How does thymus infection by coxsackievirus contribute to the pathogenesis of type 1 diabetes?
Frontiers in Immunology, 2015 Through synthesis and presentation of neuroendocrine self-antigens by major histocompatibility complex (MHC) proteins, thymic epithelial cells (TECs) play a crucial role in programming central immune self-tolerance to neuroendocrine functions.
Hélène eMichaux +5 more
doaj +1 more source
Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments. [PDF]
, 1994 Polyreactive antibodies (Abs) constitute a major proportion of the early Ab repertoire and are an important component of the natural defense mechanisms against infections.
Casali, P, Ichiyoshi, Y
core +1 more source
Circulating miRNAs as predictive biomarkers of type 2 diabetes mellitus development in coronary heart disease patients fromt he CORDIOPREV study [PDF]
, 2018 Circulating microRNAs (miRNAs) have been proposed as type 2 diabetes biomarkers, and they may be a more sensitive way to predict development of the disease than the currently used tools.
Alcalá Díaz, Juan Francisco +13 more
core +4 more sources
Insulin Injections Promote the Growth of Aberrant Crypt Foci in the Colon of Rats [PDF]
, 1997 The main objective of the present study was to test the hypothesis that exogenous insulin would enhance colon carcinogenesis. Thirty-six female F344 rats, fed ad libitum a low fat rodent chow, received a single azoxymethane injection (20 mg/kg), and were
Corpet, Denis E. +3 more
core +1 more source
Voltage‐activated Ca2+ currents in insulin‐secreting cells
FEBS Letters, 1985 Membrane voltage and voltage‐clamped membrane currents have been investigated with the whole‐cell patch clamp method in the insulin‐secreting cell line RINm5F. The mean resting membrane potential of RINm5F cells was found to be −52 mV. Overshooting spike potentials could be evoked by membrane depolarisation in the absence of a secretagogue.
Findlay, Ian, Dunne, Mark J.
openaire +2 more sources
Proteoglycan profiling of human, rat and mouse insulin-secreting cells. [PDF]
Glycobiology, 2021 Nikpour M +5 more
europepmc +1 more source
Nature Communications, 2019 Glucagon-like peptide 1 (GLP-1) is released from intestinal L-cells following nutrient uptake and enhances insulin release as well as promotes satiety. Here, the authors demonstrate that GLP-1 secreting cells release ATP and that this stimulates nodose ...
Van B. Lu +10 more
doaj +1 more source
Inhibition of miR-146a-5p and miR-8114 in Insulin-Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa. [PDF]
Endocrinol Metab (Seoul), 2022 Su S +12 more
europepmc +1 more source
Using recombinase-mediated cassette exchange to engineer MIN6 insulin-secreting cells based on a newly identified safe harbor locus. [PDF]
J Diabetes Investig, 2021 Furukawa A +7 more
europepmc +1 more source
Hyperglycemia-Induced Dysregulated Fusion Intermediates in Insulin-Secreting Cells Visualized by Super-Resolution Microscopy. [PDF]
Front Cell Dev Biol, 2021 Yang G +5 more
europepmc +1 more source