Results 111 to 120 of about 131,691 (303)
Advanced Materials, EarlyView.Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou +5 more
wiley +1 more source
Scaffolds for islets and stem cells differentiated into insulin-secreting cells
Frontiers in Bioscience, 2014 Embryonic/pluripotent stem cells offer the possibility of an unlimited source of cells to be differentiated into beta cells. This requires differentiating the stem cells into pancreatic progenitors by tissue culture, and then transplanting into recipients for the final stages of development into mature beta-cells.
Bernard E, Tuch +2 more
openaire +2 more sources
Betacellulin and Activin A Coordinately
, 2014 Rat pancreatic AR42J cells possess exocrine and neuroendocrine properties. Activin A induces morphological changes and converts them into neuron-like cells. In activin-treated cells, mRNA for pancreatic polypeptide (PP) but not that for either insulin or
Convert Amylase-secreting Pancreatic +5 more
core
, 2020 Type 2 diabetes, characterized by dysfunction of pancreatic β-cells and insulin resistance in peripheral organs, accounts for more than 90% of all diabetes.
Mulder, Hindrik, +5 more
core +1 more source
Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
Nature Communications, 2019 Defective CFTR protein, responsible for Cystic Fibrosis (CF), is highly expressed in pancreatic ductal epithelial cells (PDECs) but their impact on insulin secreting pancreatic islets is not fully understood.
Kyu Shik Mun +10 more
doaj +1 more source
Indian Journal of Endocrinology and Metabolism, 2012 Background: Diabetics are incapable of producing insulin/have autoimmune mechanisms making it ineffective to control glucose secretion. We present a prospective study of glucose-sensitive insulin-secreting mesenchymal stem cells (IS-MSC) generated from ...
Shruti D Dave +2 more
doaj +1 more source
Development of Nanoflare Nanosensors for Monitoring Cellular Insulin mRNA in Beta Cells and Islets
Advanced Materials Technologies, EarlyView.This study presents the design and application of In2‐NF probes for detecting insulin mRNA in beta cells and islets. Using spherical nucleic acid‐coated gold nanoparticles, the probes offer strong fluorescent signals upon hybridization. Their performance is validated across 2D and 3D cultures and rat islets, demonstrating sensitive, real‐time mRNA ...
Yana Hu +7 more
wiley +1 more source
How does thymus infection by coxsackievirus contribute to the pathogenesis of type 1 diabetes?
Frontiers in Immunology, 2015 Through synthesis and presentation of neuroendocrine self-antigens by major histocompatibility complex (MHC) proteins, thymic epithelial cells (TECs) play a crucial role in programming central immune self-tolerance to neuroendocrine functions.
Hélène eMichaux +5 more
doaj +1 more source
Topography‐Regulated Screening Platform for Myoblast Contact Guidance
Advanced Materials Technologies, EarlyView.This study develops a topography‐regulated screening platform (12 gradients in 96‐topography‐well plate) enabling analysis of skeletal muscle morphogenesis. The topography‐induced cell morphology changed, cell polarization, and myotube differentiation, establishing an evaluative framework for generating pathologically relevant myotube phenotypes to ...
Tianqi Feng +6 more
wiley +1 more source
Signaling in Insulin-Secreting MIN6 Pseudoislets and Monolayer Cells
, 2016 Cell–cell interactions are of fundamental importance for cellular function. In islets of Langerhans, which control blood glucose levels by secreting insulin in response to the blood glucose concentration, the secretory response of intact islets is higher
Konstantin A. Artemenko (1874953) +7 more
core +1 more source