Results 31 to 40 of about 9,756 (185)

The role and mechanism of action of endoplasmic reticulum transmembrane protein 166 in liver lipid metabolism [PDF]

精准医学杂志
Objective To investigate the role and specific molecular mechanism of action of endoplasmic reticulum transmembrane protein 166 (TMEM166) in liver lipid metabolism. Methods Tmem166flox/flox mice were crossed with Alb-Cre mice, and the offspring Tmem166+/+
LI Lianhui, YANG Di, ZANG Kailai, SUN Yani, DU Qiyuan, LI Ning
doaj   +1 more source

Phenotypic and functional changes in blood monocytes following adherence to endothelium. [PDF]

PLoS ONE, 2012
ObjectiveBlood monocytes are known to express endothelial-like genes during co-culture with endothelium. In this study, the time-dependent change in the phenotype pattern of primary blood monocytes after adhering to endothelium is reported using a novel ...
Colin Tso, Kerry-Anne Rye, Philip Barter
doaj   +1 more source

PPARα modulation of macrophage polarization and inflammatory signaling in mimic periodontitis [PDF]

Journal of Applied Oral Science
Objective This study investigates the role of peroxisome proliferator-activated receptor alpha (PPARα) in regulating macrophage polarization and inflammatory signaling under stimulation by periodontal pathogens.
HU Arthur, Yvette Y CHEN
doaj   +1 more source

Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studiesResearch in context

EBioMedicine, 2019
Background: Endemic Burkitt lymphoma (eBL) is an aggressive childhood B-cell lymphoma linked to Plasmodium falciparum (Pf) malaria in sub-Saharan Africa.
Andriy Derkach, Isaac Otim, Ruth M. Pfeiffer, Olusegun O. Onabajo, Ismail D. Legason, Hadijah Nabalende, Martin D. Ogwang, Patrick Kerchan, Ambrose O. Talisuna, Leona W. Ayers, Steven J. Reynolds, Francis Nkrumah, Janet Neequaye, Kishor Bhatia, Thor G. Theander, Ludmila Prokunina-Olsson, Louise Turner, James J. Goedert, Thomas Lavstsen, Sam M. Mbulaiteye   +19 more
doaj   +1 more source

Decrease of Very Late Activation Antigen-4 and CD36 on Reticulocytes in Sickle Cell Patients Treated With Hydroxyurea [PDF]

Blood, 1997
Abstract Sickle cell disease (SCD) is characterized by repeated vaso-occlusive events, which result in substantial morbidity. Abnormal adhesion of sickle red blood cells (RBC) to the vascular endothelium is postulated to play a role in the pathogenesis of vaso-occlusion.
L A, Styles, B, Lubin, E, Vichinsky, S, Lawrence, M, Hua, S, Test, F, Kuypers   +6 more
openaire   +2 more sources

Acquisition of naturally acquired antibody response to Plasmodium falciparum erythrocyte membrane protein 1-DBLα and differential regulation of IgG subclasses in severe and uncomplicated malaria

Asian Pacific Journal of Tropical Biomedicine, 2017
Objectives: To explore whether individuals infected with Plasmodium falciparum (P. falciparum) develop antibodies directed against PfEMP1-DBLα, and to assess their IgG subclass distribution in severe and uncomplicated malaria. Methods: The anti-PfDBLα
Natharinee Horata, Kiattawee Choowongkomon, Siriluk Ratanabunyong, Jarinee Tongshoob, Srisin Khusmith   +4 more
doaj   +1 more source

Oxidation by neutrophils-derived HOCl increases immunogenicity of proteins by converting them into ligands of several endocytic receptors involved in antigen uptake by dendritic cells and macrophages. [PDF]

PLoS ONE, 2015
The initiation of adaptive immune responses to protein antigens has to be preceded by their uptake by antigen presenting cells and intracellular proteolytic processing.
Rafał Biedroń, Maciej K Konopiński, Janusz Marcinkiewicz, Szczepan Józefowski   +3 more
doaj   +1 more source

Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparum [PDF]

, 2010
Background: The Plasmodium falciparum parasite is transmitted in its sexual gametocyte stage from man to mosquito and as asexual sporozoites from mosquito to man.
Thor G Theander, Sauerwein, Robert W, Schwank, S., Lavstsen Thomas, Sutherland, CJ, Cornelus C Hermsen, Christian W Wang, Theander, TG, Schwank, Samana, Sutherland Colin J, Hermsen, C.C., Sauerwein, R.W., Hermsen Cornelus C, Thomas Lavstsen, Schwank, S, Theander, T.G., Mwakalinga, SB, Wang, Christian W, Sutherland, Colin J, Sharp Sarah, Mwakalinga Steven B, Sharp, Sarah, Sharp, S., Samana Schwank, Hermsen, CC, Lavstsen, T, Wang Christian W, Sharp, S, Mwakalinga, Steven B, Wang, C.W., Lavstsen, T., Theander, Thor G, Mwakalinga, S.B., Theander Thor G, Colin J Sutherland, Schwank Samana, Sauerwein, RW, Lavstsen, Thomas, Sauerwein Robert W, Steven B Mwakalinga, Hermsen, Cornelus C, Sutherland, C.J., Robert W Sauerwein, Wang, CW, Sarah Sharp   +44 more
core   +1 more source

src‐related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells [PDF]

FEBS Letters, 1994
src‐related cytoplasmic PTKs are physically and functionally associated with cell surface receptors and are involved in signal transduction. In this paper we report the identification of src‐related proteins p59 fyn , pp60c‐scr and p62 yes in human microvascular endothelial cells cultured from normal human skin and their physical association with ...
Bull, Helen A., Brickell, Paul M., Dowd, Pauline M.   +2 more
openaire   +2 more sources

Laboratory diagnosis of chronic myelomonocytic leukemia and progression to acute leukemia in association with chronic lymphocytic leukemia: morphological features and immunophenotypic profile Diagnóstico laboratorial de leucemia mielomonocítica crônica agudizada em associação com leucemia linfocítica crônica: aspectos morfológicos e imunofenotípicos

Revista Brasileira de Hematologia e Hemoterapia, 2012
Chronic myelomonocytic leukemia is a clonal stem cell disorder that is characterized mainly by absolute peripheral monocytosis. This disease can present myeloproliferative and myelodysplastic characteristics.
Iris Mattos Santos, Carine Muniz Ribeiro Franzon, Adolfo Haruo Koga   +2 more
doaj   +1 more source