Autophagy Involves in Differentiation of Insulin-Secreting Cells from Adipose Derived Stem Cells [PDF]
Cell Journal, 2021 Objective: Destruction of pancreatic beta-cells induces an insulin deficiency and causes type 1 diabetes. The role of autophagy in inducing insulin-secreting cells (ISCs) from adipose-derived mesenchymal stem cells (AMSCs) was investigated in the current
Mahmoud Hashemitabar +3 more
doaj +2 more sources
Generation of insulin-secreting cells from mouse gallbladder stem cells by small molecules in vitro [PDF]
Stem Cell Research & Therapy, 2019 Background Stem cell-derived pancreatic β-like cells hold great promise for treating diabetes. Gallbladder belongs to the extrahepatic bile duct system and possesses stem-like cells.
Fei Chen +9 more
doaj +2 more sources
The emerging field of pancreatic tissue engineering: A systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells [PDF]
Journal of Tissue Engineering, 2019 A bioartificial endocrine pancreas is proposed as a future alternative to current treatment options. Patients with insulin-secretion deficiency might benefit.
Gabriel Alexander Salg +8 more
doaj +2 more sources
Microfluidic chip systems for characterizing glucose-responsive insulin-secreting cells equipped with FailSafe kill-switch [PDF]
Stem Cell Research & TherapyBackground Pluripotent cell-derived islet replacement therapy offers promise for treating Type 1 diabetes (T1D), but concerns about uncontrolled cell proliferation and tumorigenicity present significant safety challenges.
Mohammad Izadifar +8 more
doaj +2 more sources
Replication confers β cell immaturity [PDF]
Nature Communications, 2018 Adult beta cells, which are highly specialised insulin-secreting cells, rarely replicate. Puri et al. demonstrate that beta cell proliferative capacity is inversely correlated with their functionality and differentiation state, by inducing proliferation ...
Sapna Puri +9 more
doaj +3 more sources
Generation of insulin‐secreting cells from human embryonic stem cells [PDF]
Development, Growth & Differentiation, 2006 A growth factor‐mediated selection method was used to obtained insulin‐secreting cells from human embryonic stem cells (hESC; Royan H1). Our resultant cells were positive for dithizone, a zinc‐chelating agent known to selectively stain pancreatic β cells and immunoreactive for antibodies against insulin, glucagon, and C‐peptide.
Hossein, Baharvand +3 more
openaire +4 more sources
ROCK1 regulates insulin secretion from β-cells [PDF]
Molecular Metabolism, 2021 ABSTRACTObjectiveThe endocrine pancreatic β-cells play a pivotal role in the maintenance of whole-body glucose homeostasis and its dysregulation is a consistent feature in all forms of diabetes. However, knowledge of intracellular regulators that modulate β-cell function remains incomplete.
Byung-Jun Sung +6 more
openaire +3 more sources
Spleen extracellular matrix provides a supportive microenvironment for β-cell function [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Type 1 diabetes mellitus is a common autoimmune and multifactorial disorder. Researchers have been interested in making a favorable islet-like tissue model for the treatment of diabetes. The main objective of this study was to determine the
Layasadat Khorsandi +5 more
doaj +1 more source
Design Principles of Pancreatic Islets: Glucose-dependent Coordination of Hormone Pulses [PDF]
, 2015 Pancreatic islets are functional units involved in glucose homeostasis. The multicellular system comprises three main cell types; $\beta$ and $\alpha$ cells reciprocally decrease and increase blood glucose by producing insulin and glucagon pulses, while ...
Hara, Manami +2 more
core +16 more sources
Pancreatic α-Cell Dysfunction in Type 2 Diabetes: Old Kids on the Block [PDF]
Diabetes & Metabolism Journal, 2015 Type 2 diabetes (T2D) has been known as 'bi-hormonal disorder' since decades ago, the role of glucagon from α-cell has languished whereas β-cell taking center stage.
Jun Sung Moon, Kyu Chang Won
doaj +1 more source