesterol-enriched HDL particles.
Albertini, David F. +15 more
core +1 more source
Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions
Journal of Lipid Research, 2021 : HDL and its primary receptor, scavenger receptor class B type I (SR-BI), work together to promote the clearance of excess plasma cholesterol, thereby protecting against atherosclerosis. Human variants of SR-BI have been identified in patients with high
Sarah C. May +3 more
doaj +1 more source