Results 1 to 10 of about 51,493 (310)

Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI

Journal of Lipid Research, 2007
Modified forms of LDL, including oxidized low density lipoprotein (OxLDL), contribute to macrophage lipid accumulation in the vessel wall. Despite the pathophysiological importance of uptake pathways for OxLDL, the molecular details of OxLDL endocytosis ...
Bing Sun, Boris B. Boyanovsky, Margery A. Connelly, Preetha Shridas, Deneys R. van der Westhuyzen, Nancy R. Webb   +5 more
doaj   +3 more sources

Loss of Function of Scavenger Receptor SCAV-5 Protects C. elegans Against Pathogenic Bacteria

Frontiers in Cellular and Infection Microbiology, 2021
Scavenger receptors play a critical role in innate immunity by acting as the pattern-recognition receptors. There are six class B scavenger receptors homologs in C. elegans.
Aixiao Luo, Huiru Jing, Lei Yuan, Yanzhe Wang, Hui Xiao, Qian Zheng   +5 more
doaj   +1 more source

Class A scavenger receptor 1 (MSR1) restricts hepatitis C virus replication by mediating toll-like receptor 3 recognition of viral RNAs produced in neighboring cells [PDF]

, 2013
Persistent infections with hepatitis C virus (HCV) may result in life-threatening liver disease, including cirrhosis and cancer, and impose an important burden on human health.
Dansako, Hiromichi, Hu, Fengyu, Kato, Nobuyuki, Lemon, Stanley M., McGivern, David R., Welsch, Christoph, Yamane, Daisuke   +6 more
core   +12 more sources

A gut feeling for drugs that have metabolic benefits

Nature Communications, 2023
Resveratrol (REV) is a natural polyphenol with anti-obesity effects. However, the mechanisms remain unclear due to its low bioavailability and the lack of defined membrane-bound or nuclear receptors.
Eryun Zhang, Alon Agua, Wendong Huang
doaj   +1 more source

HSL-knockout mouse testis exhibits class B scavenger receptor upregulation and disrupted lipid raft microdomains[S]

Journal of Lipid Research, 2012
There is a tight relationship between fertility and changes in cholesterol metabolism during spermatogenesis. In the testis, class B scavenger receptors (SR-B) SR-BI, SR-BII, and LIMP II mediate the selective uptake of cholesterol esters from HDL, which ...
María Emilia Casado, Lydia Huerta, Ana Isabel Ortiz, Mirian Pérez-Crespo, Alfonso Gutiérrez-Adán, Fredric B. Kraemer, Miguel Ángel Lasunción, Rebeca Busto, Antonia Martín-Hidalgo   +8 more
doaj   +1 more source

Hepatoma cell density promotes claudin-1 and scavenger receptor BI expression and hepatitis C virus internalization. [PDF]

, 2009
Hepatitis C virus (HCV) entry occurs via a pH- and clathrin-dependent endocytic pathway and requires a number of cellular factors, including CD81, the tight-junction proteins claudin 1 (CLDN1) and occludin, and scavenger receptor class B member I (SR-BI).
Balfe, Peter, Grove, Joe, Hu, Ke, McKeating, Jane A, Mee, Christopher J, Schwarz, Anne K   +5 more
core   +2 more sources

ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36

Journal of Lipid Research, 2004
The class B scavenger receptors SR-BI and CD36 exhibit a broad ligand binding specificity. SR-BI is well characterized as a HDL receptor that mediates selective cholesteryl ester uptake from HDL.
Maria C. de Beer, Lawrence W. Castellani, Lei Cai, Arnold J. Stromberg, Frederick C. de Beer, Deneys R. van der Westhuyzen   +5 more
doaj   +1 more source

Overflow phenomenon in serum lutein after supplementation: a systematic review supported with SNPs analyses [PDF]

International Journal of Ophthalmology, 2021
Lutein, a type of carotenoids, is found to delay the onset and progression of age-related macular degeneration (AMD). Several lutein supplementation studies showed that after an initial increase, lutein serum levels demonstrated a subsequent decrease ...
Abdulrahman M Alharbi, Mohammed A Kilani, Tos TJM Berendschot   +2 more
doaj   +1 more source

Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System

Frontiers in Immunology, 2020
The absence of MHC class II antigen presentation and multiple pathogen recognition receptors in the Atlantic cod has not impaired its immune response however how underlying mechanisms have adapted remains largely unknown.
Xingkun Jin, Xingkun Jin, Xingkun Jin, Bernat Morro, Ole K. Tørresen, Visila Moiche, Monica H. Solbakken, Kjetill S. Jakobsen, Sissel Jentoft, Simon MacKenzie   +9 more
doaj   +1 more source

The hepatoadrenal syndrome: A common yet unrecognized clinical condition [PDF]

, 2005
Objective: Adrenal failure is common in critically ill patients, particularly those with sepsis. As liver failure and sepsis are both associated with increased circulating levels of endotoxin and proinflammatory mediators and reduced levels of apoprotein-
Acton, Ali, Annane, Annane, Baranova, Beishuizen, Borkowski, Calco, Cicognani, Cooper, Darlington, Davies, de la Llera-Moya, Dimopoulou, Eisenberg, Ettinger, Gordon, Hamrahian, Harry, Hinshaw, Jaattela, Kilger, Liu, Liu, Liu, Liu, Loriaux, Marik, Marik, Marik, Marik, Marik, McDonald, Melby, Miyata, Molijn, Molijn, Mookerjee, Paul E. Marik, Rasaratnam, Rivers, Scammell, Singh, Sun, Thomas E. Starzl, Timothy Gayowski, van der Voort, van Leeuwen, Vishnyakova, Yaguchi, Yokoyama, Yokoyama   +51 more
core   +1 more source