β-Cell Mitochondria and Insulin Secretion
Diabetes, 2002 The β-cell mitochondria are known to generate metabolic coupling factors, or messengers, that mediate plasma membrane depolarization and the increase in cytosolic Ca2+, the triggering event in glucose-stimulated insulin secretion. Accordingly, ATP closes nucleotide-sensitive K+ channels necessary for the opening of voltage-gated Ca2+ channels. ATP also
Claes B. Wollheim, Pierre Maechler
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Acromegaly: pathogenesis & treatment [PDF]
, 2019 Acromegaly is a multi-system disorder whose etiology is most often traced back to a growth hormone-secreting pituitary adenoma (PA). Growth hormone (GH) secretion promotes insulin-like growth factor 1 (IGF-1) release from peripheral tissues, leading to ...
Tilvawala, Megha
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Mesenchymal Stem Cell Therapy in Type 1 Diabetes Mellitus and Its Main Complications: From Experimental Findings to Clinical Practice [PDF]
, 2014 Type 1 diabetes mellitus (T1DM) is a complex multifactorial disorder which involves a loss of self-tolerance leading to the autoimmune destruction of pancreatic β−cells.
Arango Rodriguez, Martha +3 more
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Calbindin-D9k Ablation Disrupt Glucose/Pancreatic Insulin Homeostasis.
PLoS ONE, 2016 It has been proposed that cellular Ca2+ signals activate hormone secretion. In pancreatic β cells, which produce insulin, Ca2+ signals have been known to contribute to insulin secretion.
Changhwan Ahn +5 more
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Cell Journal, 2018 Objective: Type 1 diabetes is caused by destruction of beta cells of pancreas. Vildagliptin (VG), a dipeptidyl peptidase IV (DPP IV) inhibitor, is an anti-diabetic drug, which increases beta cell mass.
Samaneh Karimi +4 more
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Reversal of hyperglycemia by insulin-secreting rat bone marrow- and blastocyst-derived hypoblast stem cell-like cells. [PDF]
PLoS ONE, 2013 β-cell replacement may efficiently cure type 1 diabetic (T1D) patients whose insulin-secreting β-cells have been selectively destroyed by autoantigen-reactive T cells.
Anujith Kumar +15 more
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Characterization of prenylcysteine methyltransferase in insulin-secreting cells [PDF]
Biochemical Journal, 1996 Prenylcysteine carboxymethyltransferase, an enzyme involved in the post-translational modification of many signalling proteins, was characterized in insulin-secreting INS-1 cells and normal rat pancreatic islets. The activity of this enzyme was monitored by the methylation of an artificial substrate (a prenylated cysteine analogue) with S-adenosyl ...
G, Li, A, Kowluru, S A, Metz
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Differentiation of human embryonic stem cells into insulin- secreting cells
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2006 Introduction: Type I diabetes mellitus is caused by autoimmune destruction of the insulin-producing β-cells. A new potential method for curing the disease is transplantation of differentiated insulin- secreting cells from human embryonic stem cells ...
S Mollamohammadi +3 more
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Insulin secretion hot spots in pancreatic β cells as secreting adhesions
Frontiers in Cell and Developmental Biology, 2023 Pancreatic β cell secretion of insulin is crucial to the maintenance of glucose homeostasis and prevention of diseases related to glucose regulation, including diabetes.
Margret A. Fye, Irina Kaverina
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Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells [PDF]
, 2012 Peer reviewedPublisher ...
A Kubo +42 more
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