Results 11 to 20 of about 131,508 (302)
Glucose represses connexin36 in insulin-secreting cells. [PDF]
Journal of Cell Science, 2005 The gap-junction protein connexin36 (Cx36) contributes to control the functions of insulin-producing cells. In this study, we investigated whether the expression of Cx36 is regulated by glucose in insulin-producing cells.
Haefliger, J.A. +4 more
core +6 more sources
Insulin-Secreting Cell Lines: Potential for Research and Therapy
, 2014 The pancreas anatomy in all mammals, in which islets of Langerhans are scattered throughout the parenchyma and comprise only 1-2% of the pancreas mass, makes it technically challenging to retrieve large numbers of pure islets for experimental purposes ...
Persaud, Shanta J.; id_orcid +8 more
core +2 more sources
Signaling in Insulin-Secreting MIN6 Pseudoislets and Monolayer Cells.
Journal of Proteome Research, 2013 peer reviewedCell-cell interactions are of fundamental importance for cellular function. In islets of Langerhans, which control blood glucose levels by secreting insulin in response to the blood glucose concentration, the secretory response of intact ...
Satagopam, Venkata P. +14 more
core +7 more sources
Cytotoxic action of methylglyoxal on insulin-secreting cells
Biochemical pharmacology, 2001 Methylglyoxal is a spontaneous product of glucose metabolism which is known to have cytotoxic actions and to be present in raised concentrations in hyperglycaemia. It could therefore play an important role in glucose toxicity.
Elizabeth A. Sheader +5 more
core +3 more sources
Pancreatic α-Cell Dysfunction in Type 2 Diabetes: Old Kids on the Block [PDF]
Diabetes & Metabolism Journal, 2015 Type 2 diabetes (T2D) has been known as 'bi-hormonal disorder' since decades ago, the role of glucagon from α-cell has languished whereas β-cell taking center stage.
Jun Sung Moon, Kyu Chang Won
doaj +1 more source
iScience, 2023 Summary: Glucocorticoid use is associated with steroid-induced diabetes mellitus and impaired pancreatic β-cell insulin secretion. Here, the glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting EndoC ...
Alexandros Karagiannopoulos +5 more
doaj +1 more source
Bioactivity of Flavonoids on Insulin‐Secreting Cells [PDF]
Comprehensive Reviews in Food Science and Food Safety, 2008 ABSTRACT: Flavonoids are usually found in fruits and other plant organs and therefore widely consumed. They are antioxidants, anti‐inflammatory, anticarcinogenic, and protective against coronary disease and metabolic disorders.
Pinent, Montserrat +5 more
openaire +3 more sources
Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination. [PDF]
PLoS ONE, 2013 Obesity is a major risk factor for diabetes and is typically associated with hyperleptinemia and a state of leptin resistance. The impact of chronically elevated leptin levels on the function of insulin-secreting β-cells has not been elucidated.
Eva Tudurí +5 more
doaj +1 more source
Vectorial insulin secretion by pancreatic β‐cells [PDF]
FEBS Letters, 1990 Morphological studies of pancreatic β‐cells have suggested the presence of discrete sensory and secretory domains. In the present study we now provide functional evidence by demonstrating polarity of insulin release by HIT‐T15 cells. A significant diffusion barrier across a twin chamber culture system was verified in the presence of confluent HIT‐T15 ...
Cortizo, Ana María +2 more
openaire +4 more sources
Insulin receptor signaling and glucagon-like peptide 1 effects on pancreatic beta cells. [PDF]
PLoS ONE, 2017 Glucagon-like peptide-1 (GLP-1) is a potent gluco-incretin hormone, which plays a central role on pancreatic beta cell proliferation, survival and insulin secreting activity and whose analogs are used for treating hyperglycemia in type 2 diabetes ...
Nunzia Caporarello +3 more
doaj +1 more source