Results 71 to 80 of about 95,683 (204)
Cell Transplantation, 2020 Since the 1970s, rodent and human insulin-secreting pancreatic beta-cell lines have been developed and found useful for studying beta-cell biology. Surprisingly, although the dog has been widely used as a translational model for diabetes, no canine ...
P Czernichow, K Reynaud, P Ravassard
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Proteomic Analysis Reveals a Mitochondrial Remodeling of βTC3 Cells in Response to Nanotopography
Frontiers in Cell and Developmental Biology, 2020 Recently, using cluster-assembled zirconia substrates with tailored roughness produced by supersonic cluster beam deposition, we demonstrated that β cells can sense nanoscale features of the substrate and can translate these stimuli into a ...
Elisa Maffioli +15 more
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Reprogramming—Evolving Path to Functional Surrogate β-Cells
Cells, 2022 Numerous cell sources are being explored to replenish functional β-cell mass since the proof-of -concept for cell therapy of diabetes was laid down by transplantation of islets. Many of these cell sources have been shown to possess a degree of plasticity
Eric Kalo, Scott Read, Golo Ahlenstiel
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ATP mediates both activation and inhibition of K(ATP) channel activity via cAMP-dependent protein kinase in insulin-secreting cell lines. [PDF]
, 1989 The single-channel recording technique was employed to investigate the mechanism conferring ATP sensitivity to a metabolite-sensitive K channel in insulin-secreting cells.
Ciani, S, Eddlestone, GT, Ribalet, B
core
Dynamin Is Functionally Coupled to Insulin Granule Exocytosis [PDF]
, 2007 The insulin granule integral membrane protein marker phogrin-green fluorescent protein was co-localized with insulin in Min6B1 beta-cell secretory granules but did not undergo plasma membrane translocation following glucose stimulation.
Gaisano, HY +7 more
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Recent Advances in Obesity-induced Inflammation and Insulin Resistance.
Frontiers in Endocrinology, 2013 It has been demonstrated in rodents and humans that chronic inflammation characterized by macrophage infiltration occurs mainly in adipose tissue or liver during obesity, in which activation of immune cells is closely associated with insulin sensitivity.
Sanshiro eTateya +3 more
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Insulin-secreting β-Cell Dysfunction Induced by Human Lipoproteins [PDF]
Journal of Biological Chemistry, 2003 Diabetes is associated with significant changes in plasma concentrations of lipoproteins. We tested the hypothesis that lipoproteins modulate the function and survival of insulin-secreting cells. We first detected the presence of several receptors that participate in the binding and processing of plasma lipoproteins and confirmed the internalization of
Roehrich, Marc-Estienne Maurice +10 more
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Oleanolic acid enhances insulin secretion in pancreatic β‐cells [PDF]
FEBS Letters, 2008 We investigated the effect of oleanolic acid, a plant‐derived triterpenoid, on insulin secretion and content in pancreatic β‐cells and rat islets. Oleanolic acid significantly enhanced insulin secretion at basal and stimulatory glucose concentrations in INS‐1 832/13 cells and enhanced acute glucose‐stimulated insulin secretion in isolated rat islets ...
Teodoro, T. +5 more
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The spleen: a hub connecting nervous and immune systems in cardiovascular and metabolic diseases [PDF]
, 2017 Metabolic disorders have been identified as major health problems affecting a large portion of the world population. In addition, obesity and insulin resistance are principal risk factors for the development of cardiovascular diseases.
Carnevale, Daniela +3 more
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E-cadherin expression is associated with somatostatin analogue response in acromegaly [PDF]
, 2018 Acromegaly is a rare disease resulting from hypersecretion of growth hormone (GH) and insulin‐like growth factor 1 (IGF1) typically caused by pituitary adenomas, which is associated with increased mortality and morbidity. Somatostatin analogues (SSAs)
Cano, David A. +10 more
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