Autophagy Involves in Differentiation of Insulin-Secreting Cells from Adipose Derived Stem Cells [PDF]
Cell Journal, 2021 Objective: Destruction of pancreatic beta-cells induces an insulin deficiency and causes type 1 diabetes. The role of autophagy in inducing insulin-secreting cells (ISCs) from adipose-derived mesenchymal stem cells (AMSCs) was investigated in the current
Mahmoud Hashemitabar +3 more
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Generation of insulin-secreting cells from mouse gallbladder stem cells by small molecules in vitro [PDF]
Stem Cell Research & Therapy, 2019 Background Stem cell-derived pancreatic β-like cells hold great promise for treating diabetes. Gallbladder belongs to the extrahepatic bile duct system and possesses stem-like cells.
Fei Chen +9 more
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The emerging field of pancreatic tissue engineering: A systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells [PDF]
Journal of Tissue Engineering, 2019 A bioartificial endocrine pancreas is proposed as a future alternative to current treatment options. Patients with insulin-secretion deficiency might benefit.
Gabriel Alexander Salg +8 more
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Microfluidic chip systems for characterizing glucose-responsive insulin-secreting cells equipped with FailSafe kill-switch [PDF]
Stem Cell Research & TherapyBackground Pluripotent cell-derived islet replacement therapy offers promise for treating Type 1 diabetes (T1D), but concerns about uncontrolled cell proliferation and tumorigenicity present significant safety challenges.
Mohammad Izadifar +8 more
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Differentiation of human embryonic stem cells into insulin- secreting cells
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2006 Introduction: Type I diabetes mellitus is caused by autoimmune destruction of the insulin-producing β-cells. A new potential method for curing the disease is transplantation of differentiated insulin- secreting cells from human embryonic stem cells ...
S Mollamohammadi +3 more
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Ca2+-induced Ca2+release in insulin-secreting cells
FEBS Letters, 1992 The sulphydryl reagent thimerosal (50 microM) released Ca2+ from a non-mitochondrial intracellular Ca2+ pool in a dose-dependent manner in permeabilized insulin-secreting RINm5F cells.
Patrik Rorsman, Per-Olof Berggren
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Substantially increased sensitivity of the spot-ELISA for the detection of anti-insulin antibody-secreting cells using a capture antibody and enzyme-conjugated insulin [PDF]
Journal of Immunological Methods, 1990 This paper describes an antibody capture spot-ELISA for the detection of anti-insulin antibody-secreting cells. The assay is based on the binding of secreted antibodies by immobilised isotype-specific capture antibodies and subsequent detection of ...
E Claassen, R Benner
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JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling. [PDF]
PLoS ONE, 2012 We have recently shown that silencing of the brain/islet specific c-Jun N-terminal Kinase3 (JNK3) isoform enhances both basal and cytokine-induced beta-cell apoptosis, whereas silencing of JNK1 or JNK2 has opposite effects. While it is known that JNK1 or
Saida Abdelli, Christophe Bonny
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Spleen extracellular matrix provides a supportive microenvironment for β-cell function [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Type 1 diabetes mellitus is a common autoimmune and multifactorial disorder. Researchers have been interested in making a favorable islet-like tissue model for the treatment of diabetes. The main objective of this study was to determine the
Layasadat Khorsandi +5 more
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Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity. [PDF]
J Biol Chem, 2017 Hahn C +4 more
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