SR-BI mediates neutral lipid sorting from LDL to lipid droplets and facilitates their formation. [PDF]
PLoS ONE, 2020 SR-BI binds various lipoproteins, including HDL, LDL as well as VLDL, and mediates selective cholesteryl ester (CE) uptake. HDL derived CE accumulates in cellular lipid droplets (LDs), which also store triacylglycerol (TAG).
Tatyana G Vishnyakova +12 more
doaj +2 more sources
Journal of Lipid Research, 2013 Reverse cholesterol transport (RCT) can proceed through the classic hepatobiliary route or through the nonbiliary transintestinal cholesterol efflux (TICE) pathway.
Kanwardeep S. Bura +16 more
doaj +2 more sources
Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI. [PDF]
Human Molecular Genetics, 2013 The srbi gene encodes a lipoprotein receptor with high affinity for high density lipoprotein that is mainly expressed in the liver and in steroidogenic tissues. Disruption of this gene in mice and mutations in humans lead to alterations in lipoprotein metabolism and/or fertility. During murine development, scavenger receptor class B member I (SR-BI) is
Nicolás Santander +6 more
semanticscholar +7 more sources
Functional characterization of newly-discovered mutations in human SR-BI. [PDF]
PLoS ONE, 2012 In rodents, SR-BI has been firmly established as a physiologically relevant HDL receptor that mediates removal of HDL-cholesteryl esters (CE). However, its role in human lipoprotein metabolism is less defined.
Alexandra C Chadwick, Daisy Sahoo
doaj +4 more sources
Consequences of over-expression of rat Scavenger Receptor, SR-BI, in an adrenal cell model [PDF]
Nutrition & Metabolism, 2006 Background The plasma membrane scavenger receptor, SR-BI, mediates the 'selective uptake' process by which cholesteryl esters (CE) from exogenously supplied HDL are taken up by target cells.
Azhar Salman +3 more
doaj +2 more sources
Malignant Phenotypes in Metastatic Melanoma are Governed by SR-BI and its Association with Glycosylation and STAT5 Activation. [PDF]
Mol Cancer Res, 2018 Kinslechner K +10 more
europepmc +2 more sources
NMR Structure of the C-Terminal Transmembrane Domain of the HDL Receptor, SR-BI, and a Functionally Relevant Leucine Zipper Motif. [PDF]
Structure, 2017 Chadwick AC +7 more
europepmc +2 more sources
Human SR-BI and SR-BII Potentiate Lipopolysaccharide-Induced Inflammation and Acute Liver and Kidney Injury in Mice. [PDF]
J Immunol, 2016 Baranova IN +13 more
europepmc +2 more sources
A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis. [PDF]
Cardiovasc Res, 2015 Armstrong SM +15 more
europepmc +2 more sources
Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents. [PDF]
Hepatology, 2014 Vercauteren K +13 more
europepmc +2 more sources