Results 21 to 30 of about 57,117 (262)

The Combined Expression of and with Either or Improves the Differentiation Efficiency of Mouse Embryonic Stem Cells into Insulin-Producing Cells

Cell Transplantation, 2013
The use of pancreatic β-cells differentiated from embryonic stem (ES) cells or induced pluripotent stem (iPS) cells is a promising strategy in cell therapy. Pancreatic β-cell development is regulated by the sequential expression of a molecular network of
Huiming Xu, Kam Sze Tsang, Juliana C. N. Chan, Ping Yuan, Rongrong Fan, Hideaki Kaneto, Gang Xu   +6 more
doaj   +1 more source

Generation of human islet cell type-specific identity genesets

Nature Communications, 2022
Generation of surrogate cells with stable functional identities is crucial for developing cell-based therapies. Efforts to produce insulin-secreting replacement cells to treat diabetes require reliable tools to assess islet cellular identity.
Léon van Gurp, Leon Fodoulian, Daniel Oropeza, Kenichiro Furuyama, Eva Bru-Tari, Anh Nguyet Vu, John S. Kaddis, Iván Rodríguez, Fabrizio Thorel, Pedro L. Herrera   +9 more
doaj   +1 more source

Characterization of prenylcysteine methyltransferase in insulin-secreting cells [PDF]

Biochemical Journal, 1996
Prenylcysteine carboxymethyltransferase, an enzyme involved in the post-translational modification of many signalling proteins, was characterized in insulin-secreting INS-1 cells and normal rat pancreatic islets. The activity of this enzyme was monitored by the methylation of an artificial substrate (a prenylated cysteine analogue) with S-adenosyl ...
G, Li, A, Kowluru, S A, Metz
openaire   +2 more sources

Human Insulin Secreted from Insulinogenic Xenograft Restores Normoglycemia in Type 1 Diabetic Mice without Immunosuppression

Cell Transplantation, 2012
In the present study, we examined the therapeutic potential of human amnion-derived insulin-secreting cells for type 1 diabetes. Human amniotic mesenchymal stem cells (hAMs) were isolated from amnion and cultivated to differentiate into insulin-secreting
J. Kim, S. Park, H. M. Kang, C. W. Ahn, H. C. Kwon, J. H. Song, Y. J. Lee, K. H. Lee, H. Yang, S. Y. Baek, S. H. Yoo, S. H. Kim, H. Kim   +12 more
doaj   +1 more source

Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss

BMC Genomics, 2021
Background Loss of pancreatic insulin-secreting β-cells due to metabolic or autoimmune damage leads to the development of diabetes. The discovery that α-cells can be efficiently reprogrammed into insulin-secreting cells in mice and humans has opened ...
Daniel Oropeza, Valentina Cigliola, Agustín Romero, Simona Chera, Santiago A. Rodríguez-Seguí, Pedro L. Herrera   +5 more
doaj   +1 more source

ROCK1 regulates insulin secretion from β-cells [PDF]

Molecular Metabolism, 2021
ABSTRACT Objective The endocrine pancreatic β-cells play a pivotal role in the maintenance of whole-body glucose homeostasis and its dysregulation is a consistent feature in all forms of diabetes. However, knowledge of intracellular regulators that modulate β-cell function remains incomplete.
Byung-Jun Sung, Sung-Bin Lim, Won-Mo Yang, Jae Hyeon Kim, Rohit N. Kulkarni, Young-Bum Kim, Moon-Kyu Lee   +6 more
openaire   +3 more sources

TRPC3 Regulates Islet Beta‐Cell Insulin Secretion

Advanced Science, 2023
AbstractInsulin release is tightly controlled by glucose‐stimulated calcium (GSCa) through hitherto equivocal pathways. This study investigates TRPC3, a non‐selective cation channel, as a critical regulator of insulin secretion and glucose control. TRPC3's involvement in glucose‐stimulated insulin secretion (GSIS) is studied in human and animal islets.
Gaëlle Rached, Youakim Saliba, Dina Maddah, Joelle Hajal, Viviane Smayra, Jules‐Joel Bakhos, Klaus Gröschner, Lutz Birnbaumer, Nassim Farès   +8 more
openaire   +4 more sources

Differentiation of Endogenous Bone Marrow-Derived Cells into Insulin-Producing Cells Using Four Soluble Factors [PDF]

Diabetes & Metabolism Journal
Four soluble factors—putrescine, glucosamine, nicotinamide, and signal transducer and activator of transcription 3 (STAT3) inhibitor BP-1-102—were shown to differentiate bone marrow mononucleated cells (BMNCs) into functional insulin-producing cells ...
Seung-Ah Lee, Subin Kim, Seog-Young Kim, Jong Yoen Park, Hye Seung Jung, Sung Soo Chung, Kyong Soo Park   +6 more
doaj   +1 more source

Islet formation during the neonatal development in mice. [PDF]

PLoS ONE, 2009
The islet of Langerhans is a unique micro-organ within the exocrine pancreas, which is composed of insulin-secreting beta-cells, glucagon-secreting alpha-cells, somatostatin-secreting delta-cells, pancreatic polypeptide-secreting PP cells and ghrelin ...
Kevin Miller, Abraham Kim, German Kilimnik, Junghyo Jo, Uchenna Moka, Vipul Periwal, Manami Hara   +6 more
doaj   +1 more source

Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling

Nature Communications, 2022
In vitro differentiation of pancreatic beta cells offers a potential therapeutic approach for diabetes. Here they show human pluripotent stem cell derived pancreatic progenitors differentiate into insulin-secreting cells by crosstalk of WNT5A and BMP ...
Jolanta Chmielowiec, Wojciech J. Szlachcic, Diane Yang, Marissa A. Scavuzzo, Katrina Wamble, Alejandro Sarrion-Perdigones, Omaima M. Sabek, Koen J. T. Venken, Malgorzata Borowiak   +8 more
doaj   +1 more source