Results 31 to 40 of about 895,142 (270)

Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI

Journal of Lipid Research, 2007
Treatment of atherosclerotic disease often focuses on reducing plasma LDL-cholesterol or increasing plasma HDL-cholesterol. We examined in vitro the effects on HDL receptor [scavenger receptor class B type I (SR-BI)] activity of three classes of clinical
Thomas J.F. Nieland, Jared T. Shaw, Firoz A. Jaipuri, Zoltan Maliga, Jay L. Duffner, Angela N. Koehler, Monty Krieger   +6 more
doaj   +1 more source

SR-BI as target in atherosclerosis and cardiovascular disease - A comprehensive appraisal of the cellular functions of SR-BI in physiology and disease [PDF]

Atherosclerosis, 2017
High-density lipoprotein (HDL) is considered an anti-atherogenic lipoprotein species due to its role in reverse cholesterol transport. HDL delivers cholesterol esters to the liver through selective uptake by scavenger receptor class B type I (SR-BI). In line with the protective role for HDL in the context of cardiovascular disease, studies in mice and ...
openaire   +2 more sources

Influence of aspirin on SR-BI expression in human carotid plaques [PDF]

Atherosclerosis, 2009
We recently showed that aspirin promotes scavenger receptor class-B type I (SR-BI) protein expression in vitro in primary human macrophages and in vivo in resident peritoneal macrophages of mice.We compared SR-BI and CD68 expression in carotid atherosclerotic specimens from endarterectomized patients with (n=38) or without (n=19) low-dose aspirin ...
Andreas, Wehinger, Ivan, Tancevski, Ruediger, Seiler, Sandra M, Frotschnig, Stefan, Frantz, Julia, Huber, Philipp, Eller, Wilfried, Schgoer, Bernhard, Foeger, Josef R, Patsch, Andreas, Ritsch   +10 more
openaire   +2 more sources

Scavenger receptor class B type I localizes to a late endosomal compartment

Journal of Lipid Research, 2008
Scavenger receptor class B type I (SR-BI) has an established role in mediating the selective uptake of cholesterol from HDL in hepatocytes, steroidogenic cells, and other tissues.
Malika Ahras, Thet Naing, Ruth McPherson
doaj   +1 more source

Localization and regulation of SR-BI in membrane rafts of HepG2 cells [PDF]

Journal of Cell Science, 2004
The scavenger receptor class B, type I (SR-BI) mediates cholesteryl esters (CE) selective uptake from low density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. In a number of tissues expressing caveolin, SR-BI is localized in caveolae.
David, Rhainds, Philippe, Bourgeois, Geneviève, Bourret, Karine, Huard, Louise, Falstrault, Louise, Brissette   +5 more
openaire   +2 more sources

Hepatic lipase mediates an increase in selective uptake of HDL-associated cholesteryl esters by cells in culture independent from SR-BI

Journal of Lipid Research, 2003
Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) by the liver. Hepatic lipase (HL) promotes this lipid uptake independent from lipolysis.
May Brundert, Joerg Heeren, Heiner Greten, Franz Rinninger   +3 more
doaj   +1 more source

Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production

Journal of Lipid Research, 2009
Impaired scavenger receptor class B type I (SR-BI)-mediated uptake of HDL-cholesterol esters (HDL-CE) induces adrenal insufficiency in mice. Humans contain an alternative route of HDL-CE clearance, namely through the transfer by cholesteryl ester ...
Menno Hoekstra, Dan Ye, Reeni B. Hildebrand, Ying Zhao, Bart Lammers, Miranda Stitzinger, Johan Kuiper, Theo J.C. Van Berkel, Miranda Van Eck   +8 more
doaj   +1 more source

Regulation and splicing of scavenger receptor class B type I in human macrophages and atherosclerotic plaques

BMC Cardiovascular Disorders, 2005
Background The protective role of high-density lipoprotein (HDL) in the cardiovascular system is related to its role in the reverse transport of cholesterol from the arterial wall to the liver for subsequent excretion via the bile.
Fagerberg Björn, Thelle Dag S, Mattsson-Hulten Lillemor, Stemme Veronika, Ohlsson Bertil G, Hägg Daniel A, Snäckestrand Magnus SC, Englund Mikael CO, Svensson Per-Arne, Wiklund Olov, Carlsson Lena MS, Carlsson Björn   +11 more
doaj   +1 more source

Ontogeny, immunolocalisation, distribution and function of SR-BI in the human intestine [PDF]

Journal of Cell Science, 2004
Studies employing human fetal intestine have yielded remarkable information on the role of polarized enterocytes in fat absorption. In this report, we investigated the intestinal expression, spatiotemporal distributions, ontogeny and function of the scavenger receptor, Class B, Type I (SR-BI) that plays a crucial role in cholesterol homeostasis.
Emile, Levy, Daniel, Ménard, Isabelle, Suc, Edgard, Delvin, Valérie, Marcil, Louise, Brissette, Louise, Thibault, Moise, Bendayan   +7 more
openaire   +2 more sources

Quantification of apolipoprotein E receptors in human brain-derived cell lines by real-time polymerase chain reaction

, 2004
Apolipoprotein (apo) E4 is a risk factor for Alzheimer's disease (AD) and other neurodegenerative diseases, compared to wild-type apoE3. The mechanism(s) is unknown.
Owen, JS, Everett, D M, Murdock, P R, Everett, DM, Murdock, PR, Owen, J S, Dingwall, C, Thilakawardhana, S   +7 more
core   +1 more source