Results 21 to 30 of about 1,272,764 (261)
Quantification of apolipoprotein E receptors in human brain-derived cell lines by real-time polymerase chain reaction [PDF]
, 2004 Apolipoprotein (apo) E4 is a risk factor for Alzheimer's disease (AD) and other neurodegenerative diseases, compared to wild-type apoE3. The mechanism(s) is unknown.
Owen, JS +7 more
core +1 more source
Journal of Lipid Research, 2006 Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) and facilitates the efflux of unesterified cholesterol. SR-BI expression in macrophages presumably plays a role in atherosclerosis.
May Brundert +5 more
doaj +1 more source
Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages
Journal of Lipid Research, 2012 Scavenger receptor BI (SR-BI), an HDL receptor, plays a key role in reverse cholesterol transport. In mice, disruption of SR-BI results in hypersensitivity to lipopolysaccharide (LPS) and bacteria-induced septic shock due to adrenal insufficiency and ...
Lei Cai +4 more
doaj +1 more source
Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo
Journal of Lipid Research, 2008 Scavenger receptor class B type I (SR-BI) functions as an HDL receptor that promotes the selective uptake of cholesteryl esters (CEs). The physiological role of SR-BI in VLDL metabolism, however, is largely unknown.
Miranda Van Eck +6 more
doaj +1 more source
Scavenger receptor SR-BI in macrophage lipid metabolism [PDF]
Atherosclerosis, 2011 To investigate the mechanisms by which macrophage scavenger receptor BI (SR-BI) regulates macrophage cholesterol homeostasis and protects against atherosclerosis.The expression and function of SR-BI was investigated in cultured mouse bone marrow-derived macrophages (BMM).
Ailing, Ji +6 more
openaire +2 more sources
Influence of the HDL Receptor SR-BI on Lipoprotein Metabolism and Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2003 The scavenger receptor class B type I (SR-BI) was the first molecularly well-defined cell-surface HDL receptor to be described. SR-BI mediates selective HDL cholesterol uptake by formation of a productive lipoprotein/receptor complex, which requires specific structural domains and conformation states of apolipoprotein A-I present in HDL particles.
Trigatti, BL, Krieger, M, Rigotti, A
openaire +4 more sources
Journal of Lipid Research, 2001 The current study used the human Caco-2 cell line and mouse intestine to explore the topology of expression of the class B type I scavenger receptor (SR-BI) in intestinal cells.
Sheng F. Cai +3 more
doaj +1 more source
17β-Estradiol promotes the up-regulation of SR-BII in HepG2 cells and in rat livers
Journal of Lipid Research, 2001 The scavenger receptor class B type I (SR-BI) binds to HDL and mediates the selective uptake of cholesterol esters from HDL to cells. SR-BII is an alternatively spliced product of the SR-BI gene that only differs in the C-terminal cytoplasmic domain ...
Gregory A. Graf +2 more
doaj +1 more source
SR-BI Selective Lipid Uptake [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2009 Objective— The purpose of this study was to investigate the interaction of SAA and SR-BI in remodeling of acute phase HDL (AP HDL). Methods and Results— We used SAA and SR-BI adenoviral vector expression models to study the ...
Maria C, de Beer +6 more
openaire +2 more sources
Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions
Journal of Lipid Research, 2021 : HDL and its primary receptor, scavenger receptor class B type I (SR-BI), work together to promote the clearance of excess plasma cholesterol, thereby protecting against atherosclerosis. Human variants of SR-BI have been identified in patients with high
Sarah C. May +3 more
doaj +1 more source