Results 11 to 20 of about 57,117 (262)
Vectorial insulin secretion by pancreatic β‐cells [PDF]
FEBS Letters, 1990 Morphological studies of pancreatic β‐cells have suggested the presence of discrete sensory and secretory domains. In the present study we now provide functional evidence by demonstrating polarity of insulin release by HIT‐T15 cells. A significant diffusion barrier across a twin chamber culture system was verified in the presence of confluent HIT‐T15 ...
Cortizo, Ana María +2 more
openaire +4 more sources
Insulin receptor signaling and glucagon-like peptide 1 effects on pancreatic beta cells. [PDF]
PLoS ONE, 2017 Glucagon-like peptide-1 (GLP-1) is a potent gluco-incretin hormone, which plays a central role on pancreatic beta cell proliferation, survival and insulin secreting activity and whose analogs are used for treating hyperglycemia in type 2 diabetes ...
Nunzia Caporarello +3 more
doaj +1 more source
Rediscovering Primary Cilia in Pancreatic Islets [PDF]
Diabetes & Metabolism Journal, 2023 Primary cilia are microtubule-based sensory and signaling organelles on the surfaces of most eukaryotic cells. Despite their early description by microscopy studies, islet cilia had not been examined in the functional context until recent decades.
Eun Young Lee, Jing W. Hughes
doaj +1 more source
Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1. [PDF]
PLoS ONE, 2011 BACKGROUND:High fat diet-induced hyperglycemia and palmitate-stimulated apoptosis was prevented by specific inhibition of protein kinase C delta (PKCδ) in β-cells.
Felicia Ranta +11 more
doaj +1 more source
Overcoming the Limitations of Stem Cell-Derived Beta Cells
Biomolecules, 2022 Great advances in type 1 diabetes (T1D) and type 2 diabetes (T2D) treatment have been made to this day. However, modern diabetes therapy based on insulin injections and cadaveric islets transplantation has many disadvantages.
Mariana V. Karimova +2 more
doaj +1 more source
β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma”
Frontiers in Genetics, 2017 Type 1 diabetes is an auto-immune disease resulting in the loss of pancreatic β-cells and, consequently, in chronic hyperglycemia. Insulin supplementation allows diabetic patients to control their glycaemia quite efficiently, but treated patients still ...
Andhira Vieira +6 more
doaj +1 more source
The Cell Physiology of Biphasic Insulin Secretion
Physiology, 2000 Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.
Rorsman, P +5 more
openaire +3 more sources
Glucose represses connexin36 in insulin-secreting cells [PDF]
Journal of Cell Science, 2005 The gap-junction protein connexin36 (Cx36) contributes to control the functions of insulin-producing cells. In this study, we investigated whether the expression of Cx36 is regulated by glucose in insulin-producing cells. Glucose caused a significant reduction of Cx36 in insulin-secreting cell lines and freshly isolated pancreatic rat islets.
ALLAGNAT F +4 more
openaire +5 more sources
Size-controlled insulin-secreting cell clusters [PDF]
Acta Biomaterialia, 2012 The search for an effective cure for type I diabetes from the transplantation of encapsulated pancreatic β-cell clusters has so far produced sub-optimal clinical outcomes. Previous efforts have not controlled the size of transplanted clusters, a parameter implicated in affecting long-term viability and the secretion of therapeutically sufficient ...
Adam D, Mendelsohn +3 more
openaire +2 more sources
PLoS ONE, 2015 Type 1 diabetes (T1D) is caused by autoimmune disease that leads to the destruction of pancreatic β-cells. Transplantation of cadaveric pancreatic organs or pancreatic islets can restore normal physiology.
Sudhanshu P Raikwar +5 more
doaj +1 more source