Results 31 to 40 of about 16,744 (229)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Children with cerebral malaria or severe malarial anaemia lack immunity to distinct variant surface antigen subsets [PDF]

, 2018
Variant surface antigens (VSAs) play a critical role in severe malaria pathogenesis. Defining gaps, or “lacunae”, in immunity to these Plasmodium falciparum antigens in children with severe malaria would improve our understanding of vulnerability to ...
A Bengtsson, A Claessens, A Djimde, A Salanti, A Salanti, BP Goncalves, C Lessa-Aquino, CI Newbold, CJ Treutiger, CW Wang, D Coulibaly, DH Davies, DI Baruch, F Lennartz, GI Bertin, GK Cham, GM Warimwe, HM Kyriacou, JA Chan, JA Chan, JD Smith, JT Griffin, K Marsh, KE Lyke, KE Lyke, L Turner, M Avril, M Fried, MA Travassos, MA Travassos, MJ Gardner, PD Crompton, RW Snow, S Gupta, SC Murphy, Severe falciparum malaria, SJ Rogerson, SS Oh, T Lavstsen, TE Taylor, TW Mwangi, XZ Su, Y Zhang   +42 more
core   +2 more sources

The role and mechanism of action of endoplasmic reticulum transmembrane protein 166 in liver lipid metabolism [PDF]

精准医学杂志
Objective To investigate the role and specific molecular mechanism of action of endoplasmic reticulum transmembrane protein 166 (TMEM166) in liver lipid metabolism. Methods Tmem166flox/flox mice were crossed with Alb-Cre mice, and the offspring Tmem166+/+
LI Lianhui, YANG Di, ZANG Kailai, SUN Yani, DU Qiyuan, LI Ning
doaj   +1 more source

Phenotypic and functional changes in blood monocytes following adherence to endothelium. [PDF]

PLoS ONE, 2012
ObjectiveBlood monocytes are known to express endothelial-like genes during co-culture with endothelium. In this study, the time-dependent change in the phenotype pattern of primary blood monocytes after adhering to endothelium is reported using a novel ...
Colin Tso, Kerry-Anne Rye, Philip Barter
doaj   +1 more source

The role of Plasmodium falciparum var genes in malaria in pregnancy [PDF]

, 2004
Sequestration of Plasmodium falciparum-infected erythrocytes in the placenta is responsible for many of the harmful effects of malaria during pregnancy. Sequestration occurs as a result of parasite adhesion molecules expressed on the surface of infected ...
Andrews, Baruch, Beeson, Beeson, Beeson, Brabin, Buffet, Chen, Costa, Creasey, Dorman, Duffy, Duffy, Flick, Freitas-Junior, Fried, Fried, Fried, Fried, Gardner, Jensen, Kyes, Kyes, Lekana Douki, McCormick, McGregor, Menendez, Menendez, Nosten, O'Neil-Dunne, Reeder, Reeder, Ricke, Rowe, Rowe, Salanti, Salanti, Shulman, Smith, Smith, Smith, Smith, Staalsoe, Staalsoe, Steketee, Su, Suguitan, Taylor, Taylor, Walter, Ward, Winter   +51 more
core   +1 more source

Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia [PDF]

, 2014
Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene. Although mechanisms of BCR/ABL1-induced transformation are well-defined, little is known about effector-molecules contributing to malignant expansion and ...
Bilban, Martin, Blatt, Katharina, Cerny-Reiterer, Sabine, Herndlhofer, Susanne, Herrmann, Harald, Hoermann, Grego, Holyoake, Tessa L., Mannhalter, Christine, Mayerhofer, Matthias, Rulicke, Thomas, Sadovnik, Irina, Sperr, Wolfgang R., Stefanzl, Gabriele, Streubel, Berthold, Valent, Peter, Willmann, Michael   +15 more
core   +1 more source

Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studiesResearch in context

EBioMedicine, 2019
Background: Endemic Burkitt lymphoma (eBL) is an aggressive childhood B-cell lymphoma linked to Plasmodium falciparum (Pf) malaria in sub-Saharan Africa.
Andriy Derkach, Isaac Otim, Ruth M. Pfeiffer, Olusegun O. Onabajo, Ismail D. Legason, Hadijah Nabalende, Martin D. Ogwang, Patrick Kerchan, Ambrose O. Talisuna, Leona W. Ayers, Steven J. Reynolds, Francis Nkrumah, Janet Neequaye, Kishor Bhatia, Thor G. Theander, Ludmila Prokunina-Olsson, Louise Turner, James J. Goedert, Thomas Lavstsen, Sam M. Mbulaiteye   +19 more
doaj   +1 more source

Acquisition of naturally acquired antibody response to Plasmodium falciparum erythrocyte membrane protein 1-DBLα and differential regulation of IgG subclasses in severe and uncomplicated malaria

Asian Pacific Journal of Tropical Biomedicine, 2017
Objectives: To explore whether individuals infected with Plasmodium falciparum (P. falciparum) develop antibodies directed against PfEMP1-DBLα, and to assess their IgG subclass distribution in severe and uncomplicated malaria. Methods: The anti-PfDBLα
Natharinee Horata, Kiattawee Choowongkomon, Siriluk Ratanabunyong, Jarinee Tongshoob, Srisin Khusmith   +4 more
doaj   +1 more source

Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. [PDF]

, 2018
Oxidized phospholipids (OxPL) are ubiquitous, are formed in many inflammatory tissues, including atherosclerotic lesions, and frequently mediate proinflammatory changes 1 .
Binder, Christoph J, Bowden, Karen, Diehl, Cody, Gaddis, Dalia E, Glass, Christopher K, Gonen, Ayelet, Hedrick, Catherine C, Hung, Ming-Yow, Ley, Klaus, MacDonald, Jeffrey G, Mellon, Pamela L, Miller, Yury I, Määttä, Antti, Pattison, Jennifer, Peterson, Kirk L, Prohaska, Thomas A, Que, Xuchu, Sun, Xiaoli, Tsimikas, Sotirios, Witztum, Joseph L, Yeang, Calvin, Ylä-Herttuala, Seppo   +21 more
core   +1 more source

Autophagy protein ATG5 regulates CD36 expression and anti-tumor MHC class II antigen presentation in dendritic cells [PDF]

Autophagy, 2019
Macroautophagy/autophagy has been implicated in cytoplasmic and viral antigen presentation on major histocompatibility complex (MHC) class II molecules. However, the role of autophagy in the presentation of phagocytized tumor-associated antigens in vivo remains unclear.
Dong Sun Oh, Heung Kyu Lee
openaire   +2 more sources