Results 31 to 40 of about 131,508 (302)
Generation of human islet cell type-specific identity genesets
Nature Communications, 2022 Generation of surrogate cells with stable functional identities is crucial for developing cell-based therapies. Efforts to produce insulin-secreting replacement cells to treat diabetes require reliable tools to assess islet cellular identity.
Léon van Gurp +9 more
doaj +1 more source
Characterization of prenylcysteine methyltransferase in insulin-secreting cells [PDF]
Biochemical Journal, 1996 Prenylcysteine carboxymethyltransferase, an enzyme involved in the post-translational modification of many signalling proteins, was characterized in insulin-secreting INS-1 cells and normal rat pancreatic islets. The activity of this enzyme was monitored by the methylation of an artificial substrate (a prenylated cysteine analogue) with S-adenosyl ...
G, Li, A, Kowluru, S A, Metz
openaire +2 more sources
Mechanisms of exocytosis in insulin-secreting B-cells and glucagon-secreting A-cells [PDF]
, 2003 In pancreatic B- and A-cells, metabolic stimuli regulate biochemical and electrical processes that culminate in Ca2+-influx and release of insulin or glucagon, respectively.
Barg, Sebastian
core +2 more sources
Cell Transplantation, 2013 The use of pancreatic β-cells differentiated from embryonic stem (ES) cells or induced pluripotent stem (iPS) cells is a promising strategy in cell therapy. Pancreatic β-cell development is regulated by the sequential expression of a molecular network of
Huiming Xu +6 more
doaj +1 more source
Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss
BMC Genomics, 2021 Background Loss of pancreatic insulin-secreting β-cells due to metabolic or autoimmune damage leads to the development of diabetes. The discovery that α-cells can be efficiently reprogrammed into insulin-secreting cells in mice and humans has opened ...
Daniel Oropeza +5 more
doaj +1 more source
TRPC3 Regulates Islet Beta‐Cell Insulin Secretion
Advanced Science, 2023 AbstractInsulin release is tightly controlled by glucose‐stimulated calcium (GSCa) through hitherto equivocal pathways. This study investigates TRPC3, a non‐selective cation channel, as a critical regulator of insulin secretion and glucose control. TRPC3's involvement in glucose‐stimulated insulin secretion (GSIS) is studied in human and animal islets.
Gaëlle Rached +8 more
openaire +4 more sources
Cell Transplantation, 2012 In the present study, we examined the therapeutic potential of human amnion-derived insulin-secreting cells for type 1 diabetes. Human amniotic mesenchymal stem cells (hAMs) were isolated from amnion and cultivated to differentiate into insulin-secreting
J. Kim +12 more
doaj +1 more source
Engineered commensal bacteria reprogram intestinal cells into glucose-responsive insulin-secreting cells for the treatment of diabetes. [PDF]
Diabetes, 2015 Duan FF, Liu JH, March JC.
europepmc +2 more sources
Islet formation during the neonatal development in mice. [PDF]
PLoS ONE, 2009 The islet of Langerhans is a unique micro-organ within the exocrine pancreas, which is composed of insulin-secreting beta-cells, glucagon-secreting alpha-cells, somatostatin-secreting delta-cells, pancreatic polypeptide-secreting PP cells and ghrelin ...
Kevin Miller +6 more
doaj +1 more source
Disruption of Glucose Sensing and Insulin Secretion by Ribozyme Kir6.2-Gene Targeting in Insulin-Secreting Cells [PDF]
Endocrinology, 2004 The ATP-sensitive K+ (KATP) channel, composed of Kir6.2 and sulfonylurea receptor (SUR1), in pancreatic beta-cells is believed to serve as a metabolic sensor regulating insulin secretion according to glucose levels. Thus, genetic disruption of Kir6.2 expression may impair KATP channel function in glucose sensing and insulin secretion.
Li, Li +3 more
openaire +2 more sources