Results 81 to 90 of about 57,117 (262)
Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
Nature Communications, 2019 Defective CFTR protein, responsible for Cystic Fibrosis (CF), is highly expressed in pancreatic ductal epithelial cells (PDECs) but their impact on insulin secreting pancreatic islets is not fully understood.
Kyu Shik Mun +10 more
doaj +1 more source
Scaffolds for islets and stem cells differentiated into insulin-secreting cells
Frontiers in Bioscience, 2014 Embryonic/pluripotent stem cells offer the possibility of an unlimited source of cells to be differentiated into beta cells. This requires differentiating the stem cells into pancreatic progenitors by tissue culture, and then transplanting into recipients for the final stages of development into mature beta-cells.
Bernard E, Tuch +2 more
openaire +2 more sources
Advanced Materials Technologies, EarlyView.A label‐free impedimetric biosensor based on electroactive 3D porous graphene foam enables ultrasensitive and selective detection of CD81 protein and MCF‐7 cell‐derived extracellular vesicles in human serum. Detection limits of 0.048 fg/mL for CD81 and ∼24 EVs/mL are achieved, demonstrating a robust platform for selective, label‐free, and ...
Michael Robert Furness +11 more
wiley +1 more source
Indian Journal of Endocrinology and Metabolism, 2012 Background: Diabetics are incapable of producing insulin/have autoimmune mechanisms making it ineffective to control glucose secretion. We present a prospective study of glucose-sensitive insulin-secreting mesenchymal stem cells (IS-MSC) generated from ...
Shruti D Dave +2 more
doaj +1 more source
Potassium channels, imidazolines, and insulin-secreting cells.
Annals of the New York Academy of Sciences, 1995 Legacy description not ...
Mark J. Dunne +7 more
openaire +2 more sources
Advanced Science, EarlyView.Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen +20 more
wiley +1 more source
How does thymus infection by coxsackievirus contribute to the pathogenesis of type 1 diabetes?
Frontiers in Immunology, 2015 Through synthesis and presentation of neuroendocrine self-antigens by major histocompatibility complex (MHC) proteins, thymic epithelial cells (TECs) play a crucial role in programming central immune self-tolerance to neuroendocrine functions.
Hélène eMichaux +5 more
doaj +1 more source
Advanced Science, EarlyView.Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu +13 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2013 Upon functional loss of insulin producing islet β-cells, some patients with diabetes become dependent on life-long insulin supplementation therapy. Bioengineering surrogate insulin producing cells is an alternative replacement strategy. We have developed
Vikash Reebye +9 more
doaj +1 more source
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source