Autophagy Involves in Differentiation of Insulin-Secreting Cells from Adipose Derived Stem Cells [PDF]
Cell Journal, 2021 Objective: Destruction of pancreatic beta-cells induces an insulin deficiency and causes type 1 diabetes. The role of autophagy in inducing insulin-secreting cells (ISCs) from adipose-derived mesenchymal stem cells (AMSCs) was investigated in the current
Mahmoud Hashemitabar +3 more
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Generation of insulin-secreting cells from mouse gallbladder stem cells by small molecules in vitro [PDF]
Stem Cell Research & Therapy, 2019 Background Stem cell-derived pancreatic β-like cells hold great promise for treating diabetes. Gallbladder belongs to the extrahepatic bile duct system and possesses stem-like cells.
Fei Chen +9 more
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The emerging field of pancreatic tissue engineering: A systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells [PDF]
Journal of Tissue Engineering, 2019 A bioartificial endocrine pancreas is proposed as a future alternative to current treatment options. Patients with insulin-secretion deficiency might benefit.
Gabriel Alexander Salg +8 more
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Microfluidic chip systems for characterizing glucose-responsive insulin-secreting cells equipped with FailSafe kill-switch [PDF]
Stem Cell Research & TherapyBackground Pluripotent cell-derived islet replacement therapy offers promise for treating Type 1 diabetes (T1D), but concerns about uncontrolled cell proliferation and tumorigenicity present significant safety challenges.
Mohammad Izadifar +8 more
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Spleen extracellular matrix provides a supportive microenvironment for β-cell function [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Type 1 diabetes mellitus is a common autoimmune and multifactorial disorder. Researchers have been interested in making a favorable islet-like tissue model for the treatment of diabetes. The main objective of this study was to determine the
Layasadat Khorsandi +5 more
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Pancreatic α-Cell Dysfunction in Type 2 Diabetes: Old Kids on the Block [PDF]
Diabetes & Metabolism Journal, 2015 Type 2 diabetes (T2D) has been known as 'bi-hormonal disorder' since decades ago, the role of glucagon from α-cell has languished whereas β-cell taking center stage.
Jun Sung Moon, Kyu Chang Won
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Bioactivity of Flavonoids on Insulin‐Secreting Cells [PDF]
Comprehensive Reviews in Food Science and Food Safety, 2008 ABSTRACT: Flavonoids are usually found in fruits and other plant organs and therefore widely consumed. They are antioxidants, anti‐inflammatory, anticarcinogenic, and protective against coronary disease and metabolic disorders.
Pinent, Montserrat +5 more
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iScience, 2023 Summary: Glucocorticoid use is associated with steroid-induced diabetes mellitus and impaired pancreatic β-cell insulin secretion. Here, the glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting EndoC ...
Alexandros Karagiannopoulos +5 more
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Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity [PDF]
Journal of Biological Chemistry, 2017 Julie Saba +2 more
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Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination. [PDF]
PLoS ONE, 2013 Obesity is a major risk factor for diabetes and is typically associated with hyperleptinemia and a state of leptin resistance. The impact of chronically elevated leptin levels on the function of insulin-secreting β-cells has not been elucidated.
Eva Tudurí +5 more
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