Results 31 to 40 of about 1,036,062 (294)

Accelerated Lipid Absorption in Mice Overexpressing Intestinal SR-BI [PDF]

Journal of Biological Chemistry, 2006
Dietary cholesterol absorption contributes to a large part of the circulating cholesterol. However, the mechanism of sterol intestinal uptake is not clearly elucidated. Scavenger receptor class B type I (SR-BI), major component in the control of cholesterol homeostasis, is expressed in the intestine, but its role in this organ remains unclear.
Bietrix, Florence, Yan, Daoguang, Nauze, Michel, Rolland, Corinne, Bertrand-Michel, Justine, Coméra, Christine, Schaak, Stephane, Barbaras, Ronald, Groen, Albert K., Perret, Bertrand, Tercé, François, Collet, Xavier   +11 more
openaire   +3 more sources

Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra- and extra-cellular domains. [PDF]

PLoS Pathogens, 2009
HCV entry into cells is a multi-step and slow process. It is believed that the initial capture of HCV particles by glycosaminoglycans and/or lipoprotein receptors is followed by coordinated interactions with the scavenger receptor class B type I (SR-BI),
Marlène Dreux, Viet Loan Dao Thi, Judith Fresquet, Maryse Guérin, Zélie Julia, Géraldine Verney, David Durantel, Fabien Zoulim, Dimitri Lavillette, François-Loïc Cosset, Birke Bartosch   +10 more
doaj   +1 more source

Endothelial HMGB1 Is a Critical Regulator of LDL Transcytosis via an SREBP2–SR-BI Axis

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objective: LDL (low-density lipoprotein) transcytosis across the endothelium is performed by the SR-BI (scavenger receptor class B type 1) receptor and contributes to atherosclerosis.
S. Ghaffari, Erika Jang, Farnoosh Naderinabi, R. Sanwal, Negar Khosraviani, Changsen Wang, B. Steinberg, N. Goldenberg, Jiro Ikeda, Warren L. Lee   +9 more
semanticscholar   +1 more source

SR-BI as a target of natural products and its significance in cancer.

Seminars in Cancer Biology, 2020
Scavenger receptor class B type I (SR-BI) protein is an integral membrane glycoprotein. SR-BI is emerging as a multifunctional protein, which regulates autophagy, efferocytosis, cell survival and inflammation. It is well known that SR-BI plays a critical
Dongdong Wang, Jiansheng Huang, Ting Gui, Yaxin Yang, Ting-ting Feng, N. Tzvetkov, Tao Xu, Z. Gai, Ying Zhou, Jingjie Zhang, A. Atanasov   +10 more
semanticscholar   +1 more source

SR-BI Selective Lipid Uptake [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2009
Objective— The purpose of this study was to investigate the interaction of SAA and SR-BI in remodeling of acute phase HDL (AP HDL). Methods and Results— We used SAA and SR-BI adenoviral vector expression models to study the ...
Maria C, de Beer, Nancy R, Webb, Nathan L, Whitaker, Joanne M, Wroblewski, Anisa, Jahangiri, Deneys R, van der Westhuyzen, Frederick C, de Beer   +6 more
openaire   +2 more sources

Scavenger receptor SR-BI in macrophage lipid metabolism [PDF]

Atherosclerosis, 2011
To investigate the mechanisms by which macrophage scavenger receptor BI (SR-BI) regulates macrophage cholesterol homeostasis and protects against atherosclerosis.The expression and function of SR-BI was investigated in cultured mouse bone marrow-derived macrophages (BMM).
Ailing, Ji, Jason M, Meyer, Lei, Cai, Akinwunmi, Akinmusire, Maria C, de Beer, Nancy R, Webb, Deneys R, van der Westhuyzen   +6 more
openaire   +2 more sources

Hepatoma cell density promotes claudin-1 and scavenger receptor BI expression and hepatitis C virus internalization. [PDF]

, 2009
Hepatitis C virus (HCV) entry occurs via a pH- and clathrin-dependent endocytic pathway and requires a number of cellular factors, including CD81, the tight-junction proteins claudin 1 (CLDN1) and occludin, and scavenger receptor class B member I (SR-BI).
Balfe, Peter, Grove, Joe, Hu, Ke, McKeating, Jane A, Mee, Christopher J, Schwarz, Anne K   +5 more
core   +2 more sources

SR-BI [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2003
Monocyte-derived macrophages are among the first cells to accumulate in atherosclerotic lesions. Primarily, they appear to scavenge lipids and lipoproteins from fatty streaks, but their long-term presence and accumulation of cholesterol and cholesteryl esters is the hallmark of atherosclerosis. Atherogenesis begins by a perturbation in the endothelium.
openaire   +2 more sources

Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport [PDF]

, 2014
A potent class of indolinyl-thiazole based inhibitors of cellular lipid uptake mediated by scavenger receptor, class B, type I (SR-BI) was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule ...
Bennion, Melissa, Dandapani, Sivaraman, Dockendorff, Chris, Faloon, Patrick W., Krieger, Monty, Lam, Garrett, Lewis, Timothy A., Munoz, Benito, Nag, Partha P., Negri, Joseph, Nieland, Thomas J.F., Palmer, Michelle A., Paterson, Conor, Penman, Marsha, Perez, José R., Pu, Jun, Schreiber, Stuart L., Youngsaye, Willmen, Yu, Miao   +18 more
core   +3 more sources

Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI

Journal of Lipid Research, 2006
Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) and facilitates the efflux of unesterified cholesterol. SR-BI expression in macrophages presumably plays a role in atherosclerosis.
May Brundert, Joerg Heeren, Mukaddes Bahar-Bayansar, Anne Ewert, Kathryn J. Moore, Franz Rinninger   +5 more
doaj   +1 more source