Results 41 to 50 of about 95,683 (204)

A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes

Frontiers in Immunology, 2021
To circumvent the limitations of available preclinical models for the study of type 1 diabetes (T1D), we developed a new humanized model, the YES-RIP-hB7.1 mouse.
Sandrine Luce, Sandrine Luce, Sophie Guinoiseau, Sophie Guinoiseau, Alexis Gadault, Alexis Gadault, Franck Letourneur, Patrick Nitschke, Marc Bras, Michel Vidaud, Pierre Charneau, Etienne Larger, Etienne Larger, Maikel L. Colli, Decio L. Eizirik, Decio L. Eizirik, François Lemonnier, François Lemonnier, Christian Boitard, Christian Boitard, Christian Boitard   +20 more
doaj   +1 more source

A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of langerhans [PDF]

, 2008
Background: The extracellular calcium-sensing receptor (CaR) is expressed in many tissues that are not associated with Ca2+ homeostasis, including the endocrine cells in pancreatic islets of Langerhans.
Burns, Christopher, Jones, Peter, Kitsou-Mylona, Isidora, Persaud, Shanta, Squires, Paul   +4 more
core   +1 more source

Substantially increased sensitivity of the spot-ELISA for the detection of anti-insulin antibody-secreting cells using a capture antibody and enzyme-conjugated insulin [PDF]

, 1990
This paper describes an antibody capture spot-ELISA for the detection of anti-insulin antibody-secreting cells. The assay is based on the binding of secreted antibodies by immobilised isotype-specific capture antibodies and subsequent detection of ...
Benner, R. (Robbert), Claassen, H.J.H.M. (Eric), Vos, Q. (Quirijn)   +2 more
core   +1 more source

Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets [PDF]

, 2015
This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.AIMS/HYPOTHESIS: Ageing can lead to reduced insulin sensitivity and loss of pancreatic beta cell function ...
Allagnat, F, Guay, C, Harries, LW, Locke, JM, Marques, AC, Regazzi, R, Rutter, GA, Tugay, K   +7 more
core   +3 more sources

The Cell Physiology of Biphasic Insulin Secretion

Physiology, 2000
Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.
Rorsman, P, Eliasson, L, Renström, E, Gromada, J, Barg, S, Göpel, S   +5 more
openaire   +3 more sources

Mitochondrial Complexes I and II Are More Susceptible to Autophagy Deficiency in Mouse β-Cells [PDF]

Endocrinology and Metabolism, 2015
BackgroundDamaged mitochondria are removed by autophagy. Therefore, impairment of autophagy induces the accumulation of damaged mitochondria and mitochondrial dysfunction in most mammalian cells.
Min Joo Kim, Ok Kyong Choi, Kyung Sil Chae, Min Kyeong Kim, Jung Hee Kim, Masaaki Komatsu, Keiji Tanaka, Hakmo Lee, Sung Soo Chung, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Hye Seung Jung   +12 more
doaj   +1 more source

In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. [PDF]

, 2006
International audienceInsulin-secreting pancreatic beta cells are exceptionally rich in zinc. In these cells, zinc is required for zinc-insulin crystallization within secretory vesicles.
Chimienti, Fabrice, Devergnas, Séverine, Favier, Alain, Garcia-Cuenca, Rachel, Grunwald, Didier, Kerr-Conte, Julie, Pattou, François, Schuit, Frans,, Seve, Michel, van Lommel, Leentje, Vandewalle, Brigitte   +10 more
core   +3 more sources

2-Ketoisocaproate transport in insulin-secreting cells

Bioscience Reports, 1992
The transport of the nutrient secretagogue 2-ketoisocaproate (KIC) was studied in isolated rat pancreatic islets and in the HIT-T15 insulinoma cell line using an oil-filtration technique. In both islets and HIT-T15 cells, KIC uptake was a slow process, not reaching equilibrium within 10 min KIC transport was not dependent upon Na+ in the medium, was ...
L, Best, R, Trebilcock, S, Tomlinson
openaire   +2 more sources

Human islets contain four distinct subtypes of β cells

Nature Communications, 2016
Dysfunction or loss of insulin-secreting β cells in the pancreas is a hallmark of diabetes. Here, Dorrell et al.identify four subpopulations of β cells in humans, which differ in gene expression and insulin secretion kinetics, and the abundance of which ...
Craig Dorrell, Jonathan Schug, Pamela S. Canaday, Holger A. Russ, Branden D. Tarlow, Maria T. Grompe, Tamara Horton, Matthias Hebrok, Philip R. Streeter, Klaus H. Kaestner, Markus Grompe   +10 more
doaj   +1 more source

TRPM2 modulates insulin secretion in pancreatic β-cells [PDF]

Islets, 2011
Insulin secretion from pancreatic β-cells is the primary mechanism by which the body lowers blood glucose concentrations. Glucose is the principal stimulator of insulin secretion, and the primary pathway involved in glucose-stimulated insulin secretion is the ATP-sensitive K+ channel voltage-gated Ca2+ channel-mediated pathway.
Kunitoshi, Uchida, Makoto, Tominaga
openaire   +2 more sources