Results 1 to 10 of about 9,898 (104)

Lipid metabolism in γδ T-cell activation: Implications for immunotherapy in ovarian cancer [PDF]

Translational Oncology
Ovarian cancer (OC) remains a leading cause of cancer-related mortality among women worldwide, largely due to asymptomatic progression, late-stage diagnosis, therapeutic resistance, and profound immunosuppression within the tumor microenvironment (TME ...
Karolina Stirblyte, Yazid Ghanem, Mark Bates, Steven G. Gray, Feras Abu Saadeh, Cara Martin, Sharon O'Toole, John J. O'Leary, Derek G. Doherty, Bashir M. Mohamed   +9 more
doaj   +2 more sources

CD36 Signal Transduction in Metabolic Diseases: Novel Insights and Therapeutic Targeting

Cells, 2021
The cluster of differentiation 36 (CD36) is a scavenger receptor present on various types of cells and has multiple biological functions that may be important in inflammation and in the pathogenesis of metabolic diseases, including diabetes.
Kyu Chang Won, Udayakumar Karunakaran, Jun Sung Moon   +2 more
exaly   +3 more sources

Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women [PDF]

Diabetes & Metabolism Journal, 2020
BackgroundMembrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity ...
Yeli Wang, Jingwen Zhu, Sarah Aroner, Kim Overvad, Tianxi Cai, Ming Yang, Anne Tjønneland, Aase Handberg, Majken K. Jensen   +8 more
doaj   +1 more source

The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond [PDF]

Diabetes & Metabolism Journal, 2020
Impaired β-cell function is the key pathophysiology of type 2 diabetes mellitus, and chronic exposure of nutrient excess could lead to this tragedy.
Jun Sung Moon, Udayakumar Karunakaran, Elumalai Suma, Seung Min Chung, Kyu Chang Won   +4 more
doaj   +1 more source

Matching strategy for patients with platelet transfusion refractoriness caused by compound antibodies against HLA and CD36

Zhongguo shuxue zazhi, 2023
Objective To search compatible and suitable platelets for platelet transfusion refractoriness (PTR) patient caused by compound antibodies against HLA and CD36.
Jing DENG, Xiuzhang XU, Huibin ZHONG, Bi ZHONG, Yangkai CHEN, Jing LIU, Haoqiang DING, Wenjie XIA, Dawei CHEN, Yaori XU, Xin YE   +10 more
doaj   +1 more source

Analysis and prospect of platelet compatible transfusion

Zhongguo shuxue zazhi, 2022
Platelet compatible transfusion can effectively solve the immune mediated platelet transfusion refractoriness (PTR), save platelet resources and improve blood safety.
Faming ZHU, Wei MAO, Zhixin ZHANG
doaj   +1 more source

Hypochlorous acid-modified human serum albumin suppresses MHC class II - dependent antigen presentation in pro-inflammatory macrophages

Redox Biology, 2021
Macrophages are innate immune cells that internalize and present exogenous antigens to T cells via MHC class II proteins. They operate at sites of infection in a highly inflammatory environment, generated in part by reactive oxygen species, in particular
Agnes Ulfig, Verian Bader, Marharyta Varatnitskaya, Natalie Lupilov, Konstanze F. Winklhofer, Lars I. Leichert   +5 more
doaj   +1 more source

Neonatal Intracranial Hemorrhage with a Dramatic Outcome Due to Maternal Anti CD36 Antibodies

Reports, 2019
Fetal/neonatal allo-immune thrombocytopenia (FNAIT) results from maternal immunization against fetal platelet-specific antigens (HPA) inherited from the father. Most cases involve HPA located on glycoproteins (GP) IbIX, IaIIa and IIbIIIa.
Gérald Bertrand, Virginie Renac, Marie-Christine Lefaix, Carl Nivet, Elise Trudel, Lucie Richard   +5 more
doaj   +1 more source

Nanoparticles Containing Curcumin Useful for Suppressing Macrophages In Vivo in Mice. [PDF]

PLoS ONE, 2015
To explore a novel method using liposomes to suppress macrophages, we screened food constituents through cell culture assays. Curcumin was one of the strongest compounds exhibiting suppressive effects on macrophages. We subsequently tried various methods
Chie Amano, Hideki Minematsu, Kazuyo Fujita, Shinki Iwashita, Masaki Adachi, Koichi Igarashi, Shuji Hinuma   +6 more
doaj   +1 more source

Overcoming β-Cell Dysfunction in Type 2 Diabetes Mellitus: CD36 Inhibition and Antioxidant System [PDF]

Diabetes & Metabolism Journal
Type 2 diabetes mellitus (T2DM) is marked by chronic hyperglycemia, gradually worsening β-cell failure, and insulin resistance. Glucotoxicity and oxidative stress cause β-cell failure by increasing reactive oxygen species (ROS) production, impairing ...
Il Rae Park, Yong Geun Chung, Kyu Chang Won   +2 more
doaj   +1 more source